DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG4629 and SIK2

DIOPT Version :9

Sequence 1:	NP_608564.3	Gene:	CG4629 / 33284	FlyBaseID:	FBgn0031299	Length:	570	Species:	Drosophila melanogaster
Sequence 2:	NP_056006.1	Gene:	SIK2 / 23235	HGNCID:	21680	Length:	926	Species:	Homo sapiens

Alignment Length:	378	Identity:	123/378 - (32%)
Similarity:	202/378 - (53%)	Gaps:	53/378 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    62 RIGLYRFCGDIGRGNFSKVKLAVHQLTRDKVAIKVVDLDRAGLDAKALRMLSSEIATLECVHHPN 126
            |:|.|...|.:|:|||:.|||..|::|:.:||||::  |::.|||..|..:..|:..::.:.||:
Human    16 RVGFYDIEGTLGKGNFAVVKLGRHRITKTEVAIKII--DKSQLDAVNLEKIYREVQIMKMLDHPH 78

  Fly   127 ILRLFEVVETLGRVYLVTEWIRGGELYNHITQGGPLREIHAAPLLKQLLLAVKHMHSLGYVHRDI 191
            |::|::|:||...:|||||:.:.||:::::...|.|.|..|.....|:|.||.:.|....||||:
Human    79 IIKLYQVMETKSMLYLVTEYAKNGEIFDYLANHGRLNESEARRKFWQILSAVDYCHGRKIVHRDL 143

  Fly   192 KAENVLLLSEDRLKLADFGFSTQLINGANQKLDTFCGSPPYAAPELFSDDHYIGAPVDVWALGIL 256
            ||||:||.:...:|:|||||.....:|  :.|.|:||||||||||:|....|.|..:|:|::|::
Human   144 KAENLLLDNNMNIKIADFGFGNFFKSG--ELLATWCGSPPYAAPEVFEGQQYEGPQLDIWSMGVV 206

  Fly   257 LYFMVVGNMPFRAPTIPGLKAAILKGDYLLPGQLSLPCIRLIQRILIHIPAQRPTIDDMLNSQFV 321
            ||.:|.|.:||..||:|.|:..:|:|.:.:|..:|..|..||:|:|:..|::|.||.
Human   207 LYVLVCGALPFDGPTLPILRQRVLEGRFRIPYFMSEDCEHLIRRMLVLDPSKRLTIA-------- 263

  Fly   322 TCPKLSADLMQWEINQH-----TKPVKRSIFWVRSKSH------------RLRKSASLRDRYAEV 369
                        :|.:|     ..||:|.:.:.:.:.:            ||..|..:..
Human   264 ------------QIKEHKWMLIEVPVQRPVLYPQEQENEPSIGEFNEQVLRLMHSLGIDQ----- 311

  Fly   370 VKKPAISMNTRQQDEMFVQNFLQPIEM-GHELLVPVSSQLKEPQSTEQAKRPT 421
             :|...|:..:..:......||....: .|....||..:|...|     :||:
Human   312 -QKTIESLQNKSYNHFAAIYFLLVERLKSHRSSFPVEQRLDGRQ-----RRPS 358

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4629	NP_608564.3	STKc_NIM1	63..321	CDD:270977	103/257 (40%)
CG4629	NP_608564.3	S_TKc	66..321	CDD:214567	102/254 (40%)
SIK2	NP_056006.1	STKc_SIK	19..271	CDD:270973	104/275 (38%)
		UBA_SIK2	297..341	CDD:270592	7/49 (14%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	644..666
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	742..776
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	801..896
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910