Protein Alignment CG4629 and Melk

DIOPT Version :10

• Sequence 1: NP_608564.3
• Gene: CG4629 / 33284
• FlyBaseID: FBgn0031299
• Length: 570
• Species: Drosophila melanogaster
• Sequence 2: NP_034920.2
• Gene: Melk / 17279
• MGIID: 106924
• Length: 643
• Species: Mus musculus
• Alignment Length: 646
• Identity: 166/646 - (25%)
• Similarity: 260/646 - (40%)
• Gaps: 182/646 - (28%)

  Fly    66 YRFCGDIGRGNFSKVKLAVHQLTRDKVAIKVVDLDRAGLDAKALRMLSSEIATLECVHHPNILRL 130
            |.....||.|.|:|||||.|.||.:.||||::|.:..|.|   |..:.:||..|:.:.|.:|.:|
Mouse    11 YELYETIGTGGFAKVKLACHVLTGEMVAIKIMDKNALGSD---LPRVKTEIDALKSLRHQHICQL 72

  Fly   131 FEVVETLGRVYLVTEWIRGGELYNHITQGGPLREIHAAPLLKQLLLAVKHMHSLGYVHRDIKAEN 195
            :.|:||..::::|.|:..||||:::|.....|.|.....:.:|:|.||.::||.||.|||:|.||
Mouse    73 YHVLETKNKIFMVLEYCPGGELFDYIISQDRLSEEETRVVFRQILSAVAYVHSQGYAHRDLKPEN 137

  Fly   196 VLLLSEDRLKLADFGFSTQLINGANQKLDTFCGSPPYAAPELFSDDHYIGAPVDVWALGILLYFM 260
            :|.....:|||.|||...:.....:..|.|.|||..||||||.....|:|:..|||::|||||.:
Mouse   138 LLFDENHKLKLIDFGLCAKPKGNKDYHLQTCCGSLAYAAPELIQGKSYLGSEADVWSMGILLYVL 202

  Fly   261 VVGNMPFRAPTIPGLKAAILKGDYLLPGQLSLPCIRLIQRILIHIPAQRPTIDDMLNSQFV---- 321
            :.|.:||....:..|...|::|.|.:|..||...|.|:|::|...|.:|.::.::||..:|
Mouse   203 MCGFLPFDDDNVMALYKKIMRGKYEVPKWLSPSSILLLQQMLQVDPKKRISMRNLLNHPWVMQDY 267

  Fly   322 TCPKLSADLMQW---------------EINQHTKPVKRSI-----FW----------------VR 350
            :||      ::|               |::.|.:..::::     .|                .|
Mouse   268 SCP------VEWQSKTPLTHLDEDCVTELSVHHRSSRQTMEDLISSWQYDHLTATYLLLLAKKAR 326

  Fly   351 SKSHRLR---------------KSASLRD-------------------------RYAEVVKKPAI 375
            .|..||:               |:.||.|                         :..:|.|..|.
Mouse   327 GKPARLQLLSFSCGTASTTPKSKNLSLEDMSTSDDNCVAGLIDYELCEDKLLAPKTPQVTKHLAE 391

  Fly   376 SMNTRQQD-----EMFVQNFLQPIEMGHELLVP----------VSSQLKEPQSTEQAKR-----P 420
            |.:...:.     ...|.|.|...|   .:..|          |.|:.|.|.|..|.||     |
Mouse   392 SNHAASKSPAPGVRRAVANKLMDKE---NVCTPKSSVKNEEQFVFSEPKIPVSKNQYKREIPASP 453

  Fly   421 TRRYMFCGSLKKKVTPMETEPEKQLAN--GGQSIGSAKINP----------WNVEVAEDCPLFK- 472
            ||   |....|.:...:...|.:...|  |..::.:..|:|          .|....||.|..|
Mouse   454 TR---FPTPAKARAQCLREAPVRTPGNSAGADTLTTGVISPERRCRSMDVDLNQAHMEDTPKKKG 515

  Fly   473 ------------------------------------NYDAETGSCV-----------MLPTNTED 490
                                                :|:..|...|           :||....|
Mouse   516 TNVFGSLERGLDKVLTALTRNKKKGSARDGPRKRKLHYNVTTTRLVNPDQLLSEIMAILPKKNVD 580

  Fly   491 LSQLG-ALEFEARQILAELGLTSEMLINARQSGPRSDIIGAYRIVVNRLQKQSWLARKHVE 550
            ..|.| .|:.:.:....::.:..|:.:...|   |.|::|..|   .||:..:|:.::.||
Mouse   581 FVQKGYTLKCQTQSDFGKVTMQFELEVCQLQ---RPDVVGIRR---QRLKGDAWVYKRLVE 635

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG4629	NP_608564.3	STKc_NIM1	63..321	CDD:270977	99/254 (39%)
Melk	NP_034920.2	STKc_MELK	7..263	CDD:270980	99/254 (39%)
		UBA_MELK	281..332	CDD:270526	5/50 (10%)
		UBA-like. /evidence=ECO:0000250	282..321		3/38 (8%)
		Autoinhibitory region. /evidence=ECO:0000250	326..643		60/322 (19%)
		MELK_C	547..641	CDD:213383	20/95 (21%)