DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG4629 and NIM1K

DIOPT Version :9

Sequence 1:	NP_608564.3	Gene:	CG4629 / 33284	FlyBaseID:	FBgn0031299	Length:	570	Species:	Drosophila melanogaster
Sequence 2:	NP_699192.1	Gene:	NIM1K / 167359	HGNCID:	28646	Length:	436	Species:	Homo sapiens

Alignment Length:	525	Identity:	179/525 - (34%)
Similarity:	256/525 - (48%)	Gaps:	154/525 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    34 PPPTPPYQRLTKALQCDPRCGHEVTIGRRIGLYRFCGDIGRGNFSKVKLAVHQLTRDKVAIKVVD 98
            |....|:::||:.:..|.:...|:|:|:|||.||..|:||.||||:|||.:|.||::|||||:
Human    42 PRQLTPFEKLTQDMSQDEKVVREITLGKRIGFYRIRGEIGSGNFSQVKLGIHSLTKEKVAIKI-- 104

  Fly    99 LDRAGLDAKALRMLSSEIATLECVHHPNILRLFEVVETLGRVYLVTEWIRGGELYNHITQGGPLR 163
            ||:..||.|..|:||.||:::|.:|||||:||:||||||.:::||.|:..||||:..|:..|.|.
Human   105 LDKTKLDQKTQRLLSREISSMEKLHHPNIIRLYEVVETLSKLHLVMEYAGGGELFGKISTEGKLS 169

  Fly   164 EIHAAPLLKQLLLAVKHMHSLGYVHRDIKAENVLLLSEDRLKLADFGFSTQLINGANQKLDTFCG 228
            |..:..:..|::.||||||....:|||:|||||...|...:|:.||||||  ::...:.|:||||
Human   170 EPESKLIFSQIVSAVKHMHENQIIHRDLKAENVFYTSNTCVKVGDFGFST--VSKKGEMLNTFCG 232

  Fly   229 SPPYAAPELFSDDHYIGAPVDVWALGILLYFMVVGNMPFRAPTIPGLKAAILKGDYLLPGQLSLP 293
            ||||||||||.|:||||..||:||||:||||||.|.|||||.|:..||.:||:|.|.:|..:|.|
Human   233 SPPYAAPELFRDEHYIGIYVDIWALGVLLYFMVTGTMPFRAETVAKLKKSILEGTYSVPPHVSEP 297

  Fly   294 CIRLIQRILIHIPAQRPTIDDMLNSQFVTCPKLSADLMQWEINQHTKPVKRSIFWVRSKSHRLRK 358
            |.|||:.:|..||.:|..||.::|.:                            |::.
Human   298 CHRLIRGVLQQIPTERYGIDCIMNDE----------------------------WMQG------- 327

  Fly   359 SASLRDRYAEVVKKPAISMNTRQQDEMFVQNFLQPIEMGHELLVPVSSQLKEPQSTEQAKRPTRR 423
                                                       ||..
Human   328 -------------------------------------------VPYP------------------ 331

  Fly   424 YMFCGSLKKKVTPMETEPEKQLANGGQSIGSAKINPWNVEVAEDCPLFKNYDAETGSCVMLPTNT 488
                       ||:|                    |:.::                     |.:.
Human   332 -----------TPLE--------------------PFQLD---------------------PKHL 344

  Fly   489 EDLSQLGALEFEARQILAELGLTSEMLINARQSGPRSDIIGAYRIVVNRLQKQSWLARKHVEMAL 553
            .:.|.|...|.|.:..|..||:|.|.:.|.:....||.|.|.|||:::|:|::.  |.:.|.:.:
Human   345 SETSTLKEEENEVKSTLEHLGITEEHIRNNQGRDARSSITGVYRIILHRVQRKK--ALESVPVMM 407

  Fly   554 HSEPK 558
            ..:||
Human   408 LPDPK 412

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4629	NP_608564.3	STKc_NIM1	63..321	CDD:270977	139/257 (54%)
CG4629	NP_608564.3	S_TKc	66..321	CDD:214567	137/254 (54%)
NIM1K	NP_699192.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	23..55		4/12 (33%)
		STKc_NIM1	71..325	CDD:270977	139/285 (49%)
		S_TKc	74..325	CDD:214567	137/282 (49%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165160147
Domainoid	1	1.000	272	1.000	Domainoid score	I1815
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	341	1.000	Inparanoid score	I2364
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D251041at33208
OrthoFinder	1	1.000	-	-		FOG0005598
OrthoInspector	1	1.000	-	-		oto89273
orthoMCL	1	0.900	-	-		OOG6_108315
Panther	1	1.100	-	-	LDO	PTHR24343
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3502
SonicParanoid	1	1.000	-	-		X4010
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	12	11.890