Protein Alignment CG4629 and SIK1

DIOPT Version :9

• Sequence 1: NP_608564.3
• Gene: CG4629 / 33284
• FlyBaseID: FBgn0031299
• Length: 570
• Species: Drosophila melanogaster
• Sequence 2: NP_775490.2
• Gene: SIK1 / 150094
• HGNCID: 11142
• Length: 783
• Species: Homo sapiens
• Alignment Length: 500
• Identity: 156/500 - (31%)
• Similarity: 243/500 - (48%)
• Gaps: 91/500 - (18%)

  Fly    62 RIGLYRFCGDIGRGNFSKVKLAVHQLTRDKVAIKVVDLDRAGLDAKALRMLSSEIATLECVHHPN 126
            |:|.|.....:|:|||:.||||.|::|:.:||||::|..|  ||:..|..:..|:..::.::||:
Human    23 RVGFYDIERTLGKGNFAVVKLARHRVTKTQVAIKIIDKTR--LDSSNLEKIYREVQLMKLLNHPH 85

  Fly   127 ILRLFEVVETLGRVYLVTEWIRGGELYNHITQGGPLREIHAAPLLKQLLLAVKHMHSLGYVHRDI 191
            |::|::|:||...:|:|||:.:.||:::::|..|.|.|..|.....|:|.||::.|....||||:
Human    86 IIKLYQVMETKDMLYIVTEFAKNGEMFDYLTSNGHLSENEARKKFWQILSAVEYCHDHHIVHRDL 150

  Fly   192 KAENVLLLSEDRLKLADFGFSTQLINGANQKLDTFCGSPPYAAPELFSDDHYIGAPVDVWALGIL 256
            |.||:||.....:|||||||.....:|  :.|.|:||||||||||:|....|.|..:|:|:||::
Human   151 KTENLLLDGNMDIKLADFGFGNFYKSG--EPLSTWCGSPPYAAPEVFEGKEYEGPQLDIWSLGVV 213

  Fly   257 LYFMVVGNMPFRAPTIPGLKAAILKGDYLLPGQLSLPCIRLIQRILIHIPAQRPTIDDMLNSQFV 321
            ||.:|.|::||..|.:|.|:..:|:|.:.:|..:|..|..||:|:|:..||:|.||.
Human   214 LYVLVCGSLPFDGPNLPTLRQRVLEGRFRIPFFMSQDCESLIRRMLVVDPARRITIA-------- 270

  Fly   322 TCPKLSADLMQWEINQHTKPVKRSIFWVRSK------------SHRLRKSASLRDRYAEVVKKPA 374
                        :|.||.        |:|::            :|....:....|..|..:
Human   271 ------------QIRQHR--------WMRAEPCLPGPACPAFSAHSYTSNLGDYDEQALGI---- 311

  Fly   375 ISMNTRQQDEMFVQNFLQPIEMGH--ELLVPVSSQLKEPQSTE-----QAKRPTRRYMFCGSLKK 432
              |.|...|.......||.....|  .:...:..:|||.::.:     .|::|..|......|:.
Human   312 --MQTLGVDRQRTVESLQNSSYNHFAAIYYLLLERLKEYRNAQCARPGPARQPRPRSSDLSGLEV 374

  Fly   433 KVTPMETEPEK------QLANGGQSIGSAKINPWNVEVAEDC--------PLFKNYDAETGSC-- 481
            ....:.|:|.:      |.....||:..|::         ||        |||...||   ||
Human   375 PQEGLSTDPFRPALLCPQPQTLVQSVLQAEM---------DCELQSSLQWPLFFPVDA---SCSG 427

  Fly   482 VMLPTNTEDLSQLG-ALEFEARQILAELGLTSEMLINARQSGPRS 525
            |..|......|.|. |:..||||   ..||..|.  :.::|.|.|
Human   428 VFRPRPVSPSSLLDTAISEEARQ---GPGLEEEQ--DTQESLPSS 467

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG4629	NP_608564.3	STKc_NIM1	63..321	CDD:270977	104/257 (40%)
		S_TKc	66..321	CDD:214567	103/254 (41%)
SIK1	NP_775490.2	STKc_SIK	26..278	CDD:270973	106/283 (37%)
		S_TKc	27..278	CDD:214567	106/282 (38%)
		UBA_SIK1	300..349	CDD:270591	11/54 (20%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	353..377		4/23 (17%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	449..477		7/23 (30%)
		RK-rich region, required for cAMP responsiveness and nuclear localization. /evidence=ECO:0000305|PubMed:29211348	583..612
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	619..643

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910