DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG4629 and Mark2

DIOPT Version :9

Sequence 1:	NP_608564.3	Gene:	CG4629 / 33284	FlyBaseID:	FBgn0031299	Length:	570	Species:	Drosophila melanogaster
Sequence 2:	XP_006526704.1	Gene:	Mark2 / 13728	MGIID:	99638	Length:	851	Species:	Mus musculus

Alignment Length:	415	Identity:	138/415 - (33%)
Similarity:	232/415 - (55%)	Gaps:	34/415 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly    63 IGLYRFCGDIGRGNFSKVKLAVHQLTRDKVAIKVVDLDRAGLDAKALRMLSSEIATLECVHHPNI 127
            ||.||....||:|||:|||||.|.||..:||:|::  |:..|::.:|:.|..|:..::.::||||
Mouse    60 IGNYRLLKTIGKGNFAKVKLARHILTGKEVAVKII--DKTQLNSSSLQKLFREVRIMKVLNHPNI 122

  Fly   128 LRLFEVVETLGRVYLVTEWIRGGELYNHITQGGPLREIHAAPLLKQLLLAVKHMHSLGYVHRDIK 192
            ::||||:||...:|||.|:..|||:::::...|.::|..|....:|::.||::.|....||||:|
Mouse   123 VKLFEVIETEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYCHQKFIVHRDLK 187

  Fly   193 AENVLLLSEDRLKLADFGFSTQLINGANQKLDTFCGSPPYAAPELFSDDHYIGAPVDVWALGILL 257
            |||:||.::..:|:||||||.:...|  .|||||||||||||||||....|.|..||||:||::|
Mouse   188 AENLLLDADMNIKIADFGFSNEFTFG--NKLDTFCGSPPYAAPELFQGKKYDGPEVDVWSLGVIL 250

  Fly   258 YFMVVGNMPFRAPTIPGLKAAILKGDYLLPGQLSLPCIRLIQRILIHIPAQRPTIDDMLNSQFVT 322
            |.:|.|::||....:..|:..:|:|.|.:|..:|..|..|:::.||..|::|.|::.::..:::.
Mouse   251 YTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKKFLILNPSKRGTLEQIMKDRWMN 315

  Fly   323 CPKLSADLMQW--EINQHTKPVKRSIFWVRSKSHRLRKSASLRDRYAEV-------------VKK 372
            ......:|..:  .:..:..|.:..:......:....:.:.:..||.||             ::.
Mouse   316 VGHEDDELKPYVEPLPDYKDPRRTELMVSMGYTREEIQDSLVGQRYNEVMATYLLLGYKSSELEG 380

  Fly   373 PAISMNTRQQDEMFVQNFLQPIEMGHELLVPVSSQLKEPQSTEQA--KRPTRRYMFCGSLKKKVT 435
            ..|::..|...::...:...|   .|::...||:..|:.:|::||  ..||     ..|..||..
Mouse   381 DTITLKPRPSADLTNSSAPSP---SHKVQRSVSANPKQRRSSDQAVPAIPT-----SNSYSKKTQ 437

  Fly   436 PMETE---PEKQLANGGQSIGSAKI 457
            ....|   ||::  .|.::..:||:
Mouse   438 SNNAENKRPEEE--TGRKASSTAKV 460

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4629	NP_608564.3	STKc_NIM1	63..321	CDD:270977	111/257 (43%)
CG4629	NP_608564.3	S_TKc	66..321	CDD:214567	109/254 (43%)
Mark2	XP_006526704.1	STKc_MARK	62..314	CDD:270974	109/255 (43%)
		UBA_MARK2	332..373	CDD:270589	5/40 (13%)
		MARK2_C	752..850	CDD:213386
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910