DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG4629 and mark2b

DIOPT Version :9

Sequence 1:	NP_608564.3	Gene:	CG4629 / 33284	FlyBaseID:	FBgn0031299	Length:	570	Species:	Drosophila melanogaster
Sequence 2:	XP_009301419.1	Gene:	mark2b / 100005996	ZFINID:	ZDB-GENE-080215-4	Length:	790	Species:	Danio rerio

Alignment Length:	439	Identity:	143/439 - (32%)
Similarity:	240/439 - (54%)	Gaps:	58/439 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    51 PRCGHEVTIGR---RIGLYRFCGDIGRGNFSKVKLAVHQLTRDKVAIKVVDLDRAGLDAKALRML 112
            |||.:.|....   .||.||....||:|||:|||||.|.||..:||:|::  |:..|::.:|:.:
Zfish    31 PRCRNAVATAEEYPHIGNYRLLKTIGKGNFAKVKLARHVLTSKEVAVKII--DKTQLNSSSLQKV 93

  Fly   113 SSEIATLECVHHPNILRLFEVVETLGRVYLVTEWIRGGELYNHITQGGPLREIHAAPLLKQLLLA 177
            ..|:..::.::||||::||||:||...:|||.|:..|||:::::...|.::|..|....:|::.|
Zfish    94 FREVRIMKLLNHPNIVKLFEVIETDKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSA 158

  Fly   178 VKHMHSLGYVHRDIKAENVLLLSEDRLKLADFGFSTQLINGANQKLDTFCGSPPYAAPELFSDDH 242
            |::.|....||||:||||:||.::..:|:||||||.:...|  .|||||||||||||||||....
Zfish   159 VQYCHQKCIVHRDLKAENLLLDADMNIKIADFGFSNEFTVG--NKLDTFCGSPPYAAPELFQGKK 221

  Fly   243 YIGAPVDVWALGILLYFMVVGNMPFRAPTIPGLKAAILKGDYLLPGQLSLPCIRLIQRILIHIPA 307
            |.|..||||:||::||.:|.|::||....:..|:..:|:|.|.:|..:|..|..|:::.||..|.
Zfish   222 YDGPEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKKFLILNPT 286

  Fly   308 QRPTID-DMLNSQFVTC-------------------PKLSADLMQWEINQHTKPVKRSIFWVRSK 352
            :|.::: .::..:::..                   |:.:..::|...:|  :.::.|:  |:.|
Zfish   287 KRGSLEQQIMKDRWMNVGYEDDDLKPYIEPQPDYKDPRRTDIMLQMGFSQ--EEIEDSL--VKQK 347

  Fly   353 SHRLRKSASLRD-RYAEVVKKPAISMNTRQQDEMFVQNFLQPIEMGHELLVPVSSQLKEPQSTEQ 416
            .:.:..:..|.| |.:|:.:...:|:.:|...::...|...|   .|::...|||
Zfish   348 YNEVMATYLLLDYRNSELDEGVNLSLKSRPGSDLTNSNAPSP---PHKVQRSVSS---------- 399

  Fly   417 AKRPTRRYMFCGSLKKKVTPMETEPEKQLANGGQSIG------SAKINP 459
            .::|.||....||..|:       |:.:..:|.:..|      |.|:.|
Zfish   400 TQKPARRSTDQGSYSKR-------PQGENKHGVEDSGRKGSSSSTKVPP 441

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4629	NP_608564.3	STKc_NIM1	63..321	CDD:270977	109/258 (42%)
CG4629	NP_608564.3	S_TKc	66..321	CDD:214567	107/255 (42%)
mark2b	XP_009301419.1	STKc_MARK	48..301	CDD:270974	107/256 (42%)
		S_TKc	49..301	CDD:214567	107/255 (42%)
		UBA_MARK2	319..360	CDD:270589	7/44 (16%)
		AMPKA_C_like	691..789	CDD:302605
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910