Protein Alignment Atg4a and ATG4

DIOPT Version :9

• Sequence 1: NP_608563.1
• Gene: Atg4a / 33283
• FlyBaseID: FBgn0031298
• Length: 411
• Species: Drosophila melanogaster
• Sequence 2: NP_014176.2
• Gene: ATG4 / 855498
• SGDID: S000005167
• Length: 494
• Species: Saccharomyces cerevisiae
• Alignment Length: 453
• Identity: 107/453 - (23%)
• Similarity: 177/453 - (39%)
• Gaps: 116/453 - (25%)

  Fly     7 DQLARIMESVFE-------AYLGPDSVLASAV--------------------GQAVGSGEPEDIP 44
            |.:.::...|||       |.:..|.::...|                    |:||..|....:
Yeast    11 DLVQKVSHGVFEGSSEEPAALMNHDYIVLGEVYPERDEESGAEQCEQDCRYRGEAVSDGFLSSL- 74

  Fly    45 RRNTDVWVLGKKYNAIQELELIRRDIQSRLWCTYRHGFSPLGEVQ-------------------- 89
                    .|::.::..:..|:  |:|||:..|||..|.|:....
Yeast    75 --------FGREISSYTKEFLL--DVQSRVNFTYRTRFVPIARAPDGPSPLSLNLLVRTNPISTI 129

  Fly    90 ---------LTTDKGWGCMLRCGQMVLAQALIDLHLGRDWFWTPDCRDATYLKIVNRFEDVRNSF 145
                     ..||.|||||:|.||.:|..||..||||||:....:.......|.||.|.|...:.
Yeast   130 EDYIANPDCFNTDIGWGCMIRTGQSLLGNALQILHLGRDFRVNGNESLERESKFVNWFNDTPEAP 194

  Fly   146 YSIHQIAQMG-ESQNKAVGEWLGPNTVAQILKKLV-RFDDWSSLAIHVAMDSTVVLDDVYASCRE 208
            :|:|.....| |..:|..|||.||...|:.::.|: .|.:..             :||...|...
Yeast   195 FSLHNFVSAGTELSDKRPGEWFGPAATARSIQSLIYGFPECG-------------IDDCIVSVSS 246

  Fly   209 GGSWK-------------PLLLIIPLRLGITDINPLYVPALKRCLELDSSCGMIGGRPNQALYFL 260
            |..::             .:|.::.::|||..:|..|..::...|....|.|:.||||:.:|||.
Yeast   247 GDIYENEVEKVFAENPNSRILFLLGVKLGINAVNESYRESICGILSSTQSVGIAGGRPSSSLYFF 311

  Fly   261 GYVDDEVLYLDPHTTQRTGAVAQKTAAAEQDYDETYHQKHAARLNFSAMDPSLAVCFLCKTSDSF 325
            ||..:|.|:.|||..|         .|.|..:.|:.|.....:|..|.||||:.:..|.|....:
Yeast   312 GYQGNEFLHFDPHIPQ---------PAVEDSFVESCHTSKFGKLQLSEMDPSMLIGILIKGEKDW 367

  Fly   326 ESLLTKLKEEVLSLCSPALFEISQTRAVDWDTT---EDIDWPTMPDIDWPAGTSDSDSFAIVE 385
            :       :..|.:...|:..:...|..|:|.:   :|::  ::.........|::::..::|
Yeast   368 Q-------QWKLEVAESAIINVLAKRMDDFDVSCSMDDVE--SVSSNSMKKDASNNENLGVLE 421

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Atg4a	NP_608563.1	Peptidase_C54	66..328	CDD:281417	86/305 (28%)
ATG4	NP_014176.2	Peptidase_C54	84..371	CDD:397471	87/317 (27%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157343917
Domainoid	1	1.000	121	1.000	Domainoid score	I1249
eggNOG	1	0.900	-	-		E1_KOG2674
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H70873
Inparanoid	1	1.050	122	1.000	Inparanoid score	I1300
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000466
OrthoInspector	1	1.000	-	-		otm46790
orthoMCL	1	0.900	-	-		OOG6_100501
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R109
SonicParanoid	1	1.000	-	-		X289
TreeFam	1	0.960	-	-
	13	12.680