Protein Alignment Atg4a and ATG4D

DIOPT Version :9

• Sequence 1: NP_608563.1
• Gene: Atg4a / 33283
• FlyBaseID: FBgn0031298
• Length: 411
• Species: Drosophila melanogaster
• Sequence 2: NP_116274.3
• Gene: ATG4D / 84971
• HGNCID: 20789
• Length: 474
• Species: Homo sapiens
• Alignment Length: 421
• Identity: 133/421 - (31%)
• Similarity: 200/421 - (47%)
• Gaps: 82/421 - (19%)

  Fly    21 LGPDSVLASAVGQ-AVGSGEPEDIPRRNTDV----------WVL---------------GKKYNA 59
            |||......|:|. ..|..||:::.:.....          ||:               |::|..
Human    39 LGPSGASGPALGSPGAGPSEPDEVDKFKAKFLTAWNNVKYGWVVKSRTSFSKISSIHLCGRRYRF 103

  Fly    60 IQE--LELIRRDIQSRLWCTYRHGFSPLGEVQLTTDKGWGCMLRCGQMVLAQALIDLHLGRDWFW 122
            ..|  ::..:||..||||.|||..|.||....||:|.|||||||.|||:|||.|:...|.|||.|
Human   104 EGEGDIQRFQRDFVSRLWLTYRRDFPPLPGGCLTSDCGWGCMLRSGQMMLAQGLLLHFLPRDWTW 168

  Fly   123 ----------------------------------TPDC-RDATYLKIVNRFEDVRNSFYSIHQIA 152
                                              .|:. ::..:.:||:.|.|...:.:.:|::.
Human   169 AEGMGLGPPELSGSASPSRYHGPARWMPPRWAQGAPELEQERRHRQIVSWFADHPRAPFGLHRLV 233

  Fly   153 QMGESQNKAVGEWLGPNTVAQILKKLVR-FDDWSSLAIHVAMDSTVVLDDV---YASCREGGSWK 213
            ::|:|..|..|:|.||:.||.||:|.|. ..|.:.|.::|:.|.||...||   .|.......||
Human   234 ELGQSSGKKAGDWYGPSLVAHILRKAVESCSDVTRLVVYVSQDCTVYKADVARLVARPDPTAEWK 298

  Fly   214 PLLLIIPLRLGITDINPLYVPALKRCLELDSSCGMIGGRPNQALYFLGYVDDEVLYLDPHTTQRT 278
            .:::::|:|||...:||:|||.:|..|..:...|::||:|..:|||:||.||.:||||||..|.|
Human   299 SVVILVPVRLGGETLNPVYVPCVKELLRCELCLGIMGGKPRHSLYFIGYQDDFLLYLDPHYCQPT 363

  Fly   279 GAVAQKTAAAEQDYD-ETYHQKHAARLNFSAMDPSLAVCFLCKTSDSFESLLTKLKEEVLSLCSP 342
            ..|:|      .|:. |::|.....::.|:.||||..|.|.......||:|.::| ..|||..|.
Human   364 VDVSQ------ADFPLESFHCTSPRKMAFAKMDPSCTVGFYAGDRKEFETLCSEL-TRVLSSSSA 421

  Fly   343 A----LFEISQTRAVDW---DTTEDIDWPTM 366
            .    :|.:::..|.|.   |....:..||:
Human   422 TERYPMFTLAEGHAQDHSLDDLCSQLAQPTL 452

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Atg4a	NP_608563.1	Peptidase_C54	66..328	CDD:281417	108/301 (36%)
ATG4D	NP_116274.3	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..60		7/20 (35%)
		Cryptic mitochondrial signal peptide	64..103		4/38 (11%)
		Peptidase_C54	110..411	CDD:281417	109/306 (36%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2674
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG55011
OrthoDB	1	1.010	-	-		D332531at33208
OrthoFinder	1	1.000	-	-		FOG0000466
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100501
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R109
SonicParanoid	1	1.000	-	-		X289
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	8	7.760