Protein Alignment Atg4a and ATG4C

DIOPT Version :9

• Sequence 1: NP_608563.1
• Gene: Atg4a / 33283
• FlyBaseID: FBgn0031298
• Length: 411
• Species: Drosophila melanogaster
• Sequence 2: NP_116241.2
• Gene: ATG4C / 84938
• HGNCID: 16040
• Length: 458
• Species: Homo sapiens
• Alignment Length: 427
• Identity: 125/427 - (29%)
• Similarity: 183/427 - (42%)
• Gaps: 113/427 - (26%)

  Fly    46 RNTDVWVLGKKYNAIQE----------------------LELIRRDIQSRLWCTYRHGFSPLGEV 88
            ||:.|.:|||.|:...|                      :|..|:|..||:|.|||..|..:...
Human    37 RNSPVLLLGKCYHFKYEDEDKTLPAESGCTIEDHVIAGNVEEFRKDFISRIWLTYREEFPQIEGS 101

  Fly    89 QLTTDKGWGCMLRCGQMVLAQALIDLHLGRDWFW------------------------------- 122
            .||||.||||.||.|||:|||.||...|||.|.|
Human   102 ALTTDCGWGCTLRTGQMLLAQGLILHFLGRAWTWPDALNIENSDSESWTSHTVKKFTASFEASLS 166

  Fly   123 ------TP---------------DCRDATY-LKIVNRFEDVRNSFYSIHQIAQMGESQNKAVGEW 165
                  ||               :.|:..| .||::.|.|...:.:.:||:.:.|:...|..|:|
Human   167 GEREFKTPTISLKETIGKYSDDHEMRNEVYHRKIISWFGDSPLALFGLHQLIEYGKKSGKKAGDW 231

  Fly   166 LGPNTVAQILKKLV---RFDDWSSLAIHVAMDSTV----VLDDVYAS-CREGGSWKPLLLIIPLR 222
            .||..||.||:|.|   |..|...:.|:||.|.||    |:|...|| ..:....|.:::::|:|
Human   232 YGPAVVAHILRKAVEEARHPDLQGITIYVAQDCTVYNSDVIDKQSASMTSDNADDKAVIILVPVR 296

  Fly   223 LGITDINPLYVPALKRCLELDSSCGMIGGRPNQALYFLGYVDDEVLYLDPHTTQRTGAVAQKTAA 287
            ||....|..|:..:|..|.|:...|:|||:|.|:.||.|:.||.::|:|||..|....|:.|
Human   297 LGGERTNTDYLEFVKGILSLEYCVGIIGGKPKQSYYFAGFQDDSLIYMDPHYCQSFVDVSIK--- 358

  Fly   288 AEQDYD-ETYHQKHAARLNFSAMDPSLAVCFLCKTSDSFESLLTKLKEEVLSLCSPA------LF 345
               |:. ||:|.....:::|..||||..:.|.|:....|:    :..||:..:...:      ||
Human   359 ---DFPLETFHCPSPKKMSFRKMDPSCTIGFYCRNVQDFK----RASEEITKMLKFSSKEKYPLF 416

  Fly   346 EISQTRAVDWDTTEDIDWPTMPDIDWPAGTSDSDSFA 382
            ......:.|:|.|.             ..|::.|.|:
Human   417 TFVNGHSRDYDFTS-------------TTTNEEDLFS 440

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Atg4a	NP_608563.1	Peptidase_C54	66..328	CDD:281417	106/323 (33%)
ATG4C	NP_116241.2	Peptidase_C54	77..394	CDD:308812	106/322 (33%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2674
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG55011
OrthoDB	1	1.010	-	-		D332531at33208
OrthoFinder	1	1.000	-	-		FOG0000466
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100501
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R109
SonicParanoid	1	1.000	-	-		X289
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	8	7.760