DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Atg4a and Atg4a

DIOPT Version :9

Sequence 1:	NP_608563.1	Gene:	Atg4a / 33283	FlyBaseID:	FBgn0031298	Length:	411	Species:	Drosophila melanogaster
Sequence 2:	XP_038955973.1	Gene:	Atg4a / 678769	RGDID:	1596915	Length:	415	Species:	Rattus norvegicus

Alignment Length:	371	Identity:	150/371 - (40%)
Similarity:	216/371 - (58%)	Gaps:	53/371 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    41 EDIPRRNTDVWVLGKKYNAIQELELIRRDIQSRLWCTYRHGFSPLGEVQLTTDKGWGCMLRCGQM 105
            |:.|..:..||:|||.:....|...:..||.:|||.|||..|||:|....::|.|||||||||||
  Rat    36 EEFPDTDELVWILGKPHLLKTEKSKLLSDISARLWFTYRRKFSPIGGTGPSSDAGWGCMLRCGQM 100

  Fly   106 VLAQALIDLHLGRDWFWTPDC-RDATYLKIVNRFEDVRNSFYSIHQIAQMGESQNKAVGEWLGPN 169
            :||||||..||||||.|.... :...|.:|:..|.|.::..|||||:||||..:.|::|||.|||
  Rat   101 MLAQALICRHLGRDWNWERQKEQPKEYQRILQCFLDRKDCCYSIHQMAQMGVGEGKSIGEWFGPN 165

  Fly   170 TVAQILKKLVRFDDWSSLAIHVAMDSTVVLDDVYASC------------------------REGG 210
            ||||::|||..||:|:|||::|:||:|||::|:...|                        .:|.
  Rat   166 TVAQVIKKLALFDEWNSLAVYVSMDNTVVIEDIKKMCCVLPVGAADTAGESPPDSLIASSQSKGT 230

  Fly   211 S-----WKPLLLIIPLRLGITDINPLYVPALKRCLELDSSCGMIGGRPNQALYFLGYVDDEVLYL 270
            |     |||||||:||||||..|||:|:.|.|.|.::..|.|.:||:||.|.||:|.:.||:::|
  Rat   231 SAPCLAWKPLLLIVPLRLGINQINPVYIEAFKECFKMPQSLGALGGKPNNAYYFIGSLGDELIFL 295

  Fly   271 DPHTTQRTGAVAQKTAAAEQDYDETYH-QKHAARLNFSAMDPSLAVCFLCKTSDSFESLLTKLKE 334
            |||||| |....:::...:   |.|:| .:...|::...:|||:|:.|.||....|::..:.:::
  Rat   296 DPHTTQ-TFVDTEESGLVD---DHTFHCLQSPQRMSILNLDPSVALGFFCKEEKDFDNWCSLVQK 356

  Fly   335 EVLS------------------LCSPALFEISQTRAVDWDTTEDID 362
            |:|.                  ...||..|::.|.|...|:||.::
  Rat   357 EILKENLRMFELVQKHPSHWPPFVPPAKPEVTTTGAEFIDSTEQLE 402

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Atg4a	NP_608563.1	Peptidase_C54	66..328	CDD:281417	132/292 (45%)
Atg4a	XP_038955973.1	Peptidase_C54	58..352	CDD:397471	139/342 (41%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H70873
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG55011
OrthoDB	1	1.010	-	-		D332531at33208
OrthoFinder	1	1.000	-	-		FOG0000466
OrthoInspector	1	1.000	-	-		otm45755
orthoMCL	1	0.900	-	-		OOG6_100501
Panther	1	1.100	-	-	O	PTHR22624
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X289
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	11	10.930