DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Atg4a and atg4a

DIOPT Version :9

Sequence 1:	NP_608563.1	Gene:	Atg4a / 33283	FlyBaseID:	FBgn0031298	Length:	411	Species:	Drosophila melanogaster
Sequence 2:	NP_001019605.1	Gene:	atg4a / 554140	ZFINID:	ZDB-GENE-050522-430	Length:	375	Species:	Danio rerio

Alignment Length:	386	Identity:	165/386 - (42%)
Similarity:	244/386 - (63%)	Gaps:	38/386 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 MESVFEAYLGPDSVLASAVGQAVGSGEPEDIPRRNTDVWVLGKKYNAIQELELIRRDIQSRLWCT 77
            ||:|...|....:|..            ||:|..:..||:||..||...:...:..|::||||.|
Zfish     1 MEAVLAKYENQINVFL------------EDLPDTDEPVWILGACYNVKTKKSELLSDVRSRLWFT 53

  Fly    78 YRHGFSPLGEVQLTTDKGWGCMLRCGQMVLAQALIDLHLGRDWFWTPD-CRDATYLKIVNRFEDV 141
            ||..|||:|....::|.|||||||||||:||||||..||||||.|.|: .:...|.:|::.|.|.
Zfish    54 YRKKFSPIGGTGPSSDAGWGCMLRCGQMILAQALICSHLGRDWRWDPEKHQPKEYQRILDCFLDK 118

  Fly   142 RNSFYSIHQIAQMGESQNKAVGEWLGPNTVAQILKKLVRFDDWSSLAIHVAMDSTVVLDDVYASC 206
            ::|.|||||:||||..:.|:||||.|||||||:||||..||||:||:::|:||:|||::|:...|
Zfish   119 KDSCYSIHQMAQMGVGEGKSVGEWYGPNTVAQVLKKLALFDDWNSLSVYVSMDNTVVIEDIKKLC 183

  Fly   207 ---------REGGSWKPLLLIIPLRLGITDINPLYVPALKRCLELDSSCGMIGGRPNQALYFLGY 262
                     ::...|:||||:||||:||..|||:|:.|||.|.::..|||::||:||.|.||:|:
Zfish   184 VRADLQLQSQQPLDWRPLLLVIPLRMGINSINPVYIQALKECFKMPQSCGVLGGKPNLAYYFIGF 248

  Fly   263 VDDEVLYLDPHTTQRTGAVAQKTAAAEQDYDETYH-QKHAARLNFSAMDPSLAVCFLCKTSDSFE 326
            :|||::||||||||:  ||..::.:|..  |:::| |:...|:..:::|||:|:.|.||:.:.|:
Zfish   249 IDDELIYLDPHTTQQ--AVDTESGSAVD--DQSFHCQRTPHRMKITSLDPSVALGFFCKSEEDFD 309

  Fly   327 SLLTKLKEEVLSLCSPALFEISQTRAVDWDTTEDIDWPTMPD--------IDWPAGTSDSD 379
            |....:::|:|...:..:||:.:.....|.....   ||.|:        |:.|...|:|:
Zfish   310 SWCDLVQQELLKKRNLRMFELVEKHPSHWPPFVP---PTKPEVQTTGAEFIESPDKLSESE 367

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Atg4a	NP_608563.1	Peptidase_C54	66..328	CDD:281417	138/272 (51%)
atg4a	NP_001019605.1	Peptidase_C54	40..313	CDD:281417	139/276 (50%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170581280
Domainoid	1	1.000	295	1.000	Domainoid score	I1463
eggNOG	1	0.900	-	-		E1_KOG2674
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H70873
Inparanoid	1	1.050	321	1.000	Inparanoid score	I2500
OMA	1	1.010	-	-		QHG55011
OrthoDB	1	1.010	-	-		D332531at33208
OrthoFinder	1	1.000	-	-		FOG0000466
OrthoInspector	1	1.000	-	-		otm26220
orthoMCL	1	0.900	-	-		OOG6_100501
Panther	1	1.100	-	-	O	PTHR22624
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R109
SonicParanoid	1	1.000	-	-		X289
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	16	15.800