DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Atg4a and Atg4d

DIOPT Version :9

Sequence 1:	NP_608563.1	Gene:	Atg4a / 33283	FlyBaseID:	FBgn0031298	Length:	411	Species:	Drosophila melanogaster
Sequence 2:	NP_705811.8	Gene:	Atg4d / 235040	MGIID:	2444308	Length:	474	Species:	Mus musculus

Alignment Length:	457	Identity:	135/457 - (29%)
Similarity:	207/457 - (45%)	Gaps:	99/457 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    21 LGPDSVLASAVGQA-VGSGEPEDIPR-------------------------RNTDVWVLGKKYNA 59
            |||.....:|:|.: ....||:::.:                         :.:.|.:.|:.|:.
Mouse    39 LGPSGSGVAALGSSGTDPAEPDEVDKFKAKFLTAWNNVKYGWAVKSRTSFSKISTVHLCGRCYHF 103

  Fly    60 IQE--LELIRRDIQSRLWCTYRHGFSPLGEVQLTTDKGWGCMLRCGQMVLAQALIDLHLGRDWFW 122
            ..|  ::..:||..||||.|||..|.||....||:|.|||||||.|||:|||.|:...|.|||.|
Mouse   104 EGEGDIQRFQRDFVSRLWLTYRRDFPPLAGGSLTSDCGWGCMLRSGQMMLAQGLLLHFLPRDWRW 168

  Fly   123 ---------------TPD-CR-------------------DATYLKIVNRFEDVRNSFYSIHQIA 152
                           :|. ||                   |..:.:||:.|.|...:.:.:|::.
Mouse   169 VEGTGLASSEMPGPASPSRCRGPGRRGPPRWTQGALEMEQDRWHRRIVSWFADHPRAPFGLHRLV 233

  Fly   153 QMGESQNKAVGEWLGPNTVAQILKKLVR-FDDWSSLAIHVAMDSTVVLDDVYASCR---EGGSWK 213
            ::|.|..|..|:|.||:.||.||:|.|. ..:.|.|.::|:.|.||...||.....   ....||
Mouse   234 ELGRSSGKKAGDWYGPSVVAHILRKAVESCSEVSRLVVYVSQDCTVYKADVARLLSWPDPTAEWK 298

  Fly   214 PLLLIIPLRLGITDINPLYVPALKRCLELDSSCGMIGGRPNQALYFLGYVDDEVLYLDPHTTQRT 278
            .:::::|:|||...:||:|||.:|..|..:...|::||:|..:|||:||.||.:||||||..|.|
Mouse   299 SVVILVPVRLGGETLNPVYVPCVKELLRSELCLGIMGGKPRHSLYFIGYQDDFLLYLDPHYCQPT 363

  Fly   279 GAVAQKTAAAEQDYDETYHQKHAARLNFSAMDPSLAVCFLCKTSDSFESLLTKLKEEVLSLCSPA 343
            ..|:|.:...     |::|.....::.|:.||||..|.|.......||:|.::|. .:||..|..
Mouse   364 VDVSQPSFPL-----ESFHCTSPRKMAFAKMDPSCTVGFYAGNRKEFETLCSELM-RILSSSSVT 422

  Fly   344 ----LFEISQTRAVDWDTTEDIDWPTMPDIDWPAGTSDSDSFAIVEESGRDSDAGCSGAIGSGKK 404
                :|.:::..|.|..........:.|.:..|                      |:|.:...|:
Mouse   423 ERYPMFTVAEGHAQDHSLDALCTQLSQPTLRLP----------------------CTGRLLKAKR 465

  Fly   405 PS 406
            ||
Mouse   466 PS 467

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Atg4a	NP_608563.1	Peptidase_C54	66..328	CDD:281417	109/300 (36%)
Atg4d	NP_705811.8	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..60		6/20 (30%)
		Cryptic mitochondrial signal peptide. /evidence=ECO:0000250	64..103		3/38 (8%)
		Peptidase_C54	110..411	CDD:281417	110/305 (36%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	175..198		3/22 (14%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2674
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG55011
OrthoDB	1	1.010	-	-		D332531at33208
OrthoFinder	1	1.000	-	-		FOG0000466
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100501
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R109
SonicParanoid	1	1.000	-	-		X289
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	8	7.760