Protein Alignment Atg4a and ATG4B

DIOPT Version :10

• Sequence 1: NP_608563.1
• Gene: Atg4a / 33283
• FlyBaseID: FBgn0031298
• Length: 411
• Species: Drosophila melanogaster
• Sequence 2: XP_005247049.2
• Gene: ATG4B / 23192
• HGNCID: 20790
• Length: 415
• Species: Homo sapiens
• Alignment Length: 351
• Identity: 161/351 - (45%)
• Similarity: 212/351 - (60%)
• Gaps: 56/351 - (15%)

  Fly    39 EPEDIPRRNTDVWVLGKKYNAIQELELIRRDIQSRLWCTYRHGFSPLGEVQLTTDKGWGCMLRCG 103
            |.||.|..:..||:||:||:...|.:.|..|:.||||.|||..|..:|....|:|.|||||||||
Human    15 EFEDFPETSEPVWILGRKYSIFTEKDEILSDVASRLWFTYRKNFPAIGGTGPTSDTGWGCMLRCG 79

  Fly   104 QMVLAQALIDLHLGRDWFWT-----PDCRDATYLKIVNRFEDVRNSFYSIHQIAQMGESQNKAVG 163
            ||:.||||:..||||||.||     ||    :|..::|.|.|.::|:||||||||||..:.|::|
Human    80 QMIFAQALVCRHLGRDWRWTQRKRQPD----SYFSVLNAFIDRKDSYYSIHQIAQMGVGEGKSIG 140

  Fly   164 EWLGPNTVAQILKKLVRFDDWSSLAIHVAMDSTVVLDDVYASCREG------------------- 209
            :|.|||||||:||||..||.|||||:|:|||:|||::::...||..
Human   141 QWYGPNTVAQVLKKLAVFDTWSSLAVHIAMDNTVVMEEIRRLCRTSVPCAGATAFPADSDRHCNG 205

  Fly   210 -----------GSWKPLLLIIPLRLGITDINPLYVPALKRCLELDSSCGMIGGRPNQALYFLGYV 263
                       ..|:||:|:||||||:||||..||..||.|..:..|.|:|||:||.|.||:|||
Human   206 FPAGAEVTNRPSPWRPLVLLIPLRLGLTDINEAYVETLKHCFMMPQSLGVIGGKPNSAHYFIGYV 270

  Fly   264 DDEVLYLDPHTTQRTGAVAQKTAAAEQD----YDETYHQKH-AARLNFSAMDPSLAVCFLCKTSD 323
            .:|::||||||||        .|....|    .||::|.:| ..|::.:.:|||:||.|.|||.|
Human   271 GEELIYLDPHTTQ--------PAVEPTDGCFIPDESFHCQHPPCRMSIAELDPSIAVGFFCKTED 327

  Fly   324 SFESLLTKLKEEVLSLCSPAL--FEI 347
            .|.....::|:  |||...||  ||:
Human   328 DFNDWCQQVKK--LSLLGGALPMFEL 351

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Atg4a	NP_608563.1	Peptidase_C54	63..328	CDD:460915	142/304 (47%)
ATG4B	XP_005247049.2	Peptidase_C54	39..335	CDD:460915	142/307 (46%)