Protein Alignment ast and Fam120b

DIOPT Version :10

• Sequence 1: NP_523451.2
• Gene: ast / 33282
• FlyBaseID: FBgn0015905
• Length: 854
• Species: Drosophila melanogaster
• Sequence 2: NP_077165.2
• Gene: Fam120b / 67544
• MGIID: 1914794
• Length: 786
• Species: Mus musculus
• Alignment Length: 741
• Identity: 151/741 - (20%)
• Similarity: 246/741 - (33%)
• Gaps: 240/741 - (32%)

  Fly     1 MGVRGLTSYIAQRAEIYLKPH-----ELHSTA-------------LVIDGDNLSCNLYKDVTGSY 47
            ||||||..::....     ||     .:|..|             :|:|.  :.|..|.....|:
Mouse     1 MGVRGLQGFVGSTC-----PHICTIVNIHELAERHRNKYPGCTPTIVVDA--MCCLRYWYTAESW 58

  Fly    48 SAFGGDYDDFYRAVVQFFQVLAECNIRPYVLMDGGYEERKL-RTVSTRLRN--KISVI------K 103
             ..||.:.::|.|:..|........|:.....||..|..|. ..|..||:|  :||.|      |
Mouse    59 -VCGGQWREYYCALRNFVAAFTSAGIKLIFFFDGMVEPGKRDEWVKRRLKNNREISKIFHYIKSK 122

  Fly   104 KINPNASITLFPLHLKEVFVDAVRDCGVPVMRCVFEADDELAALARKLNC-PVLSYDSDFYIHNV 167
            :..|..::...|..|......|::..|......:.|||.|:|:...:.|| .:|..|:|:.|::.
Mouse   123 RDQPGRNMFFIPSGLAIFTRFALKTLGQETFCSLQEADYEVASYGLQHNCLGILGEDTDYLIYDT 187

  Fly   168 -KYIPLITLTVKVLTKQVKDKNSSNQKDSRDLRHCEAKNVKKRTRANKIVTGIQTTGLTASTKGS 231
             .|..:..|.::.|               :.:..|..|
Mouse   188 CPYFSIGDLCLESL---------------QTIMLCREK--------------------------- 210

  Fly   232 SKTYKYLDCCIYRVSHLCGRGTLSPEKLPLFAALLGNDYIARSAFKNF-------FAAGMGKAGR 289
                            ||....|....|||.|.|||||....|.|::|       :|:....||:
Mouse   211 ----------------LCESLGLRVADLPLLACLLGNDITPESMFESFRYKCLSSYASVKENAGK 259

  Fly   290 ------------SRKLKLQQ--KRIQVILTWLKEETAESAL--AKVLSRLKKNQRDS-LVSQVNA 337
                        |:.|.|.|  |:|:.:|..    ....||  ..|.|.|...|:.. ||.:...
Mouse   260 KGNIILAVSDYISKVLHLYQGEKKIEEMLPL----GPNKALFYKGVTSYLLPGQKSPWLVQKPKG 320

  Fly   338 AISGYSNELCHAYDYFDEHYENAFPYIEPVSEEE---CSDDEHSS-----SSDEKFSDVE---EG 391
            .|:.                :.....:.|.|::|   |.|.|...     ::.|...:|.   :.
Mouse   321 MITD----------------KQQMVSLNPESKQEVPMCIDPEFKQEVPVCTNPESMQEVPMCMDP 369

  Fly   392 EDQEEAD--NQDEEQQEENQDVDS----------GDEEEEEADEGLELEVEDKTLLFPQWFLDKL 444
            |..:||.  ...|.:||.....||          ..|.:::...|::.|..          |:.|
Mouse   370 EPNQEASMCTDPESKQEVPMCTDSESKPEVSQYTNPESKQKLPSGIDTEFN----------LEAL 424

  Fly   445 YPAHLPRSFVDLMHLRKYINNPQIEHFPFHDSNEVALPILNYVFALLHHVECE-----------K 498
            ...|......|:|.:     .|:|:.......:|: |.:     |.:|||..|           :
Mouse   425 MCTHPEFKQEDVMDM-----EPEIKQVTMVSESEI-LKV-----ARMHHVHSESYLVYNILSSGE 478

  Fly   499 IEL--PLEVDMDIEGSTVPYLTYLTRALRVTNVRYFKM------------PIEKK-PAYPFDPLS 548
            ||.  .||.::|   ..:|...::.|.:|   .|.:.:            |:.|: ..||.:.|.
Mouse   479 IECSNTLEDELD---QALPSQAFIYRPVR---QRVYALLLGDWKDGASTGPVVKEWFVYPGNSLK 537

  Fly   549 -PD-ARHLRAVFEDNAPNADT--------------EKLFS---------KLDQLPEDLRLYFLAI 588
             || .|.|:...:...|:.:.              :.|.:         :|..:...||.....:
Mouse   538 HPDLVRPLQMTVQGGTPSLEVLWLSQEPAVQAQRLDTLLACFNLSSSREELQAVESPLRALCCLL 602

  Fly   589 IYWLHRSEHCDLLHLHSLILSLVVLR 614
            ||...:.:...|..||:.|...:.|:
Mouse   603 IYLFVQVDTLSLEDLHAFIAQALCLQ 628

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ast	NP_523451.2	PIN_asteroid-like	28..182	CDD:350243	42/164 (26%)
Fam120b	NP_077165.2	Mediates transactivation of PPARG	1..561		140/672 (21%)
		PIN_FAM120B-like	5..213	CDD:350239	51/273 (19%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	371..413		8/41 (20%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	738..786