DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ast and Aste1

DIOPT Version :9

Sequence 1:	NP_523451.2	Gene:	ast / 33282	FlyBaseID:	FBgn0015905	Length:	854	Species:	Drosophila melanogaster
Sequence 2:	NP_079927.2	Gene:	Aste1 / 66595	MGIID:	1913845	Length:	672	Species:	Mus musculus

Alignment Length:	878	Identity:	195/878 - (22%)
Similarity:	327/878 - (37%)	Gaps:	254/878 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MGVRGLTSYIAQRAEIYLKPHELHSTALVIDGDNLSCNL--YKDVTGSYSAFGGDYDDFYRAVVQ 63
            ||:|||.|::...:..:....:|.:|.|:|||.:|...|  ..|:...|   |||||.|...|.:
Mouse     1 MGIRGLMSFVEDYSNEFFVDLKLRNTKLIIDGYSLFHRLCFNSDLELRY---GGDYDLFADVVQK 62

  Fly    64 FFQVLAECNIRPYVLMDGGYE--ERKLRTVSTRLRNKISVIKKINPNASITLFPLHLKEVFVDAV 126
            ||:.|..|:|.|||::|||.:  ::||.|:..|.:.||...:.::......:.||.::|||:..:
Mouse    63 FFESLFVCHICPYVVLDGGCDISDKKLTTLKDRAKEKIQAARSLSLGGGGNVCPLLIREVFIQVL 127

  Fly   127 RDCGVPVMRCVFEADDELAALARKLNCPVLSYDSDFYIHNVK--YIPLITLTVKVLTKQVKDKNS 189
            ....|..::...|||.::..||...||||||.||||.|.:::  :..|         ...:.:|.
Mouse   128 IRLEVCFVQSFSEADRDIMTLANHWNCPVLSSDSDFCIFDLRSGFCSL---------NSFQWRNL 183

  Fly   190 SNQKDSRDLRHCEAKNVKKRTRANKIVTGIQTTGLTASTKGSSKTYKYLDCCIYRVSHLCGR-GT 253
            :..||::|.                                      |:....:.::..|.. ..
Mouse   184 NTIKDTQDY--------------------------------------YIPARSFSLNAFCHYFNN 210

  Fly   254 LSPEKLPLFAALLGNDYIARSAFKNFFAAGMGKAGRSRKLKLQQK-----RIQVILTWLKE-ETA 312
            ::...|||||.|.|||::.......|.:        ..:|.|..|     |:..:|.||.. :..
Mouse   211 MNKALLPLFAVLCGNDHVNLPIMDTFIS--------KVRLPLSSKGRRYHRVLGLLNWLSHFDDP 267

  Fly   313 ESALAKVLSRLKKNQRDSLVSQVNAAISGYSNELCHAYDYFDEHYENAFPYIEPVSEEECSDDEH 377
            ..||..||..|.|..|:::...:..::..|........|:|  .|.:   |:       |:|
Mouse   268 TEALDNVLKSLPKKSRENVKELLCCSMEEYQQSPVKLQDFF--QYGS---YV-------CTD--- 317

  Fly   378 SSSSDEKFSDVEEGEDQEEADNQDEEQQEENQDVDSGDEEEEEADEGLELEVEDKTLLFPQWFLD 442
                                                      .:|.||           |:|.|.
Mouse   318 ------------------------------------------ASDLGL-----------PEWVLG 329

  Fly   443 KLYPAHLPRSFVDLMHLRKYINNPQIEHFPFHDSNEVALPILNYVFALL----HHVECEKIELPL 503
            .|....||....|.:.||:...:.|:|:....:::.::.||...::.||    .|.|
Mouse   330 ALAKGQLPPFISDALVLRRTFLHTQVENMQRPNAHRISQPIRQIIYGLLLNGPSHAE-------- 386

  Fly   504 EVDMDIEGSTVPYLTYLTRALRVTNVRYFKMPIEKKPAYPFDPLSPDARHLRAVFEDNAPNADTE 568
                ||..:|:|     ::.|....|......|:....|. ..|..|...|..:.|  .|.|..:
Mouse   387 ----DIAQNTLP-----SQLLAFNEVERIDTNIKTSTVYA-KQLLKDQCDLSKLAE--LPLARRQ 439

  Fly   569 KLFSK--------LDQLPEDLRLYFLAIIYWLHRSE-HCDLLHLHSLILSLVVLRTIDVTIPAER 624
            .|..:        |:.:|..|:|......|||..:| ...|.||.:|:|.::            |
Mouse   440 MLLLEALKVKQVVLESIPTFLKLPIAVTCYWLQSTEAKAKLHHLQALLLGML------------R 492

  Fly   625 EVKTFLKRFGKTLKAERAVRDKEAAEGIKRG----IKPALLELSVPDRMAHVPKSDCYLTQERLL 685
            |             ...|:.:....|..:||    :...|.::..|.|..  |:.|
Mouse   493 E-------------PLHAIVNSPGTEDPQRGGAKMLYEELCQVKAPMRPG--PRVD--------- 533

  Fly   686 PHFHMQEIFKKKFDLYSTTVIHAFAEFQAVVYQLNGLNSLLDFPLLSPRMNQLYCGAFLYNMYDV 750
                             ....|.|.::|:.:.....||.||..||..|.:..||.|:.::.:...
Mouse   534 -----------------LDTAHVFCQWQSCLQMGLYLNQLLSTPLPEPNLTWLYNGSLVHRLCQQ 581

  Fly   751 LRNRADVRYHVENFLLPDSKLMFDFYCYLYDWCAEFIPTWKRLEVDPTAAKALQKKRLKKQRQAA 815
            |...:.|...:.  |.|::|.:::   :|::....:.|.  .|.:..|.:|: :|||.||
Mouse   582 LPASSSVESLLS--LCPEAKQLYE---HLFNATKSYAPA--ELFLPKTKSKS-KKKRQKK----- 633

  Fly   816 RKVELREAIADPNAEMVEDADPENDFFDLNNKF 848
             ||          |.:...||.:: ::|.:|:|
Mouse   634 -KV----------ASLGTTADAKH-WYDRSNRF 654

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ast	NP_523451.2	XPG_I_2	115..>354	CDD:289575	55/247 (22%)
Aste1	NP_079927.2	PIN_SF	28..181	CDD:391943	55/164 (34%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167839828
Domainoid	1	1.000	67	1.000	Domainoid score	I9860
eggNOG	1	0.900	-	-		E1_28IEJ
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	147	1.000	Inparanoid score	I4398
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0006050
OrthoInspector	1	1.000	-	-		oto94885
orthoMCL	1	0.900	-	-		OOG6_103497
Panther	1	1.100	-	-	LDO	PTHR15665
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4474
SonicParanoid	1	1.000	-	-		X4965
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	14	13.780