Protein Alignment ast and Fam120b

DIOPT Version :10

• Sequence 1: NP_523451.2
• Gene: ast / 33282
• FlyBaseID: FBgn0015905
• Length: 854
• Species: Drosophila melanogaster
• Sequence 2: NP_001100936.2
• Gene: Fam120b / 308218
• RGDID: 1310304
• Length: 785
• Species: Rattus norvegicus
• Alignment Length: 749
• Identity: 148/749 - (19%)
• Similarity: 243/749 - (32%)
• Gaps: 257/749 - (34%)

  Fly     1 MGVRGLTSYIAQRAEIYLKPH-----ELHSTA-------------LVIDGDNLSCNLYKDVTGSY 47
            ||||||..::....     ||     .||..|             :|:|.  :.|..|.....|:
  Rat     1 MGVRGLQGFVGSTC-----PHICTTVNLHELAESHRAKYPGSTPTIVVDA--MCCLRYWYTAESW 58

  Fly    48 SAFGGDYDDFYRAVVQFFQVLAECNIRPYVLMDGGYEERKL-RTVSTRLRN--KISVI------K 103
             ..||.:.::|.|:..|........|:.....||..|..|. ..|..||:|  :||.|      |
  Rat    59 -VCGGQWREYYSALRDFLAAFTSAGIKLIFFFDGTVEPGKRDEWVKRRLKNNREISRIFHYIKSK 122

  Fly   104 KINPNASITLFPLHLKEVFVDAVRDCGVPVMRCVFEADDELAALARKLNC-PVLSYDSDFYIHNV 167
            :..|..::...|..|......|::..|......:.|||.|:|:...:.|| .:|..|:|:.|::.
  Rat   123 REQPGRNMFFIPSGLAIFTRFALKSLGQETFCSLQEADYEVASYGLQHNCLGILGEDTDYLIYDT 187

  Fly   168 -KYIPLITLTVKVLTKQVKDKNSSNQKDSRDLRHCEAKNVKKRTRANKIVTGIQTTGLTASTKGS 231
             .|:.:..|.::.|               :.:..|..|
  Rat   188 CPYLSIGDLCLESL---------------QTILLCREK--------------------------- 210

  Fly   232 SKTYKYLDCCIYRVSHLCGRGTLSPEKLPLFAALLGNDYIARSAFKNF-------FAAGMGKAGR 289
                            ||....|....|||.|.|||||......|::|       :|:....||:
  Rat   211 ----------------LCESLGLRVSDLPLLACLLGNDITPEGMFESFRYKCLSSYASVKENAGK 259

  Fly   290 ------------SRKLKLQQ--KRIQVIL-----------------------TWLKEETAESALA 317
                        |:.|.|.|  |:|:.:|                       .||.::.......
  Rat   260 KGNIILAVSDYISKVLHLYQGEKKIEEMLPLGPNKALFYKGVTSYLLPGQKSPWLVQKPKSIITD 324

  Fly   318 KVLSRLKKNQRDSLVSQVNAAISGYSNELCHAYDYFDEHYENAFPY-IEPVSEEE---CSDDEHS 378
            |.::.|....:..:             .:|     .|..::...|. ..|.|.:|   |.|.|
  Rat   325 KQMASLNPGSKQEV-------------PMC-----IDPEFKQEVPVCTNPESMQEVPMCMDPE-- 369

  Fly   379 SSSDEKFSDVEEGEDQEEADNQDEEQQEENQDVDSGDEEEEEADEGLELEVEDK----TLLFPQW 439
                         .:||.:...|.|.:.|   |....:.|.:.:..|....|.|    :.:.|:.
  Rat   370 -------------PNQEASVCMDRESKPE---VPMCTDPESKPEVPLYTNPESKQKSPSEIDPKC 418

  Fly   440 FLDKL---YPAHLPRSFVDLMHLRKYINNPQIEHFPFHDSNEVALPILNYVFALLHHVECE---- 497
            .|:.|   ||.......:|:        .|:|:.......:|: |.:     |.:|||..|
  Rat   419 NLEALTCTYPEVKQEDAMDM--------EPEIKQATMVSESEI-LKV-----ARMHHVHSESYLV 469

  Fly   498 -------KIEL--PLEVDMDIEGSTVPYLTYLTRALRVTNVRYFKM------------PIEKK-P 540
                   :||.  .||.::|   ..:|...::.|.:|   .|.:.:            |:.|: .
  Rat   470 YNILSSGEIECSNTLEDELD---QALPSQAFIYRPVR---QRVYSLLLEDWKDGASTGPVVKEWF 528

  Fly   541 AYPFDPLS-PD-ARHLRAVFEDNAPN-----------ADTEKLFS------------KLDQLPED 580
            .||.:.|. || .|.|:...:...|:           |...:|.:            :|..:...
  Rat   529 VYPGNSLKHPDLVRPLQMTVQGGTPSLEVLWLSQEPAAQARRLDTLLACFNLSSSREELQSVESP 593

  Fly   581 LRLYFLAIIYWLHRSEHCDLLHLHSLILSLVVLR 614
            ||.....:||...:.:...|..||:.|...:.|:
  Rat   594 LRALCCLLIYLFVQVDTLSLEDLHAFIAQALCLQ 627

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ast	NP_523451.2	PIN_asteroid-like	28..182	CDD:350243	42/164 (26%)
Fam120b	NP_001100936.2	PIN_FAM120B-like	5..213	CDD:350239	52/273 (19%)