DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ast and ASTE1

DIOPT Version :9

Sequence 1:	NP_523451.2	Gene:	ast / 33282	FlyBaseID:	FBgn0015905	Length:	854	Species:	Drosophila melanogaster
Sequence 2:	NP_001275879.1	Gene:	ASTE1 / 28990	HGNCID:	25021	Length:	704	Species:	Homo sapiens

Alignment Length:	887	Identity:	192/887 - (21%)
Similarity:	308/887 - (34%)	Gaps:	290/887 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MGVRGLTSYIAQRAEIYLKPHELHSTALVIDGDNL------SCNLYKDVTGSYSAFGGDYDDFYR 59
            ||:|||.|::...:..:....:|..|.:||||..|      |.||  |:     .:|||||.|..
Human     1 MGIRGLMSFVEDHSNEFFTDLKLRDTKIVIDGYALFHRLCFSSNL--DL-----RYGGDYDSFAD 58

  Fly    60 AVVQFFQVLAECNIRPYVLMDGGYE--ERKLRTVSTRLRNKISVIKKINPNASITLFPLHLKEVF 122
            .|.:||:.|..|||.|||::|||.:  ::||.|:..|.|.||.:...::...|..:.||.::|||
Human    59 VVQKFFESLFACNICPYVVLDGGCDISDKKLTTLKDRAREKIQMAHSLSVGGSGYVCPLLIREVF 123

  Fly   123 VDAVRDCGVPVMRCVFEADDELAALARKLNCPVLSYDSDFYIHNVK--YIPLITLTVKVLTKQVK 185
            :..:....|..::|..|||.::..||...||||||.||||.|.::|  :.||
Human   124 IQVLIKLRVCFVQCFSEADRDIMTLANHWNCPVLSSDSDFCIFDLKTGFCPL------------- 175

  Fly   186 DKNSSNQKDSRDLRHCEAKNVKKRTRANKIVTGIQTTGLTASTKGSSKTYKYLDCCIYRVSHLCG 250
              ||...::...:                              ||   |..|:....:.:...|.
Human   176 --NSFQWRNMNTI------------------------------KG---TQNYIPAKCFSLDAFCH 205

  Fly   251 R-GTLSPEKLPLFAALLGNDYIARSAFKNFFAAGMGKAGRSRKLKLQQKRIQVILTWLKE-ETAE 313
            . ..::...|||||.|.|||::.....:.|.:......|.:.....:..||..:|.||.. ....
Human   206 HFSNMNKALLPLFAVLCGNDHVNLPIMETFLSKARLPLGATSSKGRRHHRILGLLNWLSHFANPT 270

  Fly   314 SALAKVLSRLKKNQRDSLVSQVNAAISGYSNELCHAYDYFDEHYENAFPYIEPVSEEECSDDEHS 378
            .||..||..|.|..|:::...:..::..|........|:|     ....|:.|
Human   271 EALDNVLKYLPKKDRENVKELLCCSMEEYQQSQVKLQDFF-----QCGTYVCP------------ 318

  Fly   379 SSSDEKFSDVEEGEDQEEADNQDEEQQEENQDVDSGDEEEEEADEGLELEVEDKTLLFPQWFLDK 443
                                                        :.|.|.:       |:|.|..
Human   319 --------------------------------------------DALNLGL-------PEWVLVA 332

  Fly   444 LYPAHLPRSFVDLMHLRKYINNPQIEHFPFHDSNEVALPILNYVFALLHHV-------------- 494
            |....|.....|.:.||:.|...|:|:....:::.::.||...::.||.:.
Human   333 LAKGQLSPFISDALVLRRTILPTQVENMQQPNAHRISQPIRQIIYGLLLNASPHLDKTSWNALPP 397

  Fly   495 ------ECEKIELPLE------VDMDIEGSTVPYLTYLT---RALRVTNVRYFKMPIEKKPAYPF 544
                  |.|:|...:.      |::..:.|.:..||.|:   |.:.:......|..|
Human   398 QPLAFSEVERINKNIRTSIIDAVELAKDHSDLSRLTELSLRRRQMLLLETLKVKQTI-------- 454

  Fly   545 DPLSPDARHLRAVFEDNAPNADTEKLFSKLDQLPEDLRLYFLAIIYWL-HRSEHCDLLHLHSLIL 608
                                         |:.:|..|:|......||| |......|.||.||:|
Human   455 -----------------------------LEPIPTSLKLPIAVSCYWLQHTETKAKLHHLQSLLL 490

  Fly   609 SLVVLRTID-VTIPAEREVKTFLKRFGKTLKAERAVRDKEAAEGIKRGIKPALLELSVPDRMAHV 672
            :::|...|. :..|.:.|::   :...|.|.||        .:.:|
Human   491 TMLVGPLIAIINSPGKEELQ---EDGAKMLYAE--------FQRVK------------------- 525

  Fly   673 PKSDCYLTQERLLPHFHMQEIFKKKFDLYSTTVIHAFAEFQAVVYQLNGLNSLLDFPLLSP---- 733
                   .|.||          ..:.||   ...|.|.::|:.:.....||.||..||..|
Human   526 -------AQTRL----------GTRLDL---DTAHIFCQWQSCLQMGMYLNQLLSTPLPEPDLTR 570

  Fly   734 ---------------------RMNQLYCGAFLYNMYDVLRNRADVRYHVENFL--LPDSKLMFDF 775
                                 .:::||.|:.::.:...|.....    ||:.|  .|::|.:::
Human   571 PSAFNTLNEDIWTHTKYGGTLHVSRLYSGSLVHGLCQQLLASTS----VESLLSICPEAKQLYE- 630

  Fly   776 YCYLYDWCAEFIPTWKRLEVDPTAAKALQKKRLKKQRQAARK 817
              ||::....:.|....|   |......:|||.|||..:..|
Human   631 --YLFNATRSYAPAEIFL---PKGRSNSKKKRQKKQNTSCSK 667

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ast	NP_523451.2	XPG_I_2	115..>354	CDD:289575	58/242 (24%)
ASTE1	NP_001275879.1	PIN_SF	1..>97	CDD:301351	40/102 (39%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165149774
Domainoid	1	1.000	72	1.000	Domainoid score	I9408
eggNOG	1	0.900	-	-		E1_28IEJ
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	197	1.000	Inparanoid score	I3814
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D200053at33208
OrthoFinder	1	1.000	-	-		FOG0006050
OrthoInspector	1	1.000	-	-		oto91307
orthoMCL	1	0.900	-	-		OOG6_103497
Panther	1	1.100	-	-	LDO	PTHR15665
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4474
SonicParanoid	1	1.000	-	-		X4965
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	14	13.790