Protein Alignment gNacalpha and NACA

DIOPT Version :10

• Sequence 1: NP_608561.2
• Gene: gNacalpha / 33279
• FlyBaseID: FBgn0031296
• Length: 347
• Species: Drosophila melanogaster
• Sequence 2: NP_001352825.1
• Gene: NACA / 4666
• HGNCID: 7629
• Length: 2078
• Species: Homo sapiens
• Alignment Length: 390
• Identity: 122/390 - (31%)
• Similarity: 173/390 - (44%)
• Gaps: 81/390 - (20%)

  Fly     4 KQKMKKAAQMATAAEKLKTAAEKSKTAADNVVAKEKPAEEASPSPSGSGKKGKPKATQKPNVAKA 68
            |...|........|..|....:.||||         ..::||.||.|.....:.||: .|..|.|
Human  1723 KNGSKGPLSTVAPAPLLPVQKDSSKTA---------KGKDASHSPKGPLAPPESKAS-TPLTAAA 1777

  Fly    69 LQKEISSSEDA-LDVKNKPPAGFSGA------------------------KGKPHIMGQMDPAYR 108
            .:|.:...|.| :.....||.....|                        ..||     :.||..
Human  1778 FEKVLPKPESASVSAAPSPPVSLPLAPSPVPTLPPKQQFLPSSPGLVLESPSKP-----LAPADE 1837

  Fly   109 NKIKKLMSLAKQLPPNVFS--------LPNSQKEEGAS------AAKSCVVEDDQ----STDSDD 155
            :::..|      :||...|        |.|....:.|.      :||..|.::::    .:|||:
Human  1838 DELLPL------IPPEPISGGVPFQSVLVNMPTPKSAGIPVPTPSAKQPVTKNNKGSGTESDSDE 1896

  Fly   156 A-PDLVEADPKETQPDEQGQLGTVAVRTRE---VSKQSRGERKARRILMKLDLKPMENVARVTMK 216
            : |:|.|.|..:. ..:|.||...|....|   .:||||.|:|||:.:.||.|:.:..|.|||::
Human  1897 SVPELEEQDSTQA-TTQQAQLAAAAEIDEEPVSKAKQSRSEKKARKAMSKLGLRQVTGVTRVTIR 1960

  Fly   217 KGKNILLYIDQPDVYRVAHSSTYIFFGEICVEDTSTTSVASQAAVKAAERFRGTSPAGRQGNEDG 281
            |.||||..|.:||||:...|.|||.|||..:||.|     .||.:.|||:|:....|.....|:.
Human  1961 KSKNILFVITKPDVYKSPASDTYIVFGEAKIEDLS-----QQAQLAAAEKFKVQGEAVSNIQENT 2020

  Fly   282 KAPGEESPHDDDDDENDGEDADAMGLHAKDIELVQMQAACSRKKAIQALLKNDNDVVNAIMALTV 346
            :.|..:       :|::.|:.|..|:..||||||..||..||.||::||..|.||:|||||.||:
Human  2021 QTPTVQ-------EESEEEEVDETGVEVKDIELVMSQANVSRAKAVRALKNNSNDIVNAIMELTM 2078

  Fly   347  346
            Human  2079  2078

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
gNacalpha	NP_608561.2	NAC_NACA	203..249	CDD:409233	22/45 (49%)
		UBA_NAC_euk	309..345	CDD:270541	22/35 (63%)
NACA	NP_001352825.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..21
		PHA03247	<2..395	CDD:223021
		PRK12323	<8..>184	CDD:481241
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	37..96
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	595..614
		PHA03247	<720..1121	CDD:223021
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	732..1944		58/242 (24%)
		PHA03247	<1273..1839	CDD:223021	28/130 (22%)
		PXLXP. /evidence=ECO:0000250|UniProtKB:P70670	1841..1845		1/9 (11%)
		Required for DNA-binding. /evidence=ECO:0000250|UniProtKB:P70670	1932..1943		7/10 (70%)
		NAC_NACA	1947..1994	CDD:409233	23/46 (50%)
		UBA_NACA_NACP1	2032..2077	CDD:270598	25/44 (57%)