DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment IA-2 and PTP1

DIOPT Version :9

Sequence 1:	NP_608562.4	Gene:	IA-2 / 33277	FlyBaseID:	FBgn0031294	Length:	1319	Species:	Drosophila melanogaster
Sequence 2:	NP_010051.1	Gene:	PTP1 / 851368	SGDID:	S000002389	Length:	335	Species:	Saccharomyces cerevisiae

Alignment Length:	324	Identity:	88/324 - (27%)
Similarity:	131/324 - (40%)	Gaps:	76/324 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly   961 QREWEALCRY-----EAEPSAREAAS-------------QPQCAGLNRPGAPLPYDHSRVVLNHL 1007
            ||:.:.|.::     :.:...|||.:             :|:....||....:||:.:||   ||
Yeast    10 QRDTDLLGKFKFIQNQEDGRLREATNGTVNSRWSLGVSIEPRNDARNRYVNIMPYERNRV---HL 71

  Fly  1008 ANAEGLDYVNASTITDHDP----RAPAYVAAQGPLPSTLAHFWQMIWEQ---GAVVIVALCRLQE 1065
            ....|.||:|||.:..:.|    ....|:|.|||...|...||||.:..   ..:|||.:..|.|
Yeast    72 KTLSGNDYINASYVKVNVPGQSIEPGYYIATQGPTRKTWDQFWQMCYHNCPLDNIVIVMVTPLVE 136

  Fly  1066 NGEVACARYWPEEGAE----VYHIYE----------------VHLVSEHIWCDDYLVRSFYL--K 1108
            .....|.:|||..|.:    :...:|                :..|:.|...|.|.|....|  .
Yeast   137 YNREKCYQYWPRGGVDDTVRIASKWESPGGANDMTQFPSDLKIEFVNVHKVKDYYTVTDIKLTPT 201

  Fly  1109 NLRTSETRTVTQFHFLSWPHMGVPAQAKALLDF---RRKVNKSYRGRRSCPIVVHGSAGAGRTGV 1170
            :......:||..|:|..|..|..|.:...:::.   ...:|.     |..||:||.|||.||||.
Yeast   202 DPLVGPVKTVHHFYFDLWKDMNKPEEVVPIMELCAHSHSLNS-----RGNPIIVHCSAGVGRTGT 261

  Fly  1171 YILLD------LVLERMNKGAREIDIAATLEHLRD-----------QRAGVVATRQQFEFVLMA 1217
            :|.||      |..:.:.:.:|..| .||.|:.||           ||..:|.|:.||.|:..|
Yeast   262 FIALDHLMHDTLDFKNITERSRHSD-RATEEYTRDLIEQIVLQLRSQRMKMVQTKDQFLFIYHA 324

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
IA-2	NP_608562.4	Receptor_IA-2	708..795	CDD:288410
		PTPc	960..1220	CDD:214550	88/324 (27%)
		PTPc	995..1220	CDD:238006	79/272 (29%)
PTP1	NP_010051.1	COG5599	1..335	CDD:227886	88/324 (27%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm46470
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.000