DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment IA-2 and PTPRN

DIOPT Version :9

Sequence 1:	NP_608562.4	Gene:	IA-2 / 33277	FlyBaseID:	FBgn0031294	Length:	1319	Species:	Drosophila melanogaster
Sequence 2:	NP_002837.1	Gene:	PTPRN / 5798	HGNCID:	9676	Length:	979	Species:	Homo sapiens

Alignment Length:	1191	Identity:	398/1191 - (33%)
Similarity:	522/1191 - (43%)	Gaps:	298/1191 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   124 RREVRGCGAGGGGLLCCSLDALSRPAKLLQFGVLLLILLLATHGDLAQAEGNVGCQFVRTLCIPH 188
            ||..|..|.||.|.|                .:||.:|||::......|....||.|.|.|| .|
Human     2 RRPRRPGGLGGSGGL----------------RLLLCLLLLSSRPGGCSAVSAHGCLFDRRLC-SH 49

  Fly   189 SEVCYDDNIFGKCIPTTGVDVEDIEKTPLTEDQSRVLATM---LEELQGAGLGWDHPYVQCRIQG 250
            .|||..|.:||:|....|      :..||.:..|.||..:   |.:|...||.|.....|..|.
Human    50 LEVCIQDGLFGQCQVGVG------QARPLLQVTSPVLQRLQGVLRQLMSQGLSWHDDLTQYVIS- 107

  Fly   251 SLFSLQRQQQLPPNLCANLAPTPPEFGDPASALAYVRFTPPEPEAELDYYEQPAGPAQFYPALRK 315
                 |..:::|     .|.|..|...| .|.||..|   |.|..||...:.|.|.|   ||.
Human   108 -----QEMERIP-----RLRPPEPRPRD-RSGLAPKR---PGPAGELLLQDIPTGSA---PAA-- 153

  Fly   316 KQVRESDADDMYLNRMLQDRRRLRHDPSELEHFGKMDGHGQSTQLD------APSIMDAFLDTER 374
                               :.||...|     .|| .|.|.|:.|.      .|.:::
Human   154 -------------------QHRLPQPP-----VGK-GGAGASSSLSPLQAELLPPLLE------- 186

  Fly   375 QRIEREQQLAAAEQDADRRAEQNRLELYQILAASEPDPQPYQRKPAAQPNAMDQLEAIVEQQQQR 439
                                       :.:|....|.|.........||....|..:       |
Human   187 ---------------------------HLLLPPQPPHPSLSYEPALLQPYLFHQFGS-------R 217

  Fly   440 ELKEQQEQAKAPVYVPPEEVNESSELYFPDNFAPFKRARGRSRGGLAEEVEDEQPKRSFFRELAG 504
            :.....|.:...|.|.|          .|...||...:|..|:|     :..:.|..| :.:|.|
Human   218 DGSRVSEGSPGMVSVGP----------LPKAEAPALFSRTASKG-----IFGDHPGHS-YGDLPG 266

  Fly   505 EQGLVQEPPLRFRHVETEVDATPELVKRRPASFKQLDPYDVSLQQQEMAFESGLLRNSLTPLEEE 569
            ..                           ||...|               :||||.     |.:|
Human   267 PS---------------------------PAQLFQ---------------DSGLLY-----LAQE 284

  Fly   570 AMLASNS----FPRQAKSQRV------YTEGGLLLMPQDEQDTDGMQADEPENVKQSLLANMLGF 624
            ....|.:    .|.|..|.|.      |.:.||    .|..:.....|.:|:...|.|.|.:.|:
Human   285 LPAPSRARVPRLPEQGSSSRAEDSPEGYEKEGL----GDRGEKPASPAVQPDAALQRLAAVLAGY 345

  Fly   625 ARHER--------------------------------LDVKK--PGPLLGPPSLGSAELSNQLET 655
            ....|                                .|:||  .||:.|   ..:|||..:...
Human   346 GVELRQLTPEQLSTLLTLLQLLPKGAGRNPGGVVNVGADIKKTMEGPVEG---RDTAELPARTSP 407

  Fly   656 EKAHKQKGHGNKEV--LPAHIKGNDEDDAH--------KKKKVMKQ-------QHSAEDHAPHTV 703
            ...|......:.||  :|:.:.......|.        :||..:.|       |.||...|
Human   408 MPGHPTASPTSSEVQQVPSPVSSEPPKAARPPVTPVLLEKKSPLGQSQPTVAGQPSARPAA---- 468

  Fly   704 DTEYVHVFVKNPIDSWNDGQRIMKELEQILHM-QGYFSYLTVQQHEVSFRVNSNNPERKTAGDVA 767
             .||.::.......|...|.::::.|.:.:|| .|.|..::|....::||:..|......|
Human   469 -EEYGYIVTDQKPLSLAAGVKLLEILAEHVHMSSGSFINISVVGPALTFRIRHNEQNLSLA---- 528

  Fly   768 RTINENRG-VKNNIQRRVGFYVLHAGVGDVIKDLQDPSVSSSRIELAEQGPDVTH-------IMA 824
             .:.:..| ||:.::.:.|..:|..|||             .|.|.|...|...|       ::.
Human   529 -DVTQQAGLVKSELEAQTGLQILQTGVG-------------QREEAAAVLPQTAHSTSPMRSVLL 579

  Fly   825 YMFAGAGAAAVIVIFVTLILIKRHDRKRDK--LGGLQSGIAGAETCSKDYQELCRARMAGKAGGG 887
            .:.|.||.|.::|.....:.:::|.|::||  |..|....|..:| :.:||:|||..||.|
Human   580 TLVALAGVAGLLVALAVALCVRQHARQQDKERLAALGPEGAHGDT-TFEYQDLCRQHMATK---- 639

  Fly   888 GNSTGGAAGGGSNEPAPSGRITSLSKENEG---RPPSSRSSTSSWSEEPALTNMDISTGHMVLSY 949
              |....|.|   .|.|| |::|:|.:...   ..|||.|||.||.||||..|||||||||:|:|
Human   640 --SLFNRAEG---PPEPS-RVSSVSSQFSDAAQASPSSHSSTPSWCEEPAQANMDISTGHMILAY 698

  Fly   950 MEDHLRNKGRLQREWEALCRYEAEPSAREAASQPQCAGLNRPGAPLPYDHSRVVLNHLANAEGLD 1014
            |||||||:.||.:||:|||.|:|||:....|........||....|||||:|:.|...::....|
Human   699 MEDHLRNRDRLAKEWQALCAYQAEPNTCATAQGEGNIKKNRHPDFLPYDHARIKLKVESSPSRSD 763

  Fly  1015 YVNASTITDHDPRAPAYVAAQGPLPSTLAHFWQMIWEQGAVVIVALCRLQENGEVACARYWPEEG 1079
            |:|||.|.:||||.|||:|.||||..|:|.||||:||.|..|||.|..|.|:|...|.||||:||
Human   764 YINASPIIEHDPRMPAYIATQGPLSHTIADFWQMVWESGCTVIVMLTPLVEDGVKQCDRYWPDEG 828

  Fly  1080 AEVYHIYEVHLVSEHIWCDDYLVRSFYLKNLRTSETRTVTQFHFLSWPHMGVPAQAKALLDFRRK 1144
            |.:||:|||:||||||||:|:|||||||||::|.||||:|||||||||..|.||..:.|||||||
Human   829 ASLYHVYEVNLVSEHIWCEDFLVRSFYLKNVQTQETRTLTQFHFLSWPAEGTPASTRPLLDFRRK 893

  Fly  1145 VNKSYRGRRSCPIVVHGSAGAGRTGVYILLDLVLERMNKGAREIDIAATLEHLRDQRAGVVATRQ 1209
            |||.||| |||||:||.|.||||||.|||:|:||.||.||.:||||||||||:||||.|:|.::.
Human   894 VNKCYRG-RSCPIIVHCSDGAGRTGTYILIDMVLNRMAKGVKEIDIAATLEHVRDQRPGLVRSKD 957

  Fly  1210 QFEFVLMAVAEEVHAILKALP 1230
            ||||.|.||||||:|||||||
Human   958 QFEFALTAVAEEVNAILKALP 978

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
IA-2	NP_608562.4	Receptor_IA-2	708..795	CDD:288410	19/88 (22%)
		PTPc	960..1220	CDD:214550	162/259 (63%)
		PTPc	995..1220	CDD:238006	149/224 (67%)
PTPRN	NP_002837.1	RESP18 homology domain	35..131		35/114 (31%)
		RESP18	60..138	CDD:291609	27/98 (28%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	112..173		26/99 (26%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	289..329		9/43 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	393..439		9/48 (19%)
		Sufficient for dimerization of proICA512. /evidence=ECO:0000269\|PubMed:25561468	449..575		32/148 (22%)
		Receptor_IA-2	472..557	CDD:288410	20/102 (20%)
		Sufficient for dimerization of proICA512. /evidence=ECO:0000250\|UniProtKB:P80560	601..732		67/141 (48%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	643..680		16/40 (40%)
		PTPc	709..968	CDD:214550	162/259 (63%)
		PTPc	736..968	CDD:238006	151/232 (65%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	330	1.000	Domainoid score	I1151
eggNOG	1	0.900	-	-		E2759_KOG0793
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	524	1.000	Inparanoid score	I1254
Isobase	1	0.950	-	0	Normalized mean entropy	S3974
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D281324at33208
OrthoFinder	1	1.000	-	-		FOG0002390
OrthoInspector	1	1.000	-	-		otm42253
orthoMCL	1	0.900	-	-		OOG6_105521
Panther	1	1.100	-	-	LDO	PTHR46106
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5067
SonicParanoid	1	1.000	-	-		X1583
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	14	13.810