Protein Alignment IA-2 and PTPRM

DIOPT Version :10

• Sequence 1: NP_608562.4
• Gene: IA-2 / 33277
• FlyBaseID: FBgn0031294
• Length: 1319
• Species: Drosophila melanogaster
• Sequence 2: XP_016881383.2
• Gene: PTPRM / 5797
• HGNCID: 9675
• Length: 1532
• Species: Homo sapiens
• Alignment Length: 474
• Identity: 131/474 - (27%)
• Similarity: 209/474 - (44%)
• Gaps: 91/474 - (19%)

  Fly   814 EQGPDVTHIMAYMFAGAGAAAVIVIFVTLILIKRHDRKRDKLGGLQSGIAGAETCSKDYQE---L 875
            |:..|.|..:|.:.||.....:|.:.|.|::.||...|:.|           ||.|...||   :
Human   784 EKQTDHTVKIAGVIAGILLFVIIFLGVVLVMKKRKLAKKRK-----------ETMSSTRQEMTVM 837

  Fly   876 CRARMAGKAGGGGN--------STGGAAGGGSNEPA-----------------------PSGRIT 909
            ..:.....|..|.|        .|....|...:.|:                       |:..:.
Human   838 VNSMDKSYAEQGTNCDEAFSFMDTHNLNGRSVSSPSSFTMKTNTLSTSVPNSYYPDPFVPTAILV 902

  Fly   910 SLSKENEGRPPSSRSSTSSW-------SEEPALTNMDISTGHM--------VLSYMEDHLRNKG- 958
            .::.|..    :..|.|||.       ..|||  ::...||.:        :|.::......:|
Human   903 PINDETH----TMASDTSSLVQSHTYKKREPA--DVPYQTGQLHPAIRVADLLQHITQMKCAEGY 961

  Fly   959 RLQREWEALCRYEAEPSAREAASQPQCAGLNRPGAPLPYDHSRVVLNHLANAEGLDYVNASTITD 1023
            ..:.|:|:.  :|.:.:..::|.:.:....||.|..:.||||||.|..:......||:|.:.| |
Human   962 GFKEEYESF--FEGQSAPWDSAKKDENRMKNRYGNIIAYDHSRVRLQTIEGDTNSDYINGNYI-D 1023

  Fly  1024 HDPRAPAYVAAQGPLPSTLAHFWQMIWEQGAVVIVALCRLQENGEVACARYWPEEGAEVYHIYEV 1088
            ...|...|:|.|||:..|:..||:|:|.:....|:.:..|.|.|.|.|.:|||:: .|:|...:|
Human  1024 GYHRPNHYIATQGPMQETIYDFWRMVWHENTASIIMVTNLVEVGRVKCCKYWPDD-TEIYKDIKV 1087

  Fly  1089 HLVSEHIWCDDYLVRSFYLK--------NLRTS---------ETRTVTQFHFLSWPHMGVPAQAK 1136
            .|:...:.. :|::|:|.::        |...|         |.|.:.||||..||..|||..|.
Human  1088 TLIETELLA-EYVIRTFAVEKGGAGGEANCSPSREVSQRGVHEIREIRQFHFTGWPDHGVPYHAT 1151

  Fly  1137 ALLDFRRKVNKSYRGRRSCPIVVHGSAGAGRTGVYILLDLVLERMNKGAREIDIAATLEHLRDQR 1201
            .||.|.|:| ||.....:.|:|||.||||||||.:|::|::|: |.:....:||...:..||.:|
Human  1152 GLLGFVRQV-KSKSPPSAGPLVVHCSAGAGRTGCFIVIDIMLD-MAEREGVVDIYNCVRELRSRR 1214

  Fly  1202 AGVVATRQQFEFVLMAVAE 1220
            ..:|.|.:|:.|:..|:.|
Human  1215 VNMVQTEEQYVFIHDAILE 1233

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
IA-2	NP_608562.4	Receptor_IA-2	705..795	CDD:463293
		PTP_DSP_cys	942..1225	CDD:475123	98/305 (32%)
PTPRM	XP_016881383.2	MAM	50..207	CDD:214533
		FN3	180..>663	CDD:442628
		ig	217..299	CDD:395002
		fn3	524..599	CDD:394996
		R-PTPc-M-1	947..1236	CDD:350481	96/294 (33%)
		R-PTPc-M-2	1322..1527	CDD:350483