Protein Alignment IA-2 and PTPRK

DIOPT Version :10

• Sequence 1: NP_608562.4
• Gene: IA-2 / 33277
• FlyBaseID: FBgn0031294
• Length: 1319
• Species: Drosophila melanogaster
• Sequence 2: NP_001278910.1
• Gene: PTPRK / 5796
• HGNCID: 9674
• Length: 1462
• Species: Homo sapiens
• Alignment Length: 502
• Identity: 147/502 - (29%)
• Similarity: 228/502 - (45%)
• Gaps: 74/502 - (14%)

  Fly   769 TINENR---GVKN-NIQRRVGFYVLHAGVGDVIKDLQDPSV----SSSRIELAEQGPDVTHIMAY 825
            |:.:||   |..| .:..|.|:.:....:..|.|:.:...|    .::..|..|..||.......
Human   686 TVGDNRTYQGFWNPPLAPRKGYNIYFQAMSSVEKETKTQCVRIATKAAATEEPEVIPDPAKQTDR 750

  Fly   826 MFAGAGAAAVIVIFVTLILI--------KRHDRKRDKLGGLQSGIAGAETCSKDYQELCRARMAG 882
            :...||.:|.|::|:.|:|:        |...:::|.:|..:             ||:.....|.
Human   751 VVKIAGISAGILVFILLLLVVILIVKKSKLAKKRKDAMGNTR-------------QEMTHMVNAM 802

  Fly   883 KAGGGGNSTGGAAGGGS--------------NEP-APSGRITSLSKENEGRPPSS---------- 922
            .......||..|....|              |:| .|:..:..::.||......|
Human   803 DRSYADQSTLHAEDPLSITFMDQHNFSPRLPNDPLVPTAVLVPITDENHSATAESSRLLDVPRYL 867

  Fly   923 ----RSSTSSWSEEPALTNMDISTGHMVLSYMEDHLRNKGRLQREWEALCRYEAEPSAREAASQP 983
                .|...:....||:...|: ..|:.|....|....|    .|:|:.  :|.:.::.:.|.:.
Human   868 CEGTESPYQTGQLHPAIRVADL-LQHINLMKTSDSYGFK----EEYESF--FEGQSASWDVAKKD 925

  Fly   984 QCAGLNRPGAPLPYDHSRVVLNHLANAEGLDYVNASTI-----TDHDPRAPAYVAAQGPLPSTLA 1043
            |....||.|..:.||||||:|..:.:....||:||:.|     .|...|...|:|.|||:..|:.
Human   926 QNRAKNRYGNIIAYDHSRVILQPVEDDPSSDYINANYIDIWLYRDGYQRPSHYIATQGPVHETVY 990

  Fly  1044 HFWQMIWEQGAVVIVALCRLQENGEVACARYWPEEGAEVYHIYEVHLVSEHIWCDDYLVRSFYLK 1108
            .||:|||::.:..||.:..|.|.|.|.|.:|||:: .|||..::|..| |.....:|:||:|.|:
Human   991 DFWRMIWQEQSACIVMVTNLVEVGRVKCYKYWPDD-TEVYGDFKVTCV-EMEPLAEYVVRTFTLE 1053

  Fly  1109 NLRTSETRTVTQFHFLSWPHMGVPAQAKALLDFRRKVNKSYRGRRSCPIVVHGSAGAGRTGVYIL 1173
            ....:|.|.|.||||..||..|||..|..||.|.|:|..| ....:.|||||.||||||||.||:
Human  1054 RRGYNEIREVKQFHFTGWPDHGVPYHATGLLSFIRRVKLS-NPPSAGPIVVHCSAGAGRTGCYIV 1117

  Fly  1174 LDLVLERMNKGAREIDIAATLEHLRDQRAGVVATRQQFEFVLMAVAE 1220
            :|::|: |.:....:||...::.||.:|..:|.|.:|:.|:..|:.|
Human  1118 IDIMLD-MAEREGVVDIYNCVKALRSRRINMVQTEEQYIFIHDAILE 1163

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
IA-2	NP_608562.4	Receptor_IA-2	705..795	CDD:463293	7/29 (24%)
		PTP_DSP_cys	942..1225	CDD:475123	106/284 (37%)
PTPRK	NP_001278910.1	MAM	32..192	CDD:214533
		IG_like	202..288	CDD:214653
		Ig strand B	212..216	CDD:409353
		Ig strand C	226..232	CDD:409353
		Ig strand E	253..257	CDD:409353
		Ig strand F	267..272	CDD:409353
		fn3	294..371	CDD:394996
		fn3	488..583	CDD:394996
		PTP_DSP_cys	888..1166	CDD:475123	107/287 (37%)
		R-PTPc-K-2	1252..1457	CDD:350484