DRSC/TRiP Functional Genomics Resources

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Protein Alignment IA-2 and PTPRF

DIOPT Version :10

Sequence 1:NP_608562.4 Gene:IA-2 / 33277 FlyBaseID:FBgn0031294 Length:1319 Species:Drosophila melanogaster
Sequence 2:XP_005271136.1 Gene:PTPRF / 5792 HGNCID:9670 Length:1922 Species:Homo sapiens


Alignment Length:894 Identity:222/894 - (24%)
Similarity:345/894 - (38%) Gaps:238/894 - (26%)


- Green bases have known domain annotations that are detailed below.


  Fly   476 RARGRSRGGLAEEVEDE----QPKRSFFRELAGEQGLVQ-------EPP---------LRFRHVE 520
            |...::|.||.||.|.|    :...|.|.:.....||..       :||         :.:..|.
Human   895 RLAAKNRAGLGEEFEKEIRTPEDLPSGFPQNLHVTGLTTSTTELAWDPPVLAERNGRIISYTVVF 959

  Fly   521 TEVDATPEL---------------------VKRRPASFKQLDPYDVSLQQQEMAFESGLLRN-SL 563
            .::::..||                     :|.|..:.|...|...|:|.:.|..|....:| .:
Human   960 RDINSQQELQNITTDTRFTLTGLKPDTTYDIKVRAWTSKGSGPLSPSIQSRTMPVEQVFAKNFRV 1024

  Fly   564 TPLEEEAMLASNSFPRQAKSQRVYTEGGLLLMPQDEQDTDG-----MQADEPENVKQSLL----A 619
            ....:.::|.|...|...||...:.    :|......:.||     :.||...|.:.|.:    .
Human  1025 AAAMKTSVLLSWEVPDSYKSAVPFK----ILYNGQSVEVDGHSMRKLIADLQPNTEYSFVLMNRG 1085

  Fly   620 NMLGFARHERLDVKKPGPLLGPPSLGSAELSNQLETEKAHKQKGHGNKEVLP--AHIKGNDEDDA 682
            :..|..:|  |...:..|.|.|                 ||.        ||  |:|:....|.:
Human  1086 SSAGGLQH--LVSIRTAPDLLP-----------------HKP--------LPASAYIEDGRFDLS 1123

  Fly   683 HKKKKVMKQQHSAEDHAPHTVDTEYVHVF--VKNPID---------SWNDGQRIMKELEQILHM- 735
                            .||..|...|..|  |..|||         .|:..:.:  ||:::|.. 
Human  1124 ----------------MPHVQDPSLVRWFYIVVVPIDRVGGSMLTPRWSTPEEL--ELDELLEAI 1170

  Fly   736 -QG-------------YFSYLTVQQHEVSFRVNSNNPERKTAGDVARTINENRGVKNNIQRRVGF 786
             ||             ...|:..|...:        ||..|.||           |.|.:   ||
Human  1171 EQGGEEQRRRRRQAERLKPYVAAQLDVL--------PETFTLGD-----------KKNYR---GF 1213

  Fly   787 Y--VLHAGVG---DVIKDLQDP--------SVSSSRIEL------AEQGPDVTHIMAYMFAGAGA 832
            |  .|...:.   .|:..|::|        |..|..|.:      .::.|::      ::.....
Human  1214 YNRPLSPDLSYQCFVLASLKEPMDQKRYASSPYSDEIVVQVTPAQQQEEPEM------LWVTGPV 1272

  Fly   833 AAVIVIFVTLILIKRHDRKRDKLGGLQSGIAGAETCSKDYQELCRARMAGKAGGGGNSTGGAAGG 897
            .|||:|.:.:|.|....|||..           ...|||.|.:              ....:...
Human  1273 LAVILIILIVIAILLFKRKRTH-----------SPSSKDEQSI--------------GLKDSLLA 1312

  Fly   898 GSNEPAPSGRITSLSKENEGRPPSSRSSTSSWSEEPALTNMDISTGHMVLSYMEDHLRNKG-RLQ 961
            .|::|....|   |:.:..|....|..:|||..:.|.:...|::..      :|....|.| :..
Human  1313 HSSDPVEMRR---LNYQTPGSSVPSCPNTSSMRDHPPIPITDLADN------IERLKANDGLKFS 1368

  Fly   962 REWEAL---CRYEAEPSAREAASQPQCAGLNRPGAPLPYDHSRVVLNHLANAEGLDYVNASTITD 1023
            :|:|::   .::..|.|..| .::|:    ||....:.||||||:|..:....|.||:||:.| |
Human  1369 QEYESIDPGQQFTWENSNLE-VNKPK----NRYANVIAYDHSRVILTSIDGVPGSDYINANYI-D 1427

  Fly  1024 HDPRAPAYVAAQGPLPSTLAHFWQMIWEQGAVVIVALCRLQENGEVACARYWPEEGAEVYHIYEV 1088
            ...:..||:|.|||||.|:..||:|:|||....:|.:.||:|...|.|.:|||..|.|...:.:|
Human  1428 GYRKQNAYIATQGPLPETMGDFWRMVWEQRTATVVMMTRLEEKSRVKCDQYWPARGTETCGLIQV 1492

  Fly  1089 HLVSEHIWCDDYLVRSFYLKNLRTSETRTVTQFHFLSWPHMGVPAQAKALLDFRRKVNKSYRGRR 1153
            .|: :.:....|.||:|.|....:||.|.:.||.|::||..|||.....:|.|.|:|       :
Human  1493 TLL-DTVELATYTVRTFALHKSGSSEKRELRQFQFMAWPDHGVPEYPTPILAFLRRV-------K 1549

  Fly  1154 SC------PIVVHGSAGAGRTGVYILLDLVLERMNKGAREIDIAATLEHLRDQRAGVVATRQQFE 1212
            :|      |:|||.|||.||||.:|::|.:|||| |..:.:||...:..:|.||..:|.|..|:.
Human  1550 ACNPLDAGPMVVHCSAGVGRTGCFIVIDAMLERM-KHEKTVDIYGHVTCMRSQRNYMVQTEDQYV 1613

  Fly  1213 FVLMAVAEEVHAILKALPA-NTSGEKRELDKDPVVGGGSSSTTTKEPLK 1260
            |:..|:.|........:|| |.....::|.:.|   .|.|.|..:...|
Human  1614 FIHEALLEAATCGHTEVPARNLYAHIQKLGQVP---PGESVTAMELEFK 1659

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
IA-2NP_608562.4 Receptor_IA-2 705..795 CDD:463293 25/120 (21%)
PTP_DSP_cys 942..1225 CDD:475123 103/292 (35%)
PTPRFXP_005271136.1 I-set 33..124 CDD:400151
Ig strand B 50..54 CDD:409353
Ig strand C 63..67 CDD:409353
Ig strand E 86..93 CDD:409353
Ig strand F 104..109 CDD:409353
Ig strand G 117..120 CDD:409353
IgI_2_RPTP_IIa_LAR_like 136..226 CDD:409400
Ig strand A 136..138 CDD:409400
Ig strand A' 143..147 CDD:409400
Ig strand B 150..159 CDD:409400
Ig strand C 164..170 CDD:409400
Ig strand C' 172..174 CDD:409400
Ig strand D 183..187 CDD:409400
Ig strand E 190..195 CDD:409400
Ig strand F 204..211 CDD:409400
Ig strand G 214..225 CDD:409400
IgI_3_RPTP_IIa_LAR_like 239..320 CDD:409401
Ig strand A 239..241 CDD:409401
Ig strand A' 245..249 CDD:409401
Ig strand B 252..260 CDD:409401
Ig strand C 265..271 CDD:409401
Ig strand C' 273..275 CDD:409401
Ig strand D 278..282 CDD:409401
Ig strand E 287..292 CDD:409401
Ig strand F 299..306 CDD:409401
Ig strand G 310..319 CDD:409401
FN3 <311..716 CDD:442628
FN3 714..820 CDD:238020
FN3 825..914 CDD:238020 8/18 (44%)
FN3 923..1011 CDD:238020 13/87 (15%)
FN3 1020..>1079 CDD:238020 12/62 (19%)
R-PTPc-F-1 1350..1625 CDD:350474 104/295 (35%)
R-PTP-F-2 1627..1917 CDD:350477 9/36 (25%)
Blue background indicates that the domain is not in the aligned region.

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