DRSC/TRiP Functional Genomics Resources

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Protein Alignment IA-2 and PTPRB

DIOPT Version :10

Sequence 1:NP_608562.4 Gene:IA-2 / 33277 FlyBaseID:FBgn0031294 Length:1319 Species:Drosophila melanogaster
Sequence 2:XP_006719591.1 Gene:PTPRB / 5787 HGNCID:9665 Length:2230 Species:Homo sapiens


Alignment Length:856 Identity:189/856 - (22%)
Similarity:312/856 - (36%) Gaps:259/856 - (30%)


- Green bases have known domain annotations that are detailed below.


  Fly   455 PPE--EVNESSELYFPDN----FAPF--KRARGRSRGGLAEEVEDEQPKRSF---FRELAGEQGL 508
            ||:  :.|:....:.|.:    |.|:  :::.||...||       :|.||:   .:.::|:...
Human  1502 PPDWTDYNDFELQWLPRDALTVFNPYNNRKSEGRIVYGL-------RPGRSYQFNVKTVSGDSWK 1559

  Fly   509 VQEPPLRFRHVETEVDATPELVKRRPASF----------KQLDPYDV---SLQQQEMAFESGLLR 560
            ....|: |..|.|:.|....|..|...|.          ...|.|.:   .:..||:.|.     
Human  1560 TYSKPI-FGSVRTKPDKIQNLHCRPQNSTAIACSWIPPDSDFDGYSIECRKMDTQEVEFS----- 1618

  Fly   561 NSLTPLEEEAMLASNSFPRQAKSQRVYTEGGLLLMPQD------EQDTDGMQADEPENVKQSLLA 619
               ..||:|..|.:.                ::|:|..      :..:.||.::..|:...::  
Human  1619 ---RKLEKEKSLLNI----------------MMLVPHKRYLVSIKVQSAGMTSEVVEDSTITM-- 1662

  Fly   620 NMLGFARHERLDVKKPGPLLGPPSLGSAELSNQLETEKAHKQKGHGNKEVLPAHIKGNDEDDAHK 684
                        :.:|     ||.                           |.||:.|::|....
Human  1663 ------------IDRP-----PPP---------------------------PPHIRVNEKDVLIS 1683

  Fly   685 KKKVMKQQHSAEDHAPHTV------DT----EYVHVFVKNPIDSWNDGQRIMKELEQILHMQGYF 739
            |..:           ..||      ||    :|..|.|:..     ||...:|. ||...:..|.
Human  1684 KSSI-----------NFTVNCSWFSDTNGAVKYFTVVVREA-----DGSDELKP-EQQHPLPSYL 1731

  Fly   740 SYLTVQQHEVSFRV--------------NSNN--------PERKTAGDVARTINE---NRGVKNN 779
            .|    :|..|.||              |||:        .|.::.|.......:   :..:|.:
Human  1732 EY----RHNASIRVYQTNYFASKCAENPNSNSKSFNIKLGAEMESLGGKCDPTQQKFCDGPLKPH 1792

  Fly   780 IQRRVGFYVLHAGVGDVIKDLQDPSVSSSRIELAEQGPDVTHIMAYMFAGAGAAA------VIVI 838
            ...|:..........:.:|:...|..|.:...|    |..|.......|..|.:|      ::|.
Human  1793 TAYRISIRAFTQLFDEDLKEFTKPLYSDTFFSL----PITTESEPLFGAIEGVSAGLFLIGMLVA 1853

  Fly   839 FVTLILIKR---HDRKRDKLGGLQSGIAGAETCSKDYQELCRARMAGKAGGGGNSTGGAAGGGSN 900
            .|.|::.::   |.|:|                                                
Human  1854 VVALLICRQKVSHGRER------------------------------------------------ 1870

  Fly   901 EPAPSGRITSLSKE-------NEGRPPSSRSSTSSWSEEPALTNMDISTGH-MVLSYMEDHLRNK 957
               ||.|: |:.::       |.|:..:.::|.      |...|.  ..|| |.|....::|   
Human  1871 ---PSARL-SIRRDRPLSVHLNLGQKGNRKTSC------PIKINQ--FEGHFMKLQADSNYL--- 1920

  Fly   958 GRLQREWEALCRYEAEPSAREAASQPQCAGLNRPGAPLPYDHSRVVLNHLANAEGLDYVNASTIT 1022
              |.:|:|.|.......|. :.|..|:..|.||....||||.:||.|:::.:....||:|||.|.
Human  1921 --LSKEYEELKDVGRNQSC-DIALLPENRGKNRYNNILPYDATRVKLSNVDDDPCSDYINASYIP 1982

  Fly  1023 DHDPRAPAYVAAQGPLPSTLAHFWQMIWEQGAVVIVALCRLQENGEVACARYWPEEGAEVYH-IY 1086
            .::.|. .|:..|||||.|...||:|:|||....||.:.:..|.|.|.|..|||.:...:|: ..
Human  1983 GNNFRR-EYIVTQGPLPGTKDDFWKMVWEQNVHNIVMVTQCVEKGRVKCDHYWPADQDSLYYGDL 2046

  Fly  1087 EVHLVSEHIWCDDYLVRSFYLKNLRTSET-RTVTQFHFLSWPHMGVPAQAKALLDFRRKVNKSY- 1149
            .:.::||.: ..::.:|.|.:......:. |.:..||:..||..|||...::|:.|.|.| :.| 
Human  2047 ILQMLSESV-LPEWTIREFKICGEEQLDAHRLIRHFHYTVWPDHGVPETTQSLIQFVRTV-RDYI 2109

  Fly  1150 -RGRRSCPIVVHGSAGAGRTGVYILLDLVLERMNKGAREIDIAATLEHLRDQRAGVVATRQQFEF 1213
             |...:.|.|||.|||.||||.:|.||.:|:::: ....:||...:..||..|..:|.|..|:.:
Human  2110 NRSPGAGPTVVHCSAGVGRTGTFIALDRILQQLD-SKDSVDIYGAVHDLRLHRVHMVQTECQYVY 2173

  Fly  1214 VLMAVAEEVHA 1224
            :...|.:.:.|
Human  2174 LHQCVRDVLRA 2184

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
IA-2NP_608562.4 Receptor_IA-2 705..795 CDD:463293 22/118 (19%)
PTP_DSP_cys 942..1225 CDD:475123 95/288 (33%)
PTPRBXP_006719591.1 beta-trefoil_Ricin_PTPRB-like 18..134 CDD:467787
fn3 255..316 CDD:394996
fn3 331..407 CDD:394996
FN3 422..488 CDD:473895
FN3 507..582 CDD:238020
fn3 596..672 CDD:394996
fn3 687..765 CDD:394996
fn3 774..847 CDD:394996
fn3 862..938 CDD:394996
fn3 950..1026 CDD:394996
fn3 1039..1112 CDD:394996
FN3 1093..1508 CDD:442628 2/5 (40%)
fn3 1126..1199 CDD:394996
fn3 1393..1466 CDD:394996
fn3 1480..1562 CDD:394996 14/66 (21%)
fn3 1574..1653 CDD:394996 17/102 (17%)
PTP_tm 1691..1828 CDD:465889 29/150 (19%)
R-PTPc-B 1949..2176 CDD:350465 80/230 (35%)
Blue background indicates that the domain is not in the aligned region.

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