Protein Alignment IA-2 and PTPRA

DIOPT Version :10

• Sequence 1: NP_608562.4
• Gene: IA-2 / 33277
• FlyBaseID: FBgn0031294
• Length: 1319
• Species: Drosophila melanogaster
• Sequence 2: NP_001372231.1
• Gene: PTPRA / 5786
• HGNCID: 9664
• Length: 813
• Species: Homo sapiens
• Alignment Length: 827
• Identity: 194/827 - (23%)
• Similarity: 319/827 - (38%)
• Gaps: 210/827 - (25%)

  Fly   456 PEEVNESSELYFPDNFAPFKRARGRSRGGLAEEVEDEQPKRSFFRELAG---------------- 504
            |.|.|.|:....|:.|.|...:..:.|       .||.|..:....|:.
Human   131 PWEGNSSTAATTPETFPPSGNSDSKDR-------RDETPIIAVMVALSSLLVIVFIIIVLYMLRF 188

  Fly   505 ---EQGLVQEPPLRFRHVETEVDATPE---LVKRRPASFKQLDPYDVSLQQQE----MAFESGLL 559
               :|........|..:..|| |..|:   |:.|.|::.::..|..|...::|    ||.::.|.
Human   189 KKYKQAGSHSNSFRLSNGRTE-DVEPQSVPLLARSPSTNRKYPPLPVDKLEEEINRRMADDNKLF 252

  Fly   560 RNSLTPLEEEAMLASNSFPRQAKSQRVYTEGGLLLMPQDEQDTDGMQADEPENVKQSLLANMLGF 624
            |.....|.        :.|.||..:                     .|.:.||.:::...|:|.:
Human   253 REEFNALP--------ACPIQATCE---------------------AASKEENKEKNRYVNILPY 288

  Fly   625 ARHERLDVKKPGPLLGPPSLGSAELSNQLETE--KAHKQKGHGNKEVLPAHIKGNDEDDAHKKKK 687
             .|.|:.:.   |:.|.|.      |:.:...  ..:::|   ||.:.   .:|..|:..:...:
Human   289 -DHSRVHLT---PVEGVPD------SDYINASFINGYQEK---NKFIA---AQGPKEETVNDFWR 337

  Fly   688 VMKQQHSAEDHAPHTVDTEYVHVFVKNPIDSWNDGQRIMKELE-----QILHMQGYFSY--LTVQ 745
            ::.:|::|      |:      |.|.|           :||.:     |....||.::|  :.|.
Human   338 MIWEQNTA------TI------VMVTN-----------LKERKECKCAQYWPDQGCWTYGNIRVS 379

  Fly   746 QHEVSFRVNSNNPERK----TAGDVARTINENRGVKNNIQRRVGFYVLHAGVGDVIKDLQDPSVS 806
            ..:|:..|:..  .||    ..||:.....:....:.:......|.|....:| ::|.|:.....
Human   380 VEDVTVLVDYT--VRKFCIQQVGDMTNRKPQRLITQFHFTSWPDFGVPFTPIG-MLKFLKKVKAC 441

  Fly   807 SSRIELAEQGPDVTHIMAYMFAGAGAAAVIVIFVTLILIKRHDRKRDKLGGLQSGIAGAETCSK- 870
            :.:...|        |:.:..||.|.....|:...::.:...:||.| :.|..|.|. |:.|..
Human   442 NPQYAGA--------IVVHCSAGVGRTGTFVVIDAMLDMMHTERKVD-VYGFVSRIR-AQRCQMV 496

  Fly   871 --------DYQELCRARMAGKAGGGGNSTGGAAGGGSNEPAPSGRITSLSKENEGRPPSSRSSTS 927
                    .||.|....:.|.
Human   497 QTDMQYVFIYQALLEHYLYGD-------------------------------------------- 517

  Fly   928 SWSEEPALTNMDISTGHMVLSYMEDHLR----------NKGRLQREWEALCRYEAEPSAREAASQ 982
                    |.:::::       :|.||:          |.| |:.|::.|...:.:.......:.
Human   518 --------TELEVTS-------LETHLQKIYNKIPGTSNNG-LEEEFKKLTSIKIQNDKMRTGNL 566

  Fly   983 PQCAGLNRPGAPLPYDHSRVVLNHLANAEGLDYVNASTITDHDPRAPAYVAAQGPLPSTLAHFWQ 1047
            |.....||....:||:.:||::......|..||||||.| |...:..:|:|:||||..|:..||:
Human   567 PANMKKNRVLQIIPYEFNRVIIPVKRGEENTDYVNASFI-DGYRQKDSYIASQGPLLHTIEDFWR 630

  Fly  1048 MIWEQGAVVIVALCRLQENGEVACARYWPEEGAEVYHIYEVHLVSEHIWCDDYLVRSFYLKNLRT 1112
            ||||..:..||.|..|:|.|:..||:|||.:|...|....|.|..|. .|:.|.||...:.|.|.
Human   631 MIWEWKSCSIVMLTELEERGQEKCAQYWPSDGLVSYGDITVELKKEE-ECESYTVRDLLVTNTRE 694

  Fly  1113 SETRTVTQFHFLSWPHMGVPAQAKALLDFRRKVNKSYRGRRSCPIVVHGSAGAGRTGVYILLDLV 1177
            :::|.:.||||..||.:|:|:..|.::.....|.|..:...:.||.||.||||||||.:..|..|
Human   695 NKSRQIRQFHFHGWPEVGIPSDGKGMISIIAAVQKQQQQSGNHPITVHCSAGAGRTGTFCALSTV 759

  Fly  1178 LERMNKGAREIDIAATLEHLRDQRAGVVATRQQFEFVLMAVAEEVHA 1224
            |||: |....:|:..|::.||.||..:|.|.:|:||....|.|.:.|
Human   760 LERV-KAEGILDVFQTVKSLRLQRPHMVQTLEQYEFCYKVVQEYIDA 805

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
IA-2	NP_608562.4	Receptor_IA-2	705..795	CDD:463293	18/100 (18%)
		PTP_DSP_cys	942..1225	CDD:475123	103/293 (35%)
PTPRA	NP_001372231.1	R-PTPc-A-1	225..520	CDD:350469	70/427 (16%)
		R-PTPc-A-2	574..801	CDD:350471	91/229 (40%)