Protein Alignment IA-2 and PTPN13

DIOPT Version :10

• Sequence 1: NP_608562.4
• Gene: IA-2 / 33277
• FlyBaseID: FBgn0031294
• Length: 1319
• Species: Drosophila melanogaster
• Sequence 2: XP_011530467.1
• Gene: PTPN13 / 5783
• HGNCID: 9646
• Length: 2507
• Species: Homo sapiens
• Alignment Length: 1269
• Identity: 260/1269 - (20%)
• Similarity: 419/1269 - (33%)
• Gaps: 415/1269 - (32%)

  Fly   164 ATHGDLAQAEGNVGCQFVRTLC-----------IPHSEVC--YDDNIFGKCIPTTGVDVEDIEKT 215
            |||....:...|.| |.|..|.           :|.:..|  .|.|       ..|...|.::||
Human  1434 ATHKQAVETLRNTG-QVVHLLLEKGQSPTSKEHVPVTPQCTLSDQN-------AQGQGPEKVKKT 1490

  Fly   216 PLTEDQSRVLATMLEELQ----GAGLGWDHPYVQCRIQGSLFSLQRQQQL-PPNLCANLAPTPPE 275
            ...:|.|.|......|::    .:|||              ||..|:..| |..:.|::......
Human  1491 TQVKDYSFVTEENTFEVKLFKNSSGLG--------------FSFSREDNLIPEQINASIVRVKKL 1541

  Fly   276 F-GDPAS--------------------------ALAYVRFTPPE-------------PEAELDYY 300
            | |.||:                          .::.:|.|.||             ||.:....
Human  1542 FPGQPAAESGKIDVGDVILKVNGASLKGLSQQEVISALRGTAPEVFLLLCRPPPGVLPEIDTALL 1606

  Fly   301 EQPAGPAQFYPALRKKQ-----VRESDADDMYLNRMLQDRRRLRHDPSELEHFGKMDGHGQSTQL 360
            .....|||..|...|..     |.:|.:.|.  |.|....::....||..:.:....|.|:...:
Human  1607 TPLQSPAQVLPNSSKDSSQPSCVEQSTSSDE--NEMSDKSKKQCKSPSRRDSYSDSSGSGEDDLV 1669

  Fly   361 DAPSIM--DAFLDTERQRIEREQQLAAAEQDADRRAEQNRLELYQI---------LAASEPDPQP 414
            .||:.:  ..:.....|.:......|.:..:|.:..|.....::..         ...|.|.|.|
Human  1670 TAPANISNSTWSSALHQTLSNMVSQAQSHHEAPKSQEDTICTMFYYPQKIPNKPEFEDSNPSPLP 1734

  Fly   415 YQRKP--AAQPNAMDQLEAIVEQQQQRELKEQQEQAKAPVYVPPEEVNESSELYFPDNFAPFKRA 477
            ....|  :.||.:.....:.:::.....:.|...|                     :|:.|.|
Human  1735 PDMAPGQSYQPQSESASSSSMDKYHIHHISEPTRQ---------------------ENWTPLK-- 1776

  Fly   478 RGRSRGGLAEEVED------------EQPKRSF-FRELAGEQ-------GLVQEPP--------- 513
                 ..|...:||            :..|.|. |....|.|       .::|:|.
Human  1777 -----NDLENHLEDFELEVELLITLIKSEKGSLGFTVTKGNQRIGCYVHDVIQDPAKSDGRLKPG 1836

  Fly   514 ---LRFRHVE----TEVDA---------TPELVKRRPASFKQLD--PY---DVSL--QQQEMAFE 555
               ::....:    |..||         |..||..|.....::.  |:   |::|  .::|:.|.
Human  1837 DRLIKVNDTDVTNMTHTDAVNLLRAASKTVRLVIGRVLELPRIPMLPHLLPDITLTCNKEELGFS 1901

  Fly   556 SGLLRNSLTPLEEEAMLASNSFPRQAKSQRVYTEGGLLLMP----QDEQDTDGMQADEPEN-VKQ 615
            .....:||    .:.:..|:..||...:    .||.|.|:.    .:...|.||..:|... :..
Human  1902 LCGGHDSL----YQVVYISDINPRSVAA----IEGNLQLLDVIHYVNGVSTQGMTLEEVNRALDM 1958

  Fly   616 SLLANMLGFARHE--------RLDVKKP---------------GPLLGPP---SLGSAELSNQLE 654
            ||.:.:|...|::        |..|..|               .|.|.|.   |..:.|..|::.
Human  1959 SLPSLVLKATRNDLPVVPSSKRSAVSAPKSTKGNGSYSVGSCSQPALTPNDSFSTVAGEEINEIS 2023

  Fly   655 TEK----AHKQKGHGNKEVLPAHIKGN--DEDDAHKKKKVMKQQHSAEDHAPHTVDTEYVHVFVK 713
            ..|    .::.||..|. .||   ||:  ::...:.|.....:.:..||
Human  2024 YPKGKCSTYQIKGSPNL-TLP---KGSFPNQSSNYSKCPNNSESYIQED---------------- 2068

  Fly   714 NPIDSWNDGQRIMKELEQILHMQGYFSYLTVQQHEVSFRVNSNNPERKTAGDVARTINENRGVKN 778
               |.::|.|    |.|.|.      |.|.|...|....:|.||....:.|.....:|
Human  2069 ---DIYDDSQ----EAEVIQ------SLLDVVDEEAQNLLNENNAAGYSCGPGTLKMN------- 2113

  Fly   779 NIQRRVGFYVLHAGVGDVIKDLQDPSVSSSRIELAEQGPDVTHIMAYMFAGAGAAAVIVIFVTLI 843
                                    ..:|..|.|  :...|.:.:..|.
Human  2114 ------------------------GKLSEERTE--DTDCDGSPLPEYF----------------- 2135

  Fly   844 LIKRHDRKRDKLGGLQSGIAGAETCSKDYQELCRARMAGKAGGGGNSTGGAAGGGSNEPAPSGRI 908
                  .:..|:.|          |    :|.|..::..:               |....|..:.
Human  2136 ------TEATKMNG----------C----EEYCEEKVKSE---------------SLIQKPQEKK 2165

  Fly   909 T---SLSKENEGRPPSSRSSTSSWSEEPALTNMDIS-------------TGHMVLSYME--DHLR 955
            |   .::..|:..|....:...|..:...|||.:::             ||..:.|.:.  ..|.
Human  2166 TDDDEITWGNDELPIERTNHEDSDKDHSFLTNDELAVLPVVKVLPSGKYTGANLKSVIRVLRGLL 2230

  Fly   956 NKGRLQREWEALCRYEAEPSAREAASQPQC--------AGLNRPGAPLPYDHSRVVLNHLANAEG 1012
            ::|...:|.|.|         :|.....||        ...||....||||.:||.|..    ||
Human  2231 DQGIPSKELENL---------QELKPLDQCLIGQTKENRRKNRYKNILPYDATRVPLGD----EG 2282

  Fly  1013 LDYVNASTITDHDPRAP------AYVAAQGPLPSTLAHFWQMIWEQGAVVIVALCRLQENGEVAC 1071
             .|:|||.|     :.|      .|:|.|||||:|:..||||||||.:.||..:.:..|..::.|
Human  2283 -GYINASFI-----KIPVGKEEFVYIACQGPLPTTVGDFWQMIWEQKSTVIAMMTQEVEGEKIKC 2341

  Fly  1072 ARYWPEEGAEVYHIYEVHLVSEHI--------WCDDYLVRSFYLKNLRTSETRTVTQFHFLSWPH 1128
            .||||.      .:.:..:||..:        ....::||:..|::::|.|.|.::..:|.:||.
Human  2342 QRYWPN------ILGKTTMVSNRLRLALVRMQQLKGFVVRAMTLEDIQTREVRHISHLNFTAWPD 2400

  Fly  1129 MGVPAQAKALLDFRRKVNKSYRGRRSCPIVVHGSAGAGRTGVYILLDLVLERMNKGAREIDIAAT 1193
            ...|:|...||.|   ::......||.||:.|.|||.||:|..|.:|:||..:::.. :.||:..
Human  2401 HDTPSQPDDLLTF---ISYMRHIHRSGPIITHCSAGIGRSGTLICIDVVLGLISQDL-DFDISDL 2461

  Fly  1194 LEHLRDQRAGVVATRQQFEF---VLMAVAEEVHA 1224
            :..:|.||.|:|.|..|:.|   |::.|...:.|
Human  2462 VRCMRLQRHGMVQTEDQYIFCYQVILYVLTRLQA 2495

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
IA-2	NP_608562.4	Receptor_IA-2	705..795	CDD:463293	15/89 (17%)
		PTP_DSP_cys	942..1225	CDD:475123	96/310 (31%)
PTPN13	XP_011530467.1	KIND	3..190	CDD:214801
		FERM_F1_PTPN13	571..666	CDD:340715
		B41	573..781	CDD:214604
		PH-like	777..877	CDD:473070
		PDZ1_PTPN13-like	1090..1181	CDD:467285
		PTN13_u3	1177..1367	CDD:465189
		PDZ2-PTPN13_FRMPD2-like	1365..1456	CDD:467254	8/22 (36%)
		PDZ3_PTPN13_FRMPD2-like	1504..1593	CDD:467181	18/102 (18%)
		PDZ4_PTPN13-like	1789..1873	CDD:467182	13/83 (16%)
		PDZ5_PTPN13-like	1884..1970	CDD:467183	20/93 (22%)
		PTPc-N13	2257..2490	CDD:350445	83/252 (33%)