DRSC/TRiP Functional Genomics Resources

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Protein Alignment IA-2 and PTPN12

DIOPT Version :10

Sequence 1:NP_608562.4 Gene:IA-2 / 33277 FlyBaseID:FBgn0031294 Length:1319 Species:Drosophila melanogaster
Sequence 2:XP_047276629.1 Gene:PTPN12 / 5782 HGNCID:9645 Length:807 Species:Homo sapiens


Alignment Length:398 Identity:120/398 - (30%)
Similarity:182/398 - (45%) Gaps:51/398 - (12%)


- Green bases have known domain annotations that are detailed below.


  Fly   929 WSEEPALTNMDISTGHMVLSYMEDHLRNKGRLQREWEALCRYEAE---PSAREAASQPQCAGLNR 990
            |:|   :..:..|.|:.|.|.::.:.::..||:|   ...:|..|   |:|  ...:.:....||
Human    34 WAE---IAPLHSSLGNRVRSCLKTNKQSAVRLRR---LSTKYRTEKIYPTA--TGEKEENVKKNR 90

  Fly   991 PGAPLPYDHSRVVLNHLANAEGLDYVNASTITD-HDPRAPAYVAAQGPLPSTLAHFWQMIWEQGA 1054
            ....||:|||||.|.....::..||:||:.|.. :.|:  ||||.||||.:|:..||:||||...
Human    91 YKDILPFDHSRVKLTLKTPSQDSDYINANFIKGVYGPK--AYVATQGPLANTVIDFWRMIWEYNV 153

  Fly  1055 VVIVALCRLQENGEVACARYWPEEGAEVYHIYEVHLVSEHIWCDDYLVRSFYLKNLRT------S 1113
            |:||..||..|.|...|.||||..|.:     .:......|.|:|...|:.|.  :||      :
Human   154 VIIVMACREFEMGRKKCERYWPLYGED-----PITFAPFKISCEDEQARTDYF--IRTLLLEFQN 211

  Fly  1114 ETRTVTQFHFLSWPHMGVPAQAKALLDFRRKVNKSYRGRRSCPIVVHGSAGAGRTGVYILLDLV- 1177
            |:|.:.|||:::||...||:...::||....:.| |:.....||.:|.|||.||||....:|.. 
Human   212 ESRRLYQFHYVNWPDHDVPSSFDSILDMISLMRK-YQEHEDVPICIHCSAGCGRTGAICAIDYTW 275

  Fly  1178 -LERMNKGAREIDIAATLEHLRDQRAGVVATRQQFEFVLMAVAE---------EVHAILKALPA- 1231
             |.:..|...|.::...::.:|.||...|.|::|:|.|..|:|:         |:|...|.... 
Human   276 NLLKAGKIPEEFNVFNLIQEMRTQRHSAVQTKEQYELVHRAIAQLFEKQLQLYEIHGAQKIADGV 340

  Fly  1232 ---NT-----SGEKRELDKDPVVGGGSSSTTTKEPLKEDKAQEAAEEEAP---TSSSKAAAAAKK 1285
               ||     |.|..:.|..|.....:.|...:...||:..|.......|   |.|..:|.....
Human   341 NEINTENMVSSIEPEKQDSPPPKPPRTRSCLVEGDAKEEILQPPEPHPVPPILTPSPPSAFPTVT 405

  Fly  1286 EKEKDKDK 1293
            ...:|.|:
Human   406 TVWQDNDR 413

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
IA-2NP_608562.4 Receptor_IA-2 705..795 CDD:463293
PTP_DSP_cys 942..1225 CDD:475123 100/303 (33%)
PTPN12XP_047276629.1 PTP_DSP_cys 60..325 CDD:475123 95/279 (34%)
Blue background indicates that the domain is not in the aligned region.

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