Protein Alignment IA-2 and PTPN9

DIOPT Version :10

• Sequence 1: NP_608562.4
• Gene: IA-2 / 33277
• FlyBaseID: FBgn0031294
• Length: 1319
• Species: Drosophila melanogaster
• Sequence 2: NP_002824.1
• Gene: PTPN9 / 5780
• HGNCID: 9661
• Length: 593
• Species: Homo sapiens
• Alignment Length: 591
• Identity: 142/591 - (24%)
• Similarity: 232/591 - (39%)
• Gaps: 148/591 - (25%)

  Fly   718 SWNDGQRIM--KELEQILHMQGYFSY---------LTVQQHEVSFR----------VNSNNPERK 761
            |||...:.:  ::.:.:..::.:.||         :.::.||...|          :|..:|
Human    43 SWNVAVKFLMARKFDVLRAIELFHSYRETRRKEGIVKLKPHEEPLRSEILSGKFTILNVRDP--- 104

  Fly   762 TAGDV----ARTINENRGVKNNIQRRVGFYVLHAGVGD---------VIKDLQDPSVSSSRIELA 813
            |...:    ||..:.::.|::.:.:.: ||:|...|..         .|.|:...:.::..::|
Human   105 TGASIALFTARLHHPHKSVQHVVLQAL-FYLLDRAVDSFETQRNGLVFIYDMCGSNYANFELDL- 167

  Fly   814 EQGPDVTHIMAYMFAG-------AGAAAVIVIFVTLILIKRHDRKRDKLGGLQSGIAGAETCSKD 871
              |..|.:::...|..       .||.....:..::|.:...|:.|:::..|::        |:.
Human   168 --GKKVLNLLKGAFPARLKKVLIVGAPIWFRVPYSIISLLLKDKVRERIQILKT--------SEV 222

  Fly   872 YQELCRARMAGKAGG-----------------GGNSTGGAAGGGSNEPAPSGRITSLSKENEGRP 919
            .|.|.|..:....||                 .|:            |.|...|...|     .|
Human   223 TQHLPRECLPENLGGYVKIDLATWNFQFLPQVNGH------------PDPFDEIILFS-----LP 270

  Fly   920 PSSRSSTSSWSEEPALTNMDISTGH-MVLSYMEDHL--RNKGRLQREWEALCRYEAEPSAREAAS 981
            |:     ..|.      ::.:...| |.:..:.|::  |.|..:..|:|.: |.|........:.
Human   271 PA-----LDWD------SVHVPGPHAMTIQELVDYVNARQKQGIYEEYEDI-RRENPVGTFHCSM 323

  Fly   982 QPQCAGLNRPGAPLPYDHSRVVLNHLANAEGLDYVNASTITDHDPRAPAYVAAQGPLPSTLAHFW 1046
            .|.....||.|.....|.:||.|...:.....||:||| ..|...:..||:..||||.:|...||
Human   324 SPGNLEKNRYGDVPCLDQTRVKLTKRSGHTQTDYINAS-FMDGYKQKNAYIGTQGPLENTYRDFW 387

  Fly  1047 QMIWEQGAVVIVALCRLQENGEVACARYWPEE---------------GAEVYHIYEVHLVSEHIW 1096
            .|:|||..:|||...|.:|.|...|.:|||.|               |.|..:.|:...:..|
Human   388 LMVWEQKVLVIVMTTRFEEGGRRKCGQYWPLEKDSRIRFGFLTVTNLGVENMNHYKKTTLEIH-- 450

  Fly  1097 CDDYLVRSFYLKNLRTSETRTVTQFHFLSWPHMGVPAQAKALLDFRRKV---------NKSYRGR 1152
                        |....:.|.||.|.|||||..|||:.|.:|:||.|.|         |...|.:
Human   451 ------------NTEERQKRQVTHFQFLSWPDYGVPSSAASLIDFLRVVRNQQSLAVSNMGARSK 503

  Fly  1153 RSC---PIVVHGSAGAGRTGVYILLDLVLERMNKGAREIDIAATLEHLRDQRAGVVATRQQFEFV 1214
            ..|   |||||.|||.||||.:..||:.|.::.: ...:::..|:..:|.|||..:.|.:|:.|.
Human   504 GQCPEPPIVVHCSAGIGRTGTFCSLDICLAQLEE-LGTLNVFQTVSRMRTQRAFSIQTPEQYYFC 567

  Fly  1215 LMAVAE 1220
            ..|:.|
Human   568 YKAILE 573

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
IA-2	NP_608562.4	Receptor_IA-2	705..795	CDD:463293	18/101 (18%)
		PTP_DSP_cys	942..1225	CDD:475123	98/309 (32%)
PTPN9	NP_002824.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..21
		CRAL_TRIO_N	20..68	CDD:215024	3/24 (13%)
		SEC14	90..240	CDD:214706	28/164 (17%)
		PTPc-N9	299..569	CDD:350391	92/286 (32%)