Protein Alignment IA-2 and ptpn22

DIOPT Version :10

• Sequence 1: NP_608562.4
• Gene: IA-2 / 33277
• FlyBaseID: FBgn0031294
• Length: 1319
• Species: Drosophila melanogaster
• Sequence 2: NP_001092890.2
• Gene: ptpn22 / 565606
• ZFINID: ZDB-GENE-060503-458
• Length: 901
• Species: Danio rerio
• Alignment Length: 375
• Identity: 110/375 - (29%)
• Similarity: 164/375 - (43%)
• Gaps: 67/375 - (17%)

  Fly   951 EDHLRNKG------RLQREWEALCRYEAE---PSAREAASQPQCAGLNRPGAPLPYDHSRVVLNH 1006
            ||.....|      :|:|:   ..:|.||   |:.  ||.:......||....:|:|||||.|:.
Zfish    21 EDETAENGFAGEFLKLKRQ---STKYRAERTYPTT--AADKQDNVKKNRYKDIVPFDHSRVKLSL 80

  Fly  1007 LANAEGLDYVNASTITDHDPRAPAYVAAQGPLPSTLAHFWQMIWEQGAVVIVALCRLQENGEVAC 1071
            ..:....||:|||.|.... .:.||:|.||||.:|:..||:||||....|||.:||..|.|...|
Zfish    81 FTSKNDTDYINASFIKGVS-GSKAYIATQGPLSNTVLDFWRMIWEYNIKVIVMVCREFEMGRKKC 144

  Fly  1072 ARYWPEEGAEVYHIYEVHLVSEHIWCD----DYLVRSFYLKNLRTSETRTVTQFHFLSWPHMGVP 1132
            .|||||...:|:......::.|   .|    |||.|:  ||.....|:|.:.|.|:::||..|||
Zfish   145 ERYWPESKGDVFVCEAFTILYE---SDENKGDYLTRT--LKVTFKQESRRLKQLHYVNWPDHGVP 204

  Fly  1133 AQAKALLDFRRKVNKSYRGRRSCPIVVHGSAGAGRTGVYILLDLVLERMNKG--AREIDIAATLE 1195
            ....|:|:..::: :.|:.....||.:|.|||.||||....:|.....:.:.  ..:..|...::
Zfish   205 DSIPAILELLQEM-RIYQDNEEIPICIHCSAGCGRTGALCAIDYTWNLLKRQIIPEDFSIFELVK 268

  Fly  1196 HLRDQRAGVVATRQQFEFVLMAVAEEVHAILKALPANTSGEKRELDKDPVVGGGSSSTTTKEPLK 1260
            .:|.||..||.|::|:|.|...:.......|.||
Zfish   269 GMRTQRPSVVQTKEQYELVYRTIKLLFERYLAAL------------------------------- 302

  Fly  1261 EDKAQEAAEEEAPTSSSKAAAAAKKEKEKDKD----KEEKQAKDQAKVAE 1306
                 ||...:.|.|||.|..::..|.....|    ::.:...|:.:|.|
Zfish   303 -----EAPSNKVPDSSSPAMLSSGSELSDISDFSDQEQTEHRNDEIRVDE 347

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
IA-2	NP_608562.4	Receptor_IA-2	705..795	CDD:463293
		PTP_DSP_cys	942..1225	CDD:475123	95/288 (33%)
ptpn22	NP_001092890.2	None