Protein Alignment IA-2 and ptpn9b

DIOPT Version :10

• Sequence 1: NP_608562.4
• Gene: IA-2 / 33277
• FlyBaseID: FBgn0031294
• Length: 1319
• Species: Drosophila melanogaster
• Sequence 2: XP_690659.6
• Gene: ptpn9b / 562170
• ZFINID: ZDB-GENE-090313-52
• Length: 754
• Species: Danio rerio
• Alignment Length: 908
• Identity: 224/908 - (24%)
• Similarity: 339/908 - (37%)
• Gaps: 246/908 - (27%)

  Fly   425 AMDQLEAIV----------EQQQQRELKEQQEQAKAPVYVPPEEVNESSELYFPDNFAPFKRARG 479
            |:...||.|          ||.|..:|..|....|   ::...:.:.|..:   |.|..:|..|
Zfish     4 ALTNQEAAVEEFLAELRCREQSQNADLVSQMTAVK---FLMARKFDVSRAI---DLFQAYKNTR- 61

  Fly   480 RSRGGLAEEVEDEQPKRSFFRELAGEQGLVQEPPLRFRHVETEVDATPELVKRRPASFKQLDPYD 544
                 :.|.:.:..|               .|.|||...:..:....|    .|.|....|..:.
Zfish    62 -----IKEGIYNINP---------------NEEPLRSELLSGKFTVLP----GRDAKGAALALFT 102

  Fly   545 VSLQQQEMAFESGLLRNSLTPLEEEAMLASNSFPRQAKSQRVYTEGGLLLMPQDEQDTDGMQADE 609
            ..|.|.:......:|:..:..|::..             :.|.|:...|:...|..::.....|.
Zfish   103 ARLHQPDRTTHKAVLQAIIYQLDKAI-------------ESVQTQRDGLIFIYDMTNSTYANFDY 154

  Fly   610 PENVKQSLLANMLGFARHERLD----VKKP----GPLLGPPSLGSAELSNQLETEKAHKQKGHGN 666
            ...||   :.|:|..|...||.    |..|    .|..........:|..::.|.|||:...|..
Zfish   155 ELCVK---ILNLLKGAFPARLKCVFIVSSPLWFRAPFAVLRLFVREKLRERVCTVKAHELVNHIP 216

  Fly   667 KEVLPAHIKGNDEDDAHKKKKVMKQQHSAEDHAPHTVDTEYVHV-FVKNPIDSW----NDGQRIM 726
            ...||.|:.|:                           ::|.|: ::::.::|.    |:...:.
Zfish   217 VSSLPEHLGGS---------------------------SQYSHIAWIQSCVNSSPNHPNNSAYVT 254

  Fly   727 KE-LEQIL------HMQGYFS-YLTVQQHEVSF---RVNSNNPERKTAGDVARTINENR-GVKNN 779
            .: |..:|      |.|...: .||.:....:|   .:|||.|          .::||. .|.|:
Zfish   255 GDCLGSLLCSYSMEHDQNTSADPLTAKTSAATFLGDGLNSNCP----------ILDENNANVPNH 309

  Fly   780 IQRRVGFYVLHA-GVGDVIKDLQDPSVSSSRIELAEQG----------PDV----THIMAYMFAG 829
              |..|    || ..|..:     ||:.|:...|..:|          ||.    .|.......|
Zfish   310 --RMTG----HAHWNGSAL-----PSLGSNANVLNGRGRQPPPQSDTPPDTPLHQKHTAGGGILG 363

  Fly   830 AGAAAVIVIFVTLILIKRHDRKRDKLGGLQSGIAGAETCSKDYQELCRARMAGKAGGGGNSTGGA 894
            .|.|.:             |..|      |.| .|||...:|. ||....|     |.|:..
Zfish   364 VGGACL-------------DASR------QDG-NGAEESQQDV-ELLEDEM-----GEGDGV--- 399

  Fly   895 AGGGSNEPAPSGRITSLSKENEGRPPSSRSSTS---SW-----SEEPALTNMDISTGHMVLSYME 951
                  .|.|.          :.|||....|.:   ||     :|...|:......|.|.:..:.
Zfish   400 ------PPLPL----------KSRPPPLNHSPTPDMSWLPGMLTETTMLSVHVAEPGGMSVQDLV 448

  Fly   952 DHLRNKGR--LQREWEALCRYEAEPSA------REAASQPQCAGLNRPGAPLPYDHSRVVLNHLA 1008
            .|::.|.:  :.:|:|.:   ..||.|      ::|::|.:    ||....|..|.|||   ||.
Zfish   449 QHVKRKKKKGIYQEYEEI---RKEPPAGTFDYSKKASNQIK----NRYSDVLCLDQSRV---HLC 503

  Fly  1009 -----NAEGLDYVNASTITDHDPRAPAYVAAQGPLPSTLAHFWQMIWEQGAVVIVALCRLQENGE 1068
                 :.|..||:||| ..|....:.||:|.|||||.|...||:|:|||..::||...|:.|.|.
Zfish   504 PLNDEDDETSDYINAS-FMDGYKWSNAYIATQGPLPKTFGDFWRMVWEQMVLIIVMTTRVVERGR 567

  Fly  1069 VACARYWPEEG--AEVYHIYEVHLVSEHIWCDDYLVRSFYLKNLRTSETRTVTQFHFLSWPHMGV 1131
            |.|.:|||.|.  .|.|..:.|..|...:: .|:.:....|.|.:|.|.|.|:.:.::|||..||
Zfish   568 VKCGQYWPLEAGRTEEYGYFLVRNVHIEVF-QDFKLSHLELFNTQTGECREVSHYLYMSWPDFGV 631

  Fly  1132 PAQAKALLDFRRKVNKSYRGRRSC--------------PIVVHGSAGAGRTGVYILLDLVLERMN 1182
            |..|.|:||||..|  .:|...|.              |:|||.|||.||||.:..||:.|.|:
Zfish   632 PKSASAMLDFRAHV--KHRQESSLRTLYPDWTGPPGGPPVVVHCSAGIGRTGTFCTLDICLSRL- 693

  Fly  1183 KGAREIDIAATLEHLRDQRAGVVATRQQFEFVLMAVAE--EVHAILKALPANTSGEKRELDKD 1243
            :....:||..|:..:|.|||..:.|..|:.|...||.|  :...:|:  |...|..:.|.|.:
Zfish   694 EDIGTVDIKQTVRRMRTQRAFSIQTWDQYYFCYKAVIEYGQQSGLLQ--PVEWSDTELETDSE 754

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
IA-2	NP_608562.4	Receptor_IA-2	705..795	CDD:463293	23/107 (21%)
		PTP_DSP_cys	942..1225	CDD:475123	107/313 (34%)
ptpn9b	XP_690659.6	None