Protein Alignment IA-2 and ptpn11

DIOPT Version :10

• Sequence 1: NP_608562.4
• Gene: IA-2 / 33277
• FlyBaseID: FBgn0031294
• Length: 1319
• Species: Drosophila melanogaster
• Sequence 2: XP_012818337.1
• Gene: ptpn11 / 549586
• XenbaseID: XB-GENE-22063677
• Length: 596
• Species: Xenopus tropicalis
• Alignment Length: 590
• Identity: 141/590 - (23%)
• Similarity: 239/590 - (40%)
• Gaps: 145/590 - (24%)

  Fly   758 PERKTAGDVARTINENRGVKN-NIQRRVGFYVLHAGV-----------------------GDVIK 798
            |.:...||...::..|..|.: .||....:|.|:.|.                       ||||:
 Frog    33 PSKSNPGDFTLSVRRNGAVTHIKIQNTGDYYDLYGGEKFATLAELVQYYMEHHGQLKEKNGDVIE 97

  Fly   799 -----DLQDPS--------VSSSRIE--LAEQGPDVTHIMAYMFAGAGAAAVIV----------- 837
                 :..||:        :|....|  |.|:|...:.::....:..|...:.|
 Frog    98 LKYPLNCADPTSERWFHGHLSGKEAEKLLTEKGKHGSFLVRESQSHPGDFVLSVRTGDDKAESND 162

  Fly   838 --IFVTLILIKRHDRKRDKLGGLQSGIAGAETCSKDYQELCRARMAGKAGGGGNSTGGAAGGGSN 900
              ..||.::|:..|.|.|                                         .|||..
 Frog   163 GKSKVTHVMIRCQDLKYD-----------------------------------------VGGGEK 186

  Fly   901 EPAPSGRITSLSKENEGRPPSSRSSTSSWSEEPALTNMDISTGHMVLSYMEDHLRN--------- 956
            ..:    :|.|.:..:..|......|....::|      ::|..:..:.:|..::.
 Frog   187 FDS----LTDLVEHYKKNPMVETLGTVLQLKQP------LNTTRINAAEIESRVKELSKPAETAD 241

  Fly   957 --KGRLQREWEALCRYEAE-PSAREAASQPQCAGLNRPGAPLPYDHSRVVLNH-LANAEGLDYVN 1017
              |.....|:|.|.:.|.: ..:|:...:.:....||....||:||:||.|:. ..|.:..||:|
 Frog   242 KFKQGFWEEFETLQQQECKLLYSRKEGQRQENKNKNRYKNILPFDHTRVELHDGDPNEQVSDYIN 306

  Fly  1018 ASTITD------HDPR-APAYVAAQGPLPSTLAHFWQMIWEQGAVVIVALCRLQENGEVACARYW 1075
            |:.|..      ::|: ...|:|.||.|.:|:..||:|::::.:.|||...:..|.|:..|.:||
 Frog   307 ANIIMPEFETKCNNPKPKKRYIATQGCLQNTVNDFWRMVFQENSRVIVMTTKEVERGKSKCVKYW 371

  Fly  1076 PEEGA-EVYHIYEVHLVSE---HIWCDDYLVRSFYLKNLRTSET-RTVTQFHFLSWPHMGVPAQA 1135
            |:|.| :.|.:..|..|.|   |    ||::|...|..:....| |||.|:||.:||..|||...
 Frog   372 PDEFALKEYGVMRVRNVKETPAH----DYILRELKLSKVGQGNTERTVWQYHFKTWPDHGVPTDP 432

  Fly  1136 KALLDFRRKVNKSYRGRRSC-PIVVHGSAGAGRTGVYILLDLVLERM-NKGAR-EIDIAATLEHL 1197
            ..:|||..:|:....|.... |:|||.|||.||||.:|::|::::.: .||.. :||:..|::.:
 Frog   433 GGVLDFLEEVHHKQDGIADAGPVVVHCSAGIGRTGTFIVIDILIDVIREKGVDCDIDVPKTIQMV 497

  Fly  1198 RDQRAGVVATRQQFEFVLMAVAEEVHAILKALPANTSGEKRELDKDPVVGGGSSSTTTKEPLKED 1262
            |.||:|:|.|..|:.|:.|||...:..:.:.:......:::          |...|..|..|.|.
 Frog   498 RSQRSGMVQTEAQYRFIYMAVQHYIETLQRRIEEEQKSKRK----------GHEYTNIKYSLSEQ 552

  Fly  1263 KAQEA 1267
            ...::
 Frog   553 AGDQS 557

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
IA-2	NP_608562.4	Receptor_IA-2	705..795	CDD:463293	10/60 (17%)
		PTP_DSP_cys	942..1225	CDD:475123	99/310 (32%)
ptpn11	XP_012818337.1	SH2_N-SH2_SHP_like	5..103	CDD:198203	14/69 (20%)
		SH2_C-SH2_SHP_like	111..218	CDD:198185	21/157 (13%)
		PTPc-N11	272..524	CDD:350453	91/255 (36%)