Protein Alignment IA-2 and ptpn11b

DIOPT Version :10

• Sequence 1: NP_608562.4
• Gene: IA-2 / 33277
• FlyBaseID: FBgn0031294
• Length: 1319
• Species: Drosophila melanogaster
• Sequence 2: NP_001015717.1
• Gene: ptpn11b / 548434
• XenbaseID: XB-GENE-6054495
• Length: 594
• Species: Xenopus tropicalis
• Alignment Length: 697
• Identity: 164/697 - (23%)
• Similarity: 269/697 - (38%)
• Gaps: 182/697 - (26%)

  Fly   642 PSLGSAELSNQLETEKAHKQKGHGNKEVLPAHIKGNDEDDAHKKKKVMKQQHSAEDHAPHTVDTE 706
            |::...|....|.|     ..|||:....|:  |.|..|..     :..::|:           |
 Frog     9 PNISGQEAETLLLT-----NGGHGSFLARPS--KSNPGDFT-----LSVRRHN-----------E 50

  Fly   707 YVHVFVKNPIDSWN--DGQRI--MKELEQILHMQGYFSYLTVQQH----------EVSFRVNSNN 757
            ..|:.::|..|.::  .|:..  :.||.|         |.|.||.          |:.:.:||.:
 Frog    51 VTHIKIQNTGDYYDLYGGETFATLAELVQ---------YYTEQQGLLREKNGDVIELKYPLNSQD 106

  Fly   758 P--ER----KTAGDVARTINENRGVKNNI-----QRRVGFYVLHAGVGDVIKDLQDPSVSSSRIE 811
            |  ||    ..:|..|..:..::|...:.     |.:.|.:||..            ..|..::|
 Frog   107 PTSERWYHGHLSGKEAEKLLLDKGKPGSFLVRESQSKPGDFVLSV------------LTSEEKLE 159

  Fly   812 LAEQGPDVTHIMAYMFAGAGAAAVIVIFVTLILIKRHDRKRDKLGGLQSGIAGAETCSKDYQELC 876
            ..|:...|||:|...                    :.|.|.|
 Frog   160 NGERKSRVTHVMIRF--------------------QPDGKYD----------------------- 181

  Fly   877 RARMAGKAGGGGNSTGGAAGGGSNEPAPSGRITSLSKENEGRPPSSRSSTSSWSEEP----ALTN 937
                              .|||..    ...:|.|....:..|...:|......::|    .:..
 Frog   182 ------------------VGGGER----FDTLTDLLDHYKKNPMVEKSGAVVHLKQPFNATRINA 224

  Fly   938 MDISTGHMVLSYMEDHL-RNKGRLQREWEALCRYEAE---PSAREAASQPQCAGLNRPGAPLPYD 998
            .:|.|....|:...|:. :.|.....|:|.|.:.|.:   |  |:...:|:....||....||:|
 Frog   225 ANIETRVRELNKTADNTEKAKQGFWEEFEMLQQQECKLLYP--RKEGQRPENKSKNRYKNILPFD 287

  Fly   999 HSRVVLNHL-ANAEGLDYVNASTI--TDHDPRA----PAYVAAQGPLPSTLAHFWQMIWEQGAVV 1056
            .:||.|... .:..|.||:||:.|  |..:.|.    ..|:|.||.|.:|:..||.|::::...|
 Frog   288 TTRVTLRDTDESVAGSDYINANYIKSTLDEARGSQHYKVYIATQGCLQNTVCDFWAMVYQENTHV 352

  Fly  1057 IVALCRLQENGEVACARYWPEEG-AEVYHIYEVHLVSEHIWCDDYLVRSFYLKNL-RTSETRTVT 1119
            ||...:..|.....|.||||:|. .:.|....|..: |.....||::|...:..: :....|.:.
 Frog   353 IVMTTKEVERSRKKCFRYWPDENCTKDYGCIRVQSL-EVQQKKDYILRELQISRMDKVESPRPIW 416

  Fly  1120 QFHFLSWPHMGVPAQAKALLDFRRKVNKSYRG-RRSCPIVVHGSAGAGRTGVYILLDLVLERMNK 1183
            .:.:||||..|||.:...:|.|..::|.:.:. ..|.|||||.|||.||||..|::|::::.:|:
 Frog   417 HYQYLSWPDHGVPIEPGGVLSFLEEINAAQKYIPHSGPIVVHCSAGIGRTGTIIVIDMLVDIINR 481

  Fly  1184 GAR--EIDIAATLEHLRDQRAGVVATRQQFEFVLMAVAEEVHAILKALPANTSGEKRELDKDPVV 1246
            ...  :|||..|::.:|.||:|:|.|..|::|:.|||.:.:..           .||.|:::.:
 Frog   482 QGLDCDIDIPKTIQMVRQQRSGMVQTEAQYKFIYMAVQKYIEV-----------RKRHLEEEQM- 534

  Fly  1247 GGGSSSTTTKEPLKE---DKAQEAAEEEAPTSSSKAAAAAKKEKEKD 1290
                      ..|||   ...|.:..|.|.|.:..|||.::.....|
 Frog   535 ----------GKLKEREYTNIQYSVGERARTKAQPAAAQSQHRVSDD 571

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
IA-2	NP_608562.4	Receptor_IA-2	705..795	CDD:463293	25/114 (22%)
		PTP_DSP_cys	942..1225	CDD:475123	94/298 (32%)
ptpn11b	NP_001015717.1	SH2_N-SH2_SHP_like	5..103	CDD:198203	25/125 (20%)
		SH2_C-SH2_SHP_like	111..219	CDD:198185	26/184 (14%)
		PTPc-N11_6	274..523	CDD:350392	83/249 (33%)