Protein Alignment IA-2 and ptpn18

DIOPT Version :10

• Sequence 1: NP_608562.4
• Gene: IA-2 / 33277
• FlyBaseID: FBgn0031294
• Length: 1319
• Species: Drosophila melanogaster
• Sequence 2: XP_068079039.1
• Gene: ptpn18 / 541324
• ZFINID: ZDB-GENE-050320-12
• Length: 514
• Species: Danio rerio
• Alignment Length: 308
• Identity: 94/308 - (30%)
• Similarity: 144/308 - (46%)
• Gaps: 24/308 - (7%)

  Fly   935 LTNMDISTGHMVLSYMEDHLRNKGRLQREWEALCRYEAEPSAREAASQPQCAGLNRPGAPLPYDH 999
            |:|.|.| |..::|.....:|.|....:|...|        ...|....:....||....||||.
Zfish    16 LSNHDRS-GDQLISSEFSLIRKKTASLKEDYGL--------TTNAGGMKENVKKNRYRDILPYDQ 71

  Fly  1000 SRVVLNHLANAEGLDYVNASTITDHDPRAPAYVAAQGPLPSTLAHFWQMIWEQGAVVIVALCRLQ 1064
            :||.|....:....||:||:.:.. ..|...|:|.||||.||:..||:|||:....||:..||..
Zfish    72 TRVCLTPTTSEYQSDYINANFVKG-AVRNRTYIATQGPLSSTVVDFWRMIWQHNVKVIIMACREI 135

  Fly  1065 ENGEVACARYWPE-EGAEVYHIYEVHLVSEHIWCDDYLVRSFYLKNLRTSETRTVTQFHFLSWPH 1128
            |.|:..|..||.. ........:.|..:.|....::.:||:..:.  ...|.|.|:.|.:.:||.
Zfish   136 EMGKKKCEVYWASTSDTSTLGPFTVSTLEESRPNEEVIVRTLVVN--YCDEARKVSHFQYTAWPD 198

  Fly  1129 MGVPAQAKALLDFRRKVNKSYRGRRSCPIVVHGSAGAGRTGVYILLD-----LVLERMNKGAREI 1188
            .|:|.....:|.. .::.:..:|.::.|:|:|.|||.|||||...:|     |:.|::.:....:
Zfish   199 HGIPDMPDGILGM-MELARQKQGNQTDPVVIHCSAGCGRTGVICAVDYVNDLLLTEQIQEDFNIL 262

  Fly  1189 DIAATLEHLRDQRAGVVATRQQFEFVLMAVAEEVHAIL--KALPANTS 1234
            |:  .|| ||.||...|.|::|:.||...||:.....|  |.:.|:||
Zfish   263 DL--VLE-LRRQRPSAVQTKEQYGFVFHTVAQMFQKALEMKNMNADTS 307

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
IA-2	NP_608562.4	Receptor_IA-2	705..795	CDD:463293
		PTP_DSP_cys	942..1225	CDD:475123	85/288 (30%)
ptpn18	XP_068079039.1	PTPc-N18	28..293	CDD:350451	84/279 (30%)