Protein Alignment IA-2 and Ptpn13

DIOPT Version :10

• Sequence 1: NP_608562.4
• Gene: IA-2 / 33277
• FlyBaseID: FBgn0031294
• Length: 1319
• Species: Drosophila melanogaster
• Sequence 2: XP_038948202.1
• Gene: Ptpn13 / 498331
• RGDID: 1563360
• Length: 2465
• Species: Rattus norvegicus
• Alignment Length: 1396
• Identity: 300/1396 - (21%)
• Similarity: 450/1396 - (32%)
• Gaps: 422/1396 - (30%)

  Fly    21 RQQHPCTTTEEPKHQRARGTAGHQESATGECQQFWSKQRPPFDQQQQQEDQDPEQDPQQHPSTPQ 85
            |:|..|..||.|         |..:|              ..|.......|| .|.|:|.||:|.
  Rat  1294 RRQGTCDVTELP---------GCADS--------------DIDDPTYSSSQD-RQAPKQEPSSPL 1334

  Fly    86 E-------SVHHHRSPRQHELLHHQ-RKVPPTLPARGRHLISEGARRREVRGCGAGGGGLLCCSL 142
            :       :.....||...:....: .|...:|......|..:|.....||     .||:...::
  Rat  1335 KASDKMSFAAFPGPSPEPGDAFEVELAKTDGSLGISVTVLFDKGGVNTSVR-----HGGIYVKAV 1394

  Fly   143 ---DALSRPAKLLQFGVLLLI----LLLATHGDLAQAEGNVGCQFVRTLC-----------IPHS 189
               .|.....::.:...:|.:    |..|||....:...|.| |.|..|.           .|.|
  Rat  1395 IPNGAAETDGRIHKGDRVLAVNGVSLEGATHKQAVETLRNTG-QVVHLLLEKGQSPTSRERDPAS 1458

  Fly   190 EVCYDDNIFGKCIPTTGVDV-----EDIEK-TPLTEDQSRVLATMLEELQ----GAGLGWDHPYV 244
            ..|          ||...|.     |.:|| |...:|.|.|......|::    .:|||
  Rat  1459 PRC----------PTPDQDAQSQAPEKMEKQTAHVKDYSFVTEDNTFEVKLFKNSSGLG------ 1507

  Fly   245 QCRIQGSLFSLQRQQQLPPNL-------CANLAPTPP-------EFGD--------PASALAY-- 285
                    ||..|:..|.|.|       ...|.|..|       ..||        |...|:.
  Rat  1508 --------FSFSREDNLTPELINGSIVRVKKLFPGQPAAESGKINVGDVILKVNGAPLKGLSQQD 1564

  Fly   286 ----VRFTPPE-------------PEAELDYYEQPAGPAQFYPALRKKQVRESDADDMYLNRMLQ 333
                :|.|.||             ||...........||..:...||:..:.|
  Rat  1565 VISALRGTAPEVSLLLCRPAPGVLPEVNTALLTPLHSPAHAFLNSRKEHSQPS------------ 1617

  Fly   334 DRRRLRHDPSELEHFGKMDGHGQS----TQLDAPSIMDAFLDTERQRIEREQQLAAAEQDADRRA 394
                    |..:|.....|.:|.|    .|...||..:::.| .....|.|...|||:.
  Rat  1618 --------PLSVEQCASSDENGLSGQSKRQCKPPSRRESYSD-HSDSGEEESVRAAAKM------ 1667

  Fly   395 EQNRLELYQILAASEPDPQPYQRKPAAQPNAMDQLEAIVEQQQQRELKEQQEQAKAPVYVPPEEV 459
             .|.:.    |:|..|:....|.:||:....:.:......:.:...|....:.:...:..||.|.
  Rat  1668 -PNVIP----LSAFAPEALRSQGEPASTMFYLPRKIPGKPESESSRLPHPLDVSPGQIRQPPAEC 1727

  Fly   460 NES-----------SELYFPDNFAPFKRARGRSRGGLAEEVE-----DEQPKRSF-FRELAGEQG 507
            ..|           |:|:..:|....|...|........|||     .:..|.|. |....|.|.
  Rat  1728 APSDSPGKHLTHLASQLHKEENMTALKNDLGNHLEDSELEVELLITLVKSEKGSLGFTVTKGSQS 1792

  Fly   508 L-------VQEPPL---RFRHVE-------------TEVD------ATPELVK----------RR 533
            :       :|:|..   |.|..:             |..|      |.|:.|:          |.
  Rat  1793 IGCYVHDVIQDPAKGDGRLRPGDRLVKVNDADVTNMTHTDAVNLLRAAPKTVRLVIGRILELPRM 1857

  Fly   534 PASFKQLDPYDVSLQQQEMAFESGLLRNSLTPLEEEAMLASNSFPRQAKSQRVYTEGGLLLMP-- 596
            |.....|....|:...:|:.|.....|.|    ....:..|:..||.|.:    .:..|.|:.
  Rat  1858 PVFPHLLPDITVTCHGEELGFSLSGGRGS----PHGVVYISDINPRSAAA----VDCSLQLLDII 1914

  Fly   597 --QDEQDTDGMQADEPENVKQSLLANMLGFARHERLDVKKPGPLLGPPSLGSA-ELSNQLETEKA 658
              .:...|.||..:|........|.:::       |.|.:.|..:.|.|..|| .....||....
  Rat  1915 HYVNGVSTHGMTLEEANRALDLSLPSVV-------LKVTRDGCPVVPCSTRSAISALRPLEANGL 1972

  Fly   659 HKQKGHGNKEVLP----AHIKGNDEDDA--------HKKKKVMKQQHSAEDHAPHTVDTEYVHVF 711
            ...:.:|...:.|    :.:.|:....|        ...:|.......|.|.:....|:
  Rat  1973 SSMEPYGQPALTPKKSFSKVNGDGASGAMCPGGKGLSSPRKKSADLMEARDFSFQESDS------ 2031

  Fly   712 VKNPIDSWNDGQRIMKELEQILHMQGYFSYLTVQQHEVSFRVNSNNPERKTAG-DVARTINENRG 775
              ...|.::|.|    |.|.|.      |.|.|...|....:|.....|:... |..||
  Rat  2032 --RDDDVYDDPQ----EAEVIQ------SLLDVVDEEAQNLLNQTKASRRACSPDPLRT------ 2078

  Fly   776 VKNNIQRRVGFYVLHAGVGDVIKDLQDPSVSSSRIELAEQGPDVTHIMAYMFAGAGAAAVIVIFV 840
                             .|:..:|.:|.....|  .|.|..|:..:      .|.|.|.    |.
  Rat  2079 -----------------NGEASEDGEDTDCDGS--PLPEDVPESVN------GGGGKAC----FA 2114

  Fly   841 TLILIKRHDRKRDKLGGLQSGIAGAET-----CSKDYQELCRARMAGKAGGGGNSTGGAAGGGSN 900
            :||...:.::...:....:|..:..||     .|||...|....:|.
  Rat  2115 SLIQASQEEKPVKEEATQESRESTTETTDREDSSKDPLFLTNEELAA------------------ 2161

  Fly   901 EPAPSGRITSLSKENEGRPPSSRSSTSSWSEEPALTNMDISTGHMVLSYME--DHLRNKGRLQRE 963
              .|..|:          |||.:                 .||..:.:.:.  ..|.::|...:|
  Rat  2162 --LPVVRV----------PPSGK-----------------YTGTQLQATIRTLQGLLDQGIPSKE 2197

  Fly   964 WEALCRYEAEPSAREAASQPQC--------AGLNRPGAPLPYDHSRVVLNHLANAEGLDYVNAST 1020
            .|.|         :|.....||        ...||....||||.:||.|..    || .|:|||.
  Rat  2198 LENL---------QELKPLDQCLIGQTKENRRKNRYKNILPYDTTRVPLGD----EG-GYINASF 2248

  Fly  1021 ITDHDPRAP------AYVAAQGPLPSTLAHFWQMIWEQGAVVIVALCRLQENGEVACARYWPEEG 1079
            |     |.|      .|:|.|||||:|:..||||:|||.:.||..:.:..|..::.|.||||.
  Rat  2249 I-----RIPVGTQEFVYIACQGPLPTTVGDFWQMVWEQNSTVIAMMTQEVEGEKIKCQRYWPS-- 2306

  Fly  1080 AEVYHIYEVHLVSEHI--------WCDDYLVRSFYLKNLRTSETRTVTQFHFLSWPHMGVPAQAK 1136
                .:....:.:|.:        ....::||...|::::|.|.|.::..:|.:||....|:..:
  Rat  2307 ----ILGTTTMANERLRLALLRMQQLKGFVVRVMALEDIQTGEVRHISHLNFTAWPDHDTPSHPE 2367

  Fly  1137 ALLDFRRKVNKSYRGRRSCPIVVHGSAGAGRTGVYILLDLVLERMNKGAREIDIAATLEHLRDQR 1201
            .||.|   ::.....|||.|::.|.|||.||:|..|.:|:||..:::.. |.||:..:..:|.||
  Rat  2368 DLLTF---ISYMRHIRRSGPVITHCSAGIGRSGTLICIDVVLGLISQDL-EFDISDLVRCMRLQR 2428

  Fly  1202 AGVVATRQQFEFVLMAV--------AEEVHA 1224
            .|:|.|..|:.|....|        |||..|
  Rat  2429 HGMVQTEGQYVFCYQVVLYVLTHLQAEEQKA 2459

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
IA-2	NP_608562.4	Receptor_IA-2	705..795	CDD:463293	15/90 (17%)
		PTP_DSP_cys	942..1225	CDD:475123	96/315 (30%)
Ptpn13	XP_038948202.1	KIND	3..190	CDD:214801
		FERM_F1_PTPN13	564..659	CDD:340715
		B41	566..774	CDD:214604
		PH-like	770..870	CDD:473070
		PDZ1_PTPN13-like	1081..1172	CDD:467285
		PTN13_u3	1168..1356	CDD:465189	19/85 (22%)
		PDZ2-PTPN13_FRMPD2-like	1354..1445	CDD:467254	19/96 (20%)
		PDZ3_PTPN13_FRMPD2-like	1494..1583	CDD:467181	21/102 (21%)
		PDZ4_PTPN13-like	1767..1851	CDD:467182	17/83 (20%)
		PDZ5_PTPN13-like	1862..1948	CDD:467183	19/100 (19%)
		PTPc-N13	2216..2449	CDD:350445	82/252 (33%)