Protein Alignment IA-2 and ptprz1a

DIOPT Version :10

• Sequence 1: NP_608562.4
• Gene: IA-2 / 33277
• FlyBaseID: FBgn0031294
• Length: 1319
• Species: Drosophila melanogaster
• Sequence 2: XP_005163194.2
• Gene: ptprz1a / 497461
• ZFINID: ZDB-GENE-090406-1
• Length: 1827
• Species: Danio rerio
• Alignment Length: 1256
• Identity: 260/1256 - (20%)
• Similarity: 410/1256 - (32%)
• Gaps: 429/1256 - (34%)

  Fly   207 VDVEDIEKTPLT-----EDQSRVLATMLE--------------ELQGAGLGWDHPYVQCRIQGSL 252
            ::|||:.: |:|     |:.|:.:|.:||              .|:........|..      :.
Zfish   574 LEVEDVTE-PVTITDSFEESSQTVAPLLEIPVDSTSSTFPSEVPLRPTAASLPFPTT------AA 631

  Fly   253 FSLQRQQQLPPNLCANLAPTPPEFGDPASALAYVRFTP------------PEPEAELDYY----- 300
            ||....|...|......||..|...|   .|:||..:|            |.|:.::.|.
Zfish   632 FSTVLSQTTQPVFNGESAPYAPSVSD---TLSYVHASPVSPYSLSSVLSEPIPDWDIPYTVTMLV 693

  Fly   301 ---EQPAGPAQFYPALRKKQVRESDADDMYLNRMLQDRRRLRHDPSELEHFGKMDGHGQSTQLDA 362
               .|...|:..||.|      .......||            |...:...|.:|..|.
Zfish   694 SGGAQSITPSPSYPTL------SLSGSVSYL------------DMESVSSGGCIDDDGD------ 734

  Fly   363 PSIMDAFLDTERQRIEREQQLAAAEQDADRRAEQNRLELYQILAASEPDPQPYQRKPAAQPNAMD 427
                ||.|.            .:|..|...|.......|.::.|:.:      ..:|:::|:.:
Zfish   735 ----DAVLS------------GSASADPPCRTTLPLQTLSEVTASVD------LMQPSSEPSLL- 776

  Fly   428 QLEAIVEQQQQRELKEQQ---EQAKAPVYVPP-----EEVNESSELYFPDNFAPFKRARGRSRGG 484
                        .|.|..   .....|.|:.|     ::.:|::...  |..|....:.|.| ..
Zfish   777 ------------HLSEHSGTISVLSTPAYLQPSVPVSKDYSETTTTL--DTDASLSGSNGES-NL 826

  Fly   485 LAEEVEDEQPKRSF---FRELAGEQGLVQEPPLRFRHVETEVDATPELVKRRPASFKQLDPYDVS 546
            |.|.|:......:|   |...|....|          :.:.|...|      |.|.....|.::.
Zfish   827 LTEWVDSSLAAPTFSSKFSLHASSNSL----------LPSSVSGLP------PCSSLLSSPVELH 875

  Fly   547 LQQQEMAFESGLLRNSLTPLEEEAMLASNSFPRQAKSQRVYTEGGLLLMPQDEQDTDGMQADEPE 611
            |.|...:..:.|..::...|..:|:|.|.|...:..|                 |.....|....
Zfish   876 LFQSTSSASTSLCSDAGLDLSTKALLPSLSISTKPSS-----------------DLSLSVAATVN 923

  Fly   612 NVKQSLLANMLGFARHERLDVKKPGPLLG-----------------------------PPSL--G 645
            |:.||.:...||.:...|.....|.|:|.                             ||::  .
Zfish   924 NIAQSAIGQSLGASAPIRSSAITPTPILELRSTPTPVVPPTIAPTSPSDSITVVAPVVPPTIPVS 988

  Fly   646 SAELSNQLETEKAHKQK-----------------GHGNKEVL--------PAHIKGNDEDDAHKK 685
            ||..|:.:.|..|..|:                 ..|::.:.        |..:...:.||.:
Zfish   989 SAPESSSMPTHSADGQQENSASGWTFDLDWGQSSASGDESIAAPYITTASPTEVSPEETDDGN-- 1051

  Fly   686 KKVMKQQHSAEDH--APHTVDTEYVHVFVK-NPIDSW---NDGQRIMKELEQILHMQGYFSYLTV 744
                 ::||:..:  ..:..::|.....|. .|..||   ..|:          ...|....||.
Zfish  1052 -----EEHSSSFYFEGENGTESEVTDFRVTLQPSPSWTLRGSGE----------EESGSGETLTD 1101

  Fly   745 QQHEVSFRV---NSNNPERKTAGDVARTINENR-GVKNNIQRR---------------------V 784
            .:....|.:   .....|.:...|...:.:|:| |:.::|:|:                     :
Zfish  1102 NETSSDFSIPERTERESEEEPVEDANNSSHESRVGLASSIERQKKAVVPLAVVSTLTFLGLIFLI 1166

  Fly   785 GFYV--------LHAGVGDVIKDLQDPSVSSSRIELAEQGPDVTHIMAYMFAGAGAAAVIVIFVT 841
            |.|:        .|.    .|:|...|.|.||...|
Zfish  1167 GIYIYWRKCFQTAHF----YIEDSTSPRVISSSPLL----------------------------- 1198

  Fly   842 LILIKRHDRKRDKLGGLQSGIAGAETCSKDYQELCRARMAGKAGGGGNSTGGAAGGGSNEPAPSG 906
                                                           |.|      |.:||.|..
Zfish  1199 -----------------------------------------------NPT------GEHEPLPVK 1210

  Fly   907 RITSLSKENEGRPPSSRSSTSSWSEEPALTNMDISTGHMVLSYMEDHLRNKGRLQREWEALCRYE 971
            :..:                                 |:.      .|.|.....||:|.|..|.
Zfish  1211 QFVN---------------------------------HVT------ELHNTSSFSREFEILKEYF 1236

  Fly   972 AE--------PSAREAASQPQCAGLNRPGAPLPYDHSRVVLNHLANAEGL---DYVNASTITDHD 1025
            .|        .:..:.::.|.....||....|.||||||.|..|.:.:|.   ||:||:.: |..
Zfish  1237 EEVQTCTVDLGTTTDCSNHPDNKNKNRYVNILAYDHSRVRLAPLNDKDGKSGGDYINANYV-DGF 1300

  Fly  1026 PRAPAYVAAQGPLPSTLAHFWQMIWEQGAVVIVALCRLQENGEVACARYWPEEGAEVYHIYEVHL 1090
            .:..||:||||||.|:...||:|:|||...|||.:..|.|.|...|.:|||.|..|.|..:.|.:
Zfish  1301 NKNKAYIAAQGPLKSSTPDFWRMVWEQNVGVIVMITNLVEKGRKKCDQYWPLENQEEYGCFLVTV 1365

  Fly  1091 VSEHIWCDDYLVRSFYLKN---------LRTSETRTVTQFHFLSWPHMGVPAQAKALLDFRRKVN 1146
            .|.::.. .|..|:|.|:|         .|::| |||||:|:..||.||||.....:|.|..|.:
Zfish  1366 KSTNVLA-YYTKRTFTLRNTSIKKGSQRYRSNE-RTVTQYHYTQWPDMGVPEYVLPVLSFVYKSS 1428

  Fly  1147 KSYRGRRSCPIVVHGSAGAGRTGVYILLDLVLERM-NKGAREIDIAATLEHLRDQRAGVVATRQQ 1210
            |:...... |:|||.|||.||||.||:||.:|::: .||.  ::|...|:|:|.||..:|.|.:|
Zfish  1429 KAQTDGMG-PMVVHCSAGVGRTGTYIVLDSMLKQIKEKGT--VNIMGFLKHIRTQRNYLVQTEEQ 1490

  Fly  1211 FEFVLMAVAEEVHAILKALPANTSGEKRELDKDPVVGGGSSSTTTKEPLK---EDKAQE----AA 1268
            :.|...|:.|   |||......:|....:...:.:..|.|..|..::..|   :..|::    ||
Zfish  1491 YIFTHDALVE---AILSQETEVSSSHIHQYVNNLLTPGASCKTRLEKQFKLVCQSNAKQNDCSAA 1552

  Fly  1269 EEEAPTSSSKAAAAAKKEKEK 1289
            ..:...:.::..:....||.:
Zfish  1553 LSDCNRTKNRNCSLIPVEKSR 1573

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
IA-2	NP_608562.4	Receptor_IA-2	705..795	CDD:463293	20/126 (16%)
		PTP_DSP_cys	942..1225	CDD:475123	110/303 (36%)
ptprz1a	XP_005163194.2	None