Protein Alignment IA-2 and csw

DIOPT Version :9

• Sequence 1: NP_608562.4
• Gene: IA-2 / 33277
• FlyBaseID: FBgn0031294
• Length: 1319
• Species: Drosophila melanogaster
• Sequence 2: NP_477131.1
• Gene: csw / 45278
• FlyBaseID: FBgn0000382
• Length: 945
• Species: Drosophila melanogaster
• Alignment Length: 825
• Identity: 181/825 - (21%)
• Similarity: 304/825 - (36%)
• Gaps: 240/825 - (29%)

  Fly   641 PPSLGSAELSNQ----LETEKAHKQKG----HGNKEVLPAHIKGND------EDDAHKKKKVMKQ 691
            |.:.|.|..||.    |.|.:. :..|    |||       :.|.:      |...:....|.:.
  Fly   183 PAAFGGASCSNSTLSLLATMRV-QLHGYTWFHGN-------LSGKEAEKLILERGKNGSFLVRES 239

  Fly   692 QHSAEDHAPHT-VDTEYVHVFVKNPIDSWNDGQRIMKELEQILHMQGYFSYLTVQQHEVSFRVNS 755
            |....|..... .|.:..||.::     |.|     |:.:    :.|..|:.|:.:....::
  Fly   240 QSKPGDFVLSVRTDDKVTHVMIR-----WQD-----KKYD----VGGGESFGTLSELIDHYK--- 287

  Fly   756 NNPERKTAGDVA---RTINENRGVKNNIQRRVGFYVLHAGVGDVIKDLQDPSVSS-SRIELAEQG 816
            .||..:|.|.|.   :..|..|.....|..||. .::..|..:..:.||..|..: ||.|..:|.
  Fly   288 RNPMVETCGTVVHLRQPFNATRITAAGINARVE-QLVKGGFWEEFESLQQDSRDTFSRNEGYKQE 351

  Fly   817 PDV----THIMAYMFAGAGAAAVIVIFVTLILIKRHDRKRDKLGGLQSGIAGAETCSKDYQELCR 877
            ..:    .:|:.|                       |..|.||..::..:||||..:.:|..|
  Fly   352 NRLKNRYRNILPY-----------------------DHTRVKLLDVEHSVAGAEYINANYIRL-- 391

  Fly   878 ARMAGKAGGGGNSTGGAAGGGSNEPAPSGRITSLSKENE---GRPPSSRSSTSSWSEEPA----- 934
                                     ...|.:.::|..:|   ...||..:.|::.::...
  Fly   392 -------------------------PTDGDLYNMSSSSESLNSSVPSCPACTAAQTQRNCSNCQL 431

  Fly   935 --LTNMDISTGHMVLSYMEDHLRNKGRLQREWEALCRYE-AEPSAREAASQPQCAG--------- 987
              .|.:..:....:|.|     .|.....|:.::|.::: :|.||..:.|....:|
  Fly   432 QNKTCVQCAVKSAILPY-----SNCATCSRKSDSLSKHKRSESSASSSPSSGSGSGPGSSGTSGV 491

  Fly   988 --LNRPGAPLPYDHSR------VVLNHLANAEGLDYVNASTITDHDPRA--PAYVAAQGPL---- 1038
              :|.||.|.......      ::..|..::.|...::.:.......|.  ..|:|.||.|
  Fly   492 SSVNGPGTPTNLTSGTAGCLVGLLKRHSNDSSGAVSISMAEREREREREMFKTYIATQGCLLTQQ 556

  Fly  1039 PSTLAHFWQMIWEQGAVVIVALCRLQENGEVACARYWPEEG-AEVYHIYEVHLVSEHIWCDDYLV 1102
            .:|:..||.|:|::...|||...:..|.|:..||||||:|| :|.:....:..|||:. ..||.:
  Fly   557 VNTVTDFWNMVWQENTRVIVMTTKEYERGKEKCARYWPDEGRSEQFGHARIQCVSENS-TSDYTL 620

  Fly  1103 RSFYLKNLRTSETRTVTQFHFLSWPHMGVPAQAKALLDFRRKVNK-----SYRGRRSCPIVVHGS 1162
            |.| |.:.|....|.:..:||..||..||||....:|:|.:.||.     :..|.:..||.||.|
  Fly   621 REF-LVSWRDQPARRIFHYHFQVWPDHGVPADPGCVLNFLQDVNTRQSHLAQAGEKPGPICVHCS 684

  Fly  1163 AGAGRTGVYILLDLVLERMNKGA--REIDIAATLEHLRDQRAGVVATRQQFEFVLMAVAEEVHAI 1225
            ||.||||.:|::|::|:::.:..  .||||..|::.:|.||:|:|.|..|::||..||...:..:
  Fly   685 AGIGRTGTFIVIDMILDQIVRNGLDTEIDIQRTIQMVRSQRSGLVQTEAQYKFVYYAVQHYIQTL 749

  Fly  1226 LKALPANTSGEKR---------------ELDKD------PVVGGGSSSTTTKEPLKEDKA----- 1264
            :    |....|::               |:..|      |......|...:|.||....|
  Fly   750 I----ARKRAEEQSLQVGREYTNIKYTGEIGNDSQRSPLPPAISSISLVPSKTPLTPTSADLGTG 810

  Fly  1265 -------------QEAAEEEAP--------------------------TSSSKAAA--------- 1281
                         :.|::::.|                          ||||..::
  Fly   811 MGLSMGVGMGVGNKHASKQQPPLPVVNCNNNNNGIGNSGCSNGGGSSTTSSSNGSSNGNINALLG 875

  Fly  1282 ---------AAKKEKEKDKDKEEKQAKDQA-----KVAEPRTPAK 1312
                     ..|.....|..|:::|.::||     |:.:|..|.:
  Fly   876 GIGLGLGGNMRKSNFYSDSLKQQQQREEQAPAGAGKMQQPAPPLR 920

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
IA-2	NP_608562.4	Receptor_IA-2	708..795	CDD:288410	19/89 (21%)
		PTPc	960..1220	CDD:214550	91/291 (31%)
		PTPc	995..1220	CDD:238006	80/244 (33%)
csw	NP_477131.1	SH2_C-SH2_SHP_like	211..307	CDD:198185	22/119 (18%)
		PTPc	326..744	CDD:214550	121/474 (26%)
		PTPc	543..743	CDD:238006	76/201 (38%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45443530
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.840