Protein Alignment IA-2 and Ptp69D

DIOPT Version :10

• Sequence 1: NP_608562.4
• Gene: IA-2 / 33277
• FlyBaseID: FBgn0031294
• Length: 1319
• Species: Drosophila melanogaster
• Sequence 2: NP_524048.2
• Gene: Ptp69D / 39443
• FlyBaseID: FBgn0014007
• Length: 1462
• Species: Drosophila melanogaster
• Alignment Length: 1246
• Identity: 247/1246 - (19%)
• Similarity: 434/1246 - (34%)
• Gaps: 395/1246 - (31%)

  Fly   178 CQFVRTLCIPHSE-------------------VCYDDNIFGKCIPTTGVDVE---DIEKTP---- 216
            |..:...|.|.||                   .|:.||:      |.|..:.   |:.|||
  Fly   414 CSDLTKTCGPWSENVNGTTMDGVATKPTNLSIQCHHDNV------TRGNSIAINWDVPKTPNGKV 472

  Fly   217 ---LTEDQSRVLATMLEELQGAGL-GWDHPYVQCRIQGSLFSLQRQQQLPPNLCANLAPTPPEF- 276
               |.......::|:..|:.|..: ..|.|:     ..:|:     :.:.||  .|...|....
  Fly   473 VSYLIHLLGNPMSTVDREMWGPKIRRIDEPH-----HKTLY-----ESVSPN--TNYTVTVSAIT 525

  Fly   277 -----GDPASALAYVRFTPPE-------PEAELDYYEQPAGPAQFYPALRKKQVRESDAD----D 325
                 |:||:....:..:.|:       .:..||        :::...|...::.|.:..    .
  Fly   526 RHKKNGEPATGSCLMPVSTPDAIGRTMWSKVNLD--------SKYVLKLYLPKISERNGPICCYR 582

  Fly   326 MYLNRMLQDRRRLRHDPSELEHFGKMDGHGQSTQLDAPSIM----------DAFLDTERQRIERE 380
            :||.|:..|.:.| .||.:|......:.|..:....:..|.          :.||..|: |....
  Fly   583 LYLVRINNDNKEL-PDPEKLNIATYQEVHSDNVTRSSAYIAEMISSKYFRPEIFLGDEK-RFSEN 645

  Fly   381 QQLAAAEQDADRRAEQNRLELYQILAASEPDPQPYQRKPAAQPNAMDQLEAIVEQQQQRELKEQQ 445
            ..:.....:..|:..:.               .|:.|||..
  Fly   646 NDIIRDNDEICRKCLEG---------------TPFLRKPEI------------------------ 671

  Fly   446 EQAKAPVYVPPEE--VNESSELYFPDNFAPFKRARGRSRGGLAEEVEDEQPKRSFFRELAGEQGL 508
                  :::||:.  .|..|||       |.          |:|  :|...|.:...|.|.:
  Fly   672 ------IHIPPQGSLSNSDSEL-------PI----------LSE--KDNLIKGANLTEHALK--- 708

  Fly   509 VQEPPLRFRHVETEVDATPELVKRRP-----ASFKQLDPYDVSLQQQEMAFESGLLRNS------ 562
            :.|..||.:......|..|.|....|     .|.:.:...::.:......|...::|:.
  Fly   709 ILESKLRDKRNAVTSDENPILSAVNPNVPLHDSSRDVFDGEIDINSNYTGFLEIIVRDRNNALMA 773

  Fly   563 -------LTPLEEEAMLASNSFPRQAKSQRVY-----TEGGLLLMP-----------QDEQDTDG 604
                   :||       |:.:.|.|:.:...|     .:.|.:|:.           ..::..:.
  Fly   774 YSKYFDIITP-------ATEAEPIQSLNNMDYYLSIGVKAGAVLLGVILVFIVLWVFHHKKTKNE 831

  Fly   605 MQADEPENVKQSLLANMLG-----------FARHERLDVKKPGPLLGPPSLGSAELSNQLETEKA 658
            :|.::...::.||...:.|           ...|:..|.   ||:            ::|:.|.|
  Fly   832 LQGEDTLTLRDSLSRALFGRRNHNHSHFITSGNHKGFDA---GPI------------HRLDLENA 881

  Fly   659 ----HKQKGHG---NKEVLPAHIKGNDEDDAHKKKKVMKQQH---SAEDHAPHTV-------DTE 706
                ||...:|   ..|:||.........::..|:...|.::   .|.|.....:       .|:
  Fly   882 YKNRHKDTDYGFLREYEMLPNRFSDRTTKNSDLKENACKNRYPDIKAYDQTRVKLAVINGLQTTD 946

  Fly   707 YVH-------------VFVKNPIDSW-NDGQRIMKE--LEQILHMQGYFSYL------------- 742
            |::             :..:.|::|. :|..|::.|  ||.|:.:.....|.
  Fly   947 YINANFVIGYKERKKFICAQGPMESTIDDFWRMIWEQHLEIIVMLTNLEEYNKAKCAKYWPEKVF 1011

  Fly   743 -TVQQHEVSFRVNSNNPERKTAGDVARTIN-----ENRGVKNNIQRRVGFYVLHAGVGDVIKDLQ 801
             |.|..::..:...   ||||...:.||:|     .|.|.:.:.::...::.|      ..||..
  Fly  1012 DTKQFGDILVKFAQ---ERKTGDYIERTLNVSKNKANVGEEEDRRQITQYHYL------TWKDFM 1067

  Fly   802 DPSVSSSRIELAEQ---------GPDVTHIMAYMFAGAGAAAVIVIFVTLI-LIKRHD------- 849
            .|......|:...|         ||    |:.:..||.|....:|...:|| .::..|
  Fly  1068 APEHPHGIIKFIRQINSVYSLQRGP----ILVHCSAGVGRTGTLVALDSLIQQLEEEDSVSIYNT 1128

  Fly   850 -----RKRDKLGGLQSGIAGAETCSKDYQELCRARMAGKAGGGGNS-----TGGAAGGGSNEPAP 904
                 .:|:.|  :||        .|.|..|.||.:  ..|..||:     |..:|
  Fly  1129 VCDLRHQRNFL--VQS--------LKQYIFLYRALL--DTGTFGNTDICIDTMASA--------- 1172

  Fly   905 SGRITSLS-KENEGRPPSSRSSTSSWSEEPALTNMDISTGHMVLSYMEDHLRNKGRLQREWEALC 968
               |.||. |.|||                                       |.:|:.|:|.|.
  Fly  1173 ---IESLKRKPNEG---------------------------------------KCKLEVEFEKLL 1195

  Fly   969 RYEAEPSAREAASQPQCAGL-NRPGAPLPYDHSRVVLNHLANAEGLDYVNASTITDHDPRAPAYV 1032
            ....|.|...:..:.:...: ||....:|||.:||:|..|...|...|:|||.|..:| .:..::
  Fly  1196 ATADEISKSCSVGENEENNMKNRSQEIIPYDRNRVILTPLPMRENSTYINASFIEGYD-NSETFI 1259

  Fly  1033 AAQGPLPSTLAHFWQMIWEQGAVVIVALCRLQENGEVACARYWPEEGAEVYHIYEVHLVSEHIWC 1097
            .||.||.:|:..||:||.||....:|.:..:.: |...|.|||.::..:..||...::.||.  |
  Fly  1260 IAQDPLENTIGDFWRMISEQSVTTLVMISEIGD-GPRKCPRYWADDEVQYDHILVKYVHSES--C 1321

  Fly  1098 DDYLVRSFYLKNLRTSETRTVTQFHFLSWPHMG--VPAQAKALLDFRRKVNKSYRGRRS--C--P 1156
            ..|..|.||:.|.:..:|..||||.:..||.:.  ||...:.:::...:....|:..::  |  |
  Fly  1322 PYYTRREFYVTNCKIDDTLKVTQFQYNGWPTVDGEVPEVCRGIIELVDQAYNHYKNNKNSGCRSP 1386

  Fly  1157 IVVHGSAGAGRTGVYILLDLVLE--RMNKGAREIDIAATLEHLRDQRAGVVATRQQFEFVLMAVA 1219
            :.||.|.|..|:.:::.:.::::  |:.|.   :||.||...||.||.|::.:..|:||:..|:.
  Fly  1387 LTVHCSLGTDRSSIFVAMCILVQHLRLEKC---VDICATTRKLRSQRTGLINSYAQYEFLHRAII 1448

  Fly  1220 --EEVHAILKA 1228
              .::|.|.::
  Fly  1449 NYSDLHHIAES 1459

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
IA-2	NP_608562.4	Receptor_IA-2	705..795	CDD:463293	23/124 (19%)
		PTP_DSP_cys	942..1225	CDD:475123	83/293 (28%)
Ptp69D	NP_524048.2	Ig_3	35..114	CDD:464046
		Ig_3	134..216	CDD:464046
		fn3	237..321	CDD:394996
		FN3	<300..>524	CDD:442628	25/127 (20%)
		PTPc	892..1155	CDD:214550	55/287 (19%)
		PTPc	1186..1449	CDD:214550	81/269 (30%)