Protein Alignment IA-2 and PTP-ER

DIOPT Version :10

• Sequence 1: NP_608562.4
• Gene: IA-2 / 33277
• FlyBaseID: FBgn0031294
• Length: 1319
• Species: Drosophila melanogaster
• Sequence 2: NP_726092.1
• Gene: PTP-ER / 37461
• FlyBaseID: FBgn0016641
• Length: 1377
• Species: Drosophila melanogaster
• Alignment Length: 1604
• Identity: 270/1604 - (16%)
• Similarity: 447/1604 - (27%)
• Gaps: 662/1604 - (41%)

  Fly    23 QHPCTTTEEPKHQRARGTAGHQESATGECQQFWSKQRP---PFDQQQ------------------ 66
            ::|...|..|.|.....|...:.....|.    :|..|   |.:..|
  Fly    15 EYPYPQTPRPTHAAPSDTTPLEAGEDAES----NKSTPYFTPLEYLQTSFEFPSPTVEVGGGVPG 75

  Fly    67 --QQEDQDPEQ-DPQQHPST-PQESVH-HHRSPRQHELLHHQRKVPPTLPARGRHLISEGARRRE 126
              :.|||:.|. .|:|...| |..:.| ||.|..|          .|||..:.:.|
  Fly    76 FPEHEDQEEEVFTPRQFTITSPHPAAHVHHPSSSQ----------SPTLGRKFKRL--------- 121

  Fly   127 VRGCGAGGGGLLCCSLDALSRPAKLLQFGVLLLILLLATHGDLAQAEGNVGCQFVRTLCIPHSEV 191
                                                               .|:.|..|.||...
  Fly   122 ---------------------------------------------------SQYDRRSCSPHINT 135

  Fly   192 CY-DDNIFGKCIPTTGVDVEDIEKTPLTEDQSRVLATMLEELQGAGLGWDHPYVQCRIQGSLFSL 255
            .. ::.:.|:     |:|.|:               ||   .:|..:..|       ::.||:..
  Fly   136 SSGEERVSGR-----GIDKEN---------------TM---PKGGSVDQD-------LENSLYLS 170

  Fly   256 QRQQQLPPNLCANLAPTPPEFGDPASALAYVRFTPPEPEAELDYYEQPAGPAQFYPALRKKQVRE 320
            :.:...|..|..:.:.|.|  |..||.|:|    .|:..:.::.......|.....:...|.
  Fly   171 KSEHNSPTILFKDESSTTP--GLEASRLSY----SPKLLSSINNLNVSGSPLNIINSAGYKN--- 226

  Fly   321 SDADDMYLNRMLQDRRRLRHDPSELEHFGKMDGHGQSTQLDAPSIMDAFLDTERQRIER-----E 380
                                  .....|.::|...|...:|...:.:|   |.|.|...     |
  Fly   227 ----------------------GNFFRFPEIDHVVQDAPMDTVCLEEA---TRRDRSPALAEPPE 266

  Fly   381 QQLAAAEQDADRRAEQN---RLELYQILAASEPDPQPYQRKPAAQPNAMDQLEAIVEQQQQRELK 442
            ||...:|...:|:.:.|   |:....|..:|:|.|.|..:.|..:..          :::.|.|.
  Fly   267 QQQQKSEGRKNRKNKNNLTIRITDVPIKNSSQPSPLPKPKTPTIKST----------KEKARSLD 321

  Fly   443 EQQEQAKAPVYVPPEEVNESSELYFPDNFAPFKRARGRSRGGLAEEVEDEQPKRSFFRELAGEQG 507
            ....:::..:.|  ..:.||.                    |..:::|..|
  Fly   322 SAANESELSIVV--HNITESH--------------------GSCDDMETGQ-------------- 350

  Fly   508 LVQEPPLRFRHVETEVDATPELVKRRPASFKQLDPYDVSLQQQEMAFESGLLRNSLTPLEEEAML 572
              .:|.....|                        :.:.|||...|..|    .||:.|:....|
  Fly   351 --SQPSTSVIH------------------------HHLHLQQPASAIHS----TSLSRLDSHLSL 385

  Fly   573 ASNSFPRQAKSQRVYTEGGLLLMPQDEQDTDGMQADEPENVKQSLLANMLGFARHERLDVKKPGP 637
            |:.....:.||..:.|..  .||...:|:...:|.....:..||.|.:.....
  Fly   386 ANQRRTPRRKSPGINTTD--WLMYHRKQNPYQVQPTHCSSTTQSSLDSDASLT------------ 436

  Fly   638 LLGPPSLGSAELSN--------------QLETEKAHK--QKGHG---NKEVLPAHIK-------- 675
                ||||..||.:              .|....|||  |..|.   |.:.||..:.
  Fly   437 ----PSLGDFELKSACSVDGGSKFGIGASLAPRSAHKHNQLLHSSSTNLKTLPECLTLVEFSSSG 497

  Fly   676 GNDEDDAHKKKKVMKQQHSAEDHAPHTVDTEYV---------HVFVKNPIDS----WNDG-QRIM 726
            |..::...|:|.:.....:.:  |..||.|..:         |....|...|    .|.| ....
  Fly   498 GGPKESPFKQKSMDLPMPTLQ--AKTTVSTSSMNLLQRRGSNHSLTLNLHSSCGNLMNSGLSHSN 560

  Fly   727 KELEQILHMQ-------GYFSYLTVQQHEVSFRVNSNNPERKTAGDVARTINENRGVKNNIQRRV 784
            ..|..||:.:       |..|.:...|...|..:.|:...|       :.:...||..::|..:.
  Fly   561 YSLGSILNSKSSCNLDAGTASQIRADQLPQSHLLGSSQGSR-------QGLFRRRGSNHSITLKT 618

  Fly   785 GFYVLHAGVGDVIKDLQDPS--VSSSRIELAEQGPDVTHIMAYMFAGAGAAAVIVIFVTLILIKR 847
            |......|..:.::.||...  :|:.:........:.|.      :|:|:.:.:......:|.:|
  Fly   619 GHTTTSCGDLNSMQQLQQQQAMLSAEKYNRLNMRTNSTG------SGSGSGSNVPTPKRGLLERR 677

  Fly   848 HDRKRDKL--GGLQSGIAGAETCSKDYQE----LCRARMAGKA-------------GGGGNST-- 891
            ...:...|  |.:..|.||.|....|..:    :|....|.:|             ....||.
  Fly   678 GSNQSLTLNMGSILGGAAGTEIQMTDIVQPKVTVCSCAAANQAPHQRKFFSTENLNSSKANSQKF 742

  Fly   892 -GGAAGGGSNEPAPSGRITSLSKENEG----------------RPPSSRSSTSSW---------- 929
             |....|.:::..|:.:..|: :|::.                ||.|.::::..:
  Fly   743 FGQVCFGSASDLQPNPQQDSV-REDQAIGATCTCAGTVRNIMTRPLSPQTTSEEFKIYLASIQML 806

  Fly   930 -SEEPALTNMDISTGHMVLSYMEDHLRNKGR-------------------------LQREWEALC 968
             |....|...|:    :.|:|:.||.....|                         ...:.|.|.
  Fly   807 QSASNPLNQFDL----IRLNYVFDHSYQTNRNIIEQPPVLGSNARDVETPTDMVPPSSEDSELLA 867

  Fly   969 RYEAE--------PSARE--------------------AASQPQCAG---LNRPGAPLPYDHSRV 1002
            .|:..        |..:|                    ...:|...|   .||....||.::|||
  Fly   868 SYQTVVSRMAQPIPELKENEQKRIFRDLHKEFWDLPLNHQEKPMVFGSQTKNRYKTILPNENSRV 932

  Fly  1003 VL-----------------NHLANAEGLDYVNASTITDHDPRAPAYVAAQGPLPSTLAHFWQMIW 1050
            :|                 :.:..:|.|.|:||:.|...|..:..|||.|||||:|:..||.||:
  Fly   933 LLESESSELTSLLGEIKRTSSVTASEDLPYINANYIKGPDYVSKCYVATQGPLPNTIFEFWLMIY 997

  Fly  1051 ---------------------------EQGAVVIVALCRLQENGEVACARYWPEEGAEVYHI--- 1085
                                       :|....||.|....|.....||.|:|.|..|::.:
  Fly   998 QNTQRYIRRCVDGGSSSSPHVDREQILQQYFQKIVMLTNFTEANRQKCAVYFPIELNEIFAVAAK 1062

  Fly  1086 -----------------------------------YEVHLVSEHIWCDDYLVR------------ 1103
                                               ||:.  ..||..:...|.
  Fly  1063 CEVFQLSAAARDYFDRYLTPTFVPDTVVASSDAIDYEIS--GRHIGVESVKVTLEGDLLEALPAQ 1125

  Fly  1104 -SFYL-KN-------------------LRTSET-----RTVTQFHFL--SWPHMGVPAQAKALLD 1140
             ||:| ||                   :|..::     :.:..:|:.  .||....|.....|||
  Fly  1126 GSFFLIKNVGIVRRNGYSVRKLVLLYCIRVPQSASYHLQKIYCYHYWYPDWPDHHSPRDINTLLD 1190

  Fly  1141 ------------FRRKVNKSYRGRRSCPI--------------------VVHGSAGAGRTG---- 1169
                        ....:....|..|:..:                    |:|.|||.||||
  Fly  1191 TCLHVLNLGKCESEFDIYDDTRSERNAHLAAQRLEIYQQDIFNAVQPLPVIHCSAGIGRTGCFTA 1255

  Fly  1170 ------------VYILLDLVLERMNKGARE----------------------------------- 1187
                        .|.|..::.:.:...:.|
  Fly  1256 ILNAVRQLRQSLAYSLTGMLTKSLTSSSTEEYHNPTDSDSSFTCNTIRHISHILDHRDAEAVKTP 1320

  Fly  1188 -------------IDIAATLEHLRDQRAGVVATRQQFEFVLMAV 1218
                         :|:...:.:||.||.|:|...:|:|.:..|:
  Fly  1321 PSFDRLPKMPDIFVDVLGIVCNLRLQRGGMVQNSEQYELIHRAI 1364

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
IA-2	NP_608562.4	Receptor_IA-2	705..795	CDD:463293	20/110 (18%)
		PTP_DSP_cys	942..1225	CDD:475123	93/551 (17%)
PTP-ER	NP_726092.1	PTP_DSP_cys	919..1362	CDD:475123	80/444 (18%)