DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment IA-2 and Ptp52F

DIOPT Version :9

Sequence 1:	NP_608562.4	Gene:	IA-2 / 33277	FlyBaseID:	FBgn0031294	Length:	1319	Species:	Drosophila melanogaster
Sequence 2:	NP_611093.2	Gene:	Ptp52F / 36790	FlyBaseID:	FBgn0034085	Length:	1433	Species:	Drosophila melanogaster

Alignment Length:	798	Identity:	186/798 - (23%)
Similarity:	297/798 - (37%)	Gaps:	233/798 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly   551 EMAFESGLLRNSLTPLEEEAMLASNSFPRQAKSQRVYTEGGLLLMPQDEQDTDGMQADEPENVKQ 615
            ::||..  .||:..|:..|..:..::..:|.:.....||    :.||.:...:       .:||.
  Fly   796 QLAFNG--TRNNFAPVSFERRVELDTGNKQGRMSYTETE----MQPQFDYTVE-------VSVKN 847

  Fly   616 SLLANMLGFARHERLDVKKPGPLLGP---PSLGSAELSNQLETEKAHKQKGHGNKEV---LPAHI 674
            ..:         |:|....||....|   |::.|.||..|:....  ::..:..|..   |||.|
  Fly   848 RDV---------EQLSSSVPGSWQSPAGLPTIPSDELIKQMRANV--EETSNPTKTAIVRLPADI 901

  Fly   675 KGNDEDDAHKKKKVMKQQHSA-EDHAPHTVDTEYVHV--FVKNPIDSWNDGQRIMKELEQILHMQ 736
            ..:...|......::.|::.| ..|..:.|.:::..|  :.:...|...|.....:..|:..|.:
  Fly   902 MTSASGDIKWMALMISQKNCAGVPHLKYDVSSDWPKVLSYQEAGADGTGDCSLEYQTTEERWHPE 966

  Fly   737 GYFSYLTVQQHEVSFRVNSNNPERKTAGDVARTINENRGVKNNIQRRVGFYVLHAGVGDVIKDLQ 801
                  .||:......|.|:.       ::..||                     |: |...::|
  Fly   967 ------PVQRQRRDGEVTSDE-------EIVFTI---------------------GL-DKCSEVQ 996

  Fly   802 DPSVSSSRIELAEQGPDVTH-IMAYMFAGAG--AAAVI------VIFVTLILIKRHDRKRDKLGG 857
            ....:...:      ||..: ::..:|..:|  .|||:      .|.|||||:
  Fly   997 KTYCNGPLL------PDTDYNVVVRLFTASGYSDAAVLNFKTKAAIKVTLILV------------ 1043

  Fly   858 LQSGIAGAETCSKDYQELC--------------RARMAGKAGGGGNSTGGAAGGGSNEPAPSGRI 908
                    ..||      |              |.|:|.|..         :|.|..:|..
  Fly  1044 --------SVCS------CLLLAFVLGLTVLWVRKRLAWKRD---------SGQGIEDPFG---- 1081

  Fly   909 TSLSKENEGRPPSSRSSTSSWSEEPALTNMDISTGHMVLSYMEDHLRNKGRLQREWEALCRYEAE 973
                                          ::...:..:.|.|  :....:|.||::.:.....|
  Fly  1082 ------------------------------NVIAKNFAIFYTE--VAKPEKLAREFKEITVVALE 1114

  Fly   974 PSAREAASQPQCAGLNRPGAPLPYDHSRVVLNHLANAEGLDYVNASTITDHDPRAPAYVAAQGPL 1038
            .|  .:||:..| ..||.....|||.:||:|:  .:|||.||:|||.|..| .|...|:|.|||.
  Fly  1115 LS--YSASELGC-HKNRYADIFPYDKNRVILD--IDAEGSDYINASFIDGH-TRKKEYIATQGPK 1173

  Fly  1039 PSTLAHFWQMIWEQGAVVIVALCRLQENGEVACARYWPE---------EGAEVYHIYE-VHLVSE 1093
            |.::..||:||.:....|||.:.:.:|...:.|..|:|.         :..||..:|: ..|...
  Fly  1174 PESVMDFWRMILQYNVRVIVQVTQFREGNTIKCHEYYPYNVRGLTVTIKSKEVLELYDRTELTVV 1238

  Fly  1094 HIWCDDYLVRSFYLKNLRTSETRTVTQFHFLSWPHMGVPAQAKALLDFRRKVNKSYRGRRSCPIV 1158
            |   |.|.::            ..|..::|..||..|||.....|:.|.:||....|...| |||
  Fly  1239 H---DKYGLK------------EKVIHYYFKKWPDHGVPEDPMHLIMFVKKVKAEKRPSYS-PIV 1287

  Fly  1159 VHGSAGAGRTGVYILLDLVLERMNKGAREIDIAATLEHLRDQRAGVVATRQQFEFVLMAVAEEV- 1222
            ||.|||.||||.:|.|||:::|: |...:|:|..|::.||.||..:|.|:||:.|:.....|.|
  Fly  1288 VHCSAGVGRTGTFIGLDLIMQRL-KSESKINIFETVKKLRFQRMKMVQTQQQYTFLYACTYELVK 1351

  Fly  1223 HAILKA------------LPANTSGEKRELDKDPVVGGGSSSTTTK--------EPLKE------ 1261
            |.|.:|            :||..|.:|...   |.|..||...::.        .|:.:
  Fly  1352 HKIPRAALKMDGRPKSVTVPAIPSPKKVSF---PDVDVGSEYVSSAPITDLDDGRPIVQLPSRFS 1413

  Fly  1262 --DKAQEAAEEEAPTSSS 1277
              .:.....|.:.|||||
  Fly  1414 GLRRNSPPGENDNPTSSS 1431

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
IA-2	NP_608562.4	Receptor_IA-2	708..795	CDD:288410	12/88 (14%)
		PTPc	960..1220	CDD:214550	94/269 (35%)
		PTPc	995..1220	CDD:238006	84/234 (36%)
Ptp52F	NP_611093.2	FN3	648..749	CDD:238020
		PTPc	1100..1345	CDD:214550	94/267 (35%)
		PTPc	1125..1348	CDD:238006	86/242 (36%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45443534
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm46470
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	2.840