Protein Alignment IA-2 and Ptprt

DIOPT Version :10

• Sequence 1: NP_608562.4
• Gene: IA-2 / 33277
• FlyBaseID: FBgn0031294
• Length: 1319
• Species: Drosophila melanogaster
• Sequence 2: XP_063140269.1
• Gene: Ptprt / 362263
• RGDID: 1309653
• Length: 1487
• Species: Rattus norvegicus
• Alignment Length: 886
• Identity: 215/886 - (24%)
• Similarity: 329/886 - (37%)
• Gaps: 227/886 - (25%)

  Fly   436 QQQRELKEQQEQAKAPVYVPPEEVNESSELYFPDNFAPFKRAR---------GRSRG-GLAEEVE 490
            |.|....:||.:|        |||.::|..|......||...|         ||... .|..:.|
  Rat   429 QYQYVFNQQQYEA--------EEVIQTSSHYTLRGLRPFMTIRLRLLLSNPEGRMESEELVVQTE 485

  Fly   491 DEQPKRSFFRELAG----EQGLVQ-EPPLRFRHVET----------EVDATPELVKRRPASFKQL 540
            ::.|.......:.|    |:..:| :||.....|.|          .:|.:.:|..:|...||
  Rat   486 EDVPGAVPLESIQGGPFEEKIYIQWKPPNETNGVITLYEINYKAVGSLDPSADLSSQRGKVFK-- 548

  Fly   541 DPYDVSLQQQEMAFESGLLRNSLTPLEEEAMLASNSFPRQAKSQRVYTEGGLLLMPQDEQDTDGM 605
                  |:.:......||...:......:|..|....|  ..:.|:.|:.....||:       .
  Rat   549 ------LRNETHHLFVGLYPGTTYSFTIKASTAKGFGP--PVTTRIATKISAPSMPE-------Y 598

  Fly   606 QADEPENVKQSLLANMLGFARHERLDVKKPGPLLGPP-SLGSAELSNQLETEKAHKQKGHGNKEV 669
            .||.|.|...:.:..||           ||....|.| |:      .||..::...||.....::
  Rat   599 DADSPLNETDTTITVML-----------KPAQSRGAPVSV------YQLVVKEERLQKSRRAADI 646

  Fly   670 LP------AHIKGNDEDDAHKKKKVMKQQHSAEDHAPHTV-DTEYVHVFVKNPIDSWNDGQRIMK 727
            :.      ::...::.|..|.....:|..:..... |.|| |.:..:.:       ||      .
  Rat   647 IECFSVPVSYRNASNLDSLHYFAAELKPSNLPVTQ-PFTVGDNKTYNGY-------WN------P 697

  Fly   728 ELEQILHMQGYFSYLTVQQHEVSF---RVNSNNP---ERKTAGDVARTINENRGVKNNIQRRVGF 786
            .|..:.....||..|:....|...   |:.:..|   .:.|.|.....:......:|
  Rat   698 PLSPLKSYSIYFQALSKANGETKINCVRLATKAPMGSAQVTPGTPLCLLTTGASTQN-------- 754

  Fly   787 YVLHAGVGDVIKDLQDPSVSSSRIELAEQGPDVTHIMAYMFAGAGAAAVIVIFVTLILIKRHD-- 849
                                |:.:| .|:..|.|..||.:.||.....:|::.|.|.:.:|.:
  Rat   755 --------------------SNTVE-PEKQVDNTVKMAGVIAGLLMFIIILLGVMLTIKRRRNAY 798

  Fly   850 -------------RKRDKLGGLQSGIAGAETCSKDYQELCRARMAGKAGGGGNSTGGAAGGGSNE 901
                         ::::...|.|..:....:..|...:|...|         |..|
  Rat   799 SYSYYLSQRKLAKKQKETQSGAQREMGPVASTDKPTTKLSTNR---------NDEG--------- 845

  Fly   902 PAPSGRITSLSKENEGRPPSSRSSTSSWSEEPALTNMDISTGH-------MVLSYMED------- 952
                  .:|.|::..|....||...|    :|.||   |.| |       :.:||..|
  Rat   846 ------FSSSSQDVNGFTDGSRGELS----QPTLT---IQT-HPYRTCDPVEMSYPRDQFQPAIR 896

  Fly   953 ------HLRNKGR-----LQREWEALCRYEAEPSAREAASQPQCAGLNRPGAPLPYDHSRVVLNH 1006
                  |:....|     .:.|:|||  .|.:.::.:.|.:.:....||.|..:.||||||.|..
  Rat   897 VADLLQHITQMKRGQGYGFKEEYEAL--PEGQTASWDTAKEDENRNKNRYGNIISYDHSRVRLLV 959

  Fly  1007 LANAEGLDYVNASTITD-HDPRAPAYVAAQGPLPSTLAHFWQMIWEQGAVVIVALCRLQENGE-- 1068
            |......||:||:.|.. |.||  .|:|.|||:..|:..||:|||::.:..||.:..|.|.|.
  Rat   960 LDGDPHSDYINANYIDGYHRPR--HYIATQGPMQETVKDFWRMIWQENSASIVMVTNLVEVGRHP 1022

  Fly  1069 ------------------VACARYWPEEGAEVYHIYEVHLVSEHIWCDDYLVRSFYLKNLRTSET 1115
                              |.|.||||:: .|||...:|.|:...... :|::|:|.::.....|.
  Rat  1023 AEHTVGTATLGRAASPGMVKCVRYWPDD-TEVYGDIKVTLIETEPLA-EYVIRTFTVQKKGYHEI 1085

  Fly  1116 RTVTQFHFLSWPHMGVPAQAKALLDFRRKVNKSYRGRRSCPIVVHGSAGAGRTGVYILLDLVLER 1180
            |.:..|||.|||..|||..|..||.|.|:| |......:.|||||.||||||||.:|.:|.:|:.
  Rat  1086 RELRLFHFTSWPDHGVPCYATGLLGFVRQV-KFLNPPEAGPIVVHCSAGAGRTGCFIAIDTMLDM 1149

  Fly  1181 M-NKGAREIDIAATLEHLRDQRAGVVATRQQFEFVLMAVAE 1220
            . |:|.  :||...:..||.||..:|.|.:|:.||..|:.|
  Rat  1150 AENEGV--VDIFNCVRELRAQRVNLVQTEEQYVFVHDAILE 1188

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
IA-2	NP_608562.4	Receptor_IA-2	705..795	CDD:463293	12/95 (13%)
		PTP_DSP_cys	942..1225	CDD:475123	111/326 (34%)
Ptprt	XP_063140269.1	None