Protein Alignment IA-2 and Ptprf

DIOPT Version :10

• Sequence 1: NP_608562.4
• Gene: IA-2 / 33277
• FlyBaseID: FBgn0031294
• Length: 1319
• Species: Drosophila melanogaster
• Sequence 2: XP_038966082.1
• Gene: Ptprf / 360406
• RGDID: 3453
• Length: 1924
• Species: Rattus norvegicus
• Alignment Length: 907
• Identity: 214/907 - (23%)
• Similarity: 342/907 - (37%)
• Gaps: 247/907 - (27%)

  Fly   415 YQRKPAAQPNAMDQLEAIVEQQQQRELKEQQEQAKAPVYVPPEEVNESSELYFPDNFAPFKRARG 479
            |:|...|:||.:|                   ..|...:.....:::.:...|        |...
  Rat   863 YRRADEARPNTID-------------------FGKDDQHFTVTGLHKGATYIF--------RLAA 900

  Fly   480 RSRGGLAEEVEDE----QPKRSFFRELAGEQGLVQ-------EPPL---------RFRHVETEVD 524
            ::|.|..||.|.|    :...|.|.:.....||..       :||:         .:..|..:::
  Rat   901 KNRAGPGEEFEKEITTPEDAPSGFPQNLRVTGLTTSTTELAWDPPVLAERNGRITNYTVVYRDIN 965

  Fly   525 ATPEL---------------------VKRRPASFKQLDPYDVSLQQQEMAFESGLLRN-SLTPLE 567
            :..||                     :|.|..:.|...|...|:|.|.|..|....:| .:....
  Rat   966 SQHELQNVTGDVHLTLLGLKPDTTYDIKVRAHTSKGAGPLSPSIQSQTMPMEQVFAKNFRVAAAM 1030

  Fly   568 EEAMLASNSFPRQAKSQRVYTEGGLLLMPQDEQDTDG-----MQADEPENVKQSLLANMLGFARH 627
            :.::|.|...|...||...:.    :|......:.||     :.||...|.:.|.:....|
  Rat  1031 KTSVLLSWEVPDSYKSAVPFK----ILYNGQSVEVDGHSMRKLIADLQPNTEYSFVLMNRG---- 1087

  Fly   628 ERLDVKKPGPLLGPPSLGSAELSNQLETEKAHKQKGHGNKEVLPAHIKGNDEDDAHKKKKVMKQQ 692
                          .|.|..:....:.|.          .::||              :|.:...
  Rat  1088 --------------SSAGGLQHLVSIRTA----------PDLLP--------------QKPLPAS 1114

  Fly   693 HSAED-----HAPHTVDTEYVHVF--VKNPID---------SWNDGQRIMKELEQILHMQGYFSY 741
            ...||     ..|...|...|..|  |..|||         .|:..:.:  ||:::|.
  Rat  1115 AFIEDGRFSLSMPQVQDPSLVRWFYIVVVPIDRVGGNLLAPRWSTPEEL--ELDELLE------- 1170

  Fly   742 LTVQQHEVSFRVNSNNPERKTAGDVARTINE-----NRGVKNNIQRRVGFY--VLHAGVG---DV 796
             .::|.|...|......|| ....||..::|     ..|.|.|.:   |||  .|...:.   .|
  Rat  1171 -AIEQGEEKQRRRRRQAER-LKPYVAAQVDELPETFTLGDKKNYR---GFYNRPLSPDLSYQCFV 1230

  Fly   797 IKDLQDP--------SVSSSRIEL------AEQGPDVTHIMAYMFAGAGAAAVIVIFVTLILIKR 847
            :..|::|        |..|..|.:      .::.|::      ::......|||:|.:.:|.|..
  Rat  1231 LASLKEPMDQKRYASSPYSDEIVVQVTPAQQQEEPEM------LWVTGPVLAVILIILIVIAILL 1289

  Fly   848 HDRKRDKLGGLQSGIAGAETCSKDYQELCRARMAGKAGGGGNSTGGAAGGGSNEPAPSGRITSLS 912
            ..|||..           ...|||.|.:              ....:....|::|....|   |:
  Rat  1290 FKRKRTH-----------SPSSKDEQSI--------------GLKDSLLAHSSDPVEMRR---LN 1326

  Fly   913 KENEGRPPSSRSSTSSWSEEPALTNMDISTGHMVLSYMEDHLRNKG-RLQREWEALCRYEAEP-- 974
            .:..|....|..:.||..:.|.:...|::..      :|....|.| :..:|:|::     :|
  Rat  1327 YQTPGSSAPSCPNISSMRDHPPIPITDLADN------IERLKANDGLKFSQEYESI-----DPGQ 1380

  Fly   975 -----SAREAASQPQCAGLNRPGAPLPYDHSRVVLNHLANAEGLDYVNASTITDHDPRAPAYVAA 1034
                 ::....::|:    ||....:.||||||:|..:....|.||:||:.| |...:..||:|.
  Rat  1381 QFTWENSNSEVNKPK----NRYANVIAYDHSRVLLTSIDGVPGSDYINANYI-DGYRKQNAYIAT 1440

  Fly  1035 QGPLPSTLAHFWQMIWEQGAVVIVALCRLQENGEVACARYWPEEGAEVYHIYEVHLVSEHIWCDD 1099
            |||||.|:..||:|:|||....:|.:.||:|...|.|.:|||..|.|.|.:.:|.|| :.:....
  Rat  1441 QGPLPETMGDFWRMVWEQRTATVVMMTRLEEKSRVKCDQYWPARGTETYGLIQVTLV-DTVELAT 1504

  Fly  1100 YLVRSFYLKNLRTSETRTVTQFHFLSWPHMGVPAQAKALLDFRRKVNKSYRGRRSC------PIV 1158
            |.:|:|.|....:||.|.:.||.|::||..|||.....:|.|.|:|       ::|      |:|
  Rat  1505 YTMRTFALHKSGSSEKRELRQFQFMAWPDHGVPEYPTPILAFLRRV-------KACNPLDAGPMV 1562

  Fly  1159 VHGSAGAGRTGVYILLDLVLERMNKGAREIDIAATLEHLRDQRAGVVATRQQFEFVLMAVAE 1220
            ||.|||.||||.:|::|.:|||| |..:.:||...:..:|.||..:|.|..|:.|:..|:.|
  Rat  1563 VHCSAGVGRTGCFIVIDAMLERM-KHEKTVDIYGHVTCMRSQRNYMVQTEDQYVFIHEALLE 1623

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
IA-2	NP_608562.4	Receptor_IA-2	705..795	CDD:463293	25/110 (23%)
		PTP_DSP_cys	942..1225	CDD:475123	102/293 (35%)
Ptprf	XP_038966082.1	I-set	33..124	CDD:400151
		Ig strand B	50..54	CDD:409353
		Ig strand C	63..67	CDD:409353
		Ig strand E	86..93	CDD:409353
		Ig strand F	104..109	CDD:409353
		Ig strand G	117..120	CDD:409353
		IgI_2_RPTP_IIa_LAR_like	136..232	CDD:409400
		Ig strand A	136..138	CDD:409400
		Ig strand A'	143..147	CDD:409400
		Ig strand B	150..159	CDD:409400
		Ig strand C	164..170	CDD:409400
		Ig strand C'	172..174	CDD:409400
		Ig strand D	183..187	CDD:409400
		Ig strand E	196..201	CDD:409400
		Ig strand F	210..217	CDD:409400
		Ig strand G	220..231	CDD:409400
		IgI_3_RPTP_IIa_LAR_like	241..322	CDD:409401
		Ig strand A	241..243	CDD:409401
		Ig strand A'	247..251	CDD:409401
		Ig strand B	254..262	CDD:409401
		Ig strand C	267..273	CDD:409401
		Ig strand C'	275..277	CDD:409401
		Ig strand D	280..284	CDD:409401
		Ig strand E	289..294	CDD:409401
		FN3	294..718	CDD:442628
		Ig strand F	301..308	CDD:409401
		Ig strand G	312..321	CDD:409401
		FN3	598..1065	CDD:442628	42/232 (18%)
		PTP_DSP_cys	1352..1627	CDD:475123	103/297 (35%)
		R-PTP-F-2	1629..1919	CDD:350477