Protein Alignment IA-2 and Ptprk

DIOPT Version :10

• Sequence 1: NP_608562.4
• Gene: IA-2 / 33277
• FlyBaseID: FBgn0031294
• Length: 1319
• Species: Drosophila melanogaster
• Sequence 2: XP_063121937.1
• Gene: Ptprk / 360302
• RGDID: 619706
• Length: 1485
• Species: Rattus norvegicus
• Alignment Length: 526
• Identity: 145/526 - (27%)
• Similarity: 229/526 - (43%)
• Gaps: 98/526 - (18%)

  Fly   769 TINENRGVKN----NIQRRVGFYVLHAGVGDVIKDLQDPSV----SSSRIELAEQGPDVTHIMAY 825
            |:.:||..|.    .:..|.|:.:....:..|.|:.:...|    .::..|..|..||.......
  Rat   685 TVGDNRTYKGFWNPPLAPRKGYNIYFQAMSSVEKETKTQCVRIATKAAATEEPEVIPDPAKQTDR 749

  Fly   826 MFAGAGAAAVIVIFVTLILI------------KRH--------------------DRKRDKLGGL 858
            :...||.:|.:::|:.|:|:            :||                    .:::|.:|..
  Rat   750 VVKIAGISAGVLVFILLLLVVIVIVKKRYICWRRHICIRNIRRSYYSYSYYLKLAKKRKDAMGNT 814

  Fly   859 QSGIAGAETCSKDYQELCRARMAGKAGGGGNSTGGAAGGGS--------------NEP-APSGRI 908
            :             ||:.....|........||..|....|              |:| .|:..:
  Rat   815 R-------------QEMTHMVNAMDRSYADQSTLHAEDPLSLTFMDQHNFSPRLPNDPLVPTAVL 866

  Fly   909 TSLSKENEGRPPSS--------------RSSTSSWSEEPALTNMDISTGHMVLSYMEDHLRNKGR 959
            ..::.||......|              .|...:....||:...|: ..|:.|....|....|
  Rat   867 VPITDENHSATAESSRLLDVPRYLCEGTESPYQTGQLHPAIRVADL-LQHINLMKTSDSYGFK-- 928

  Fly   960 LQREWEALCRYEAEPSAREAASQPQCAGLNRPGAPLPYDHSRVVLNHLANAEGLDYVNASTI--- 1021
              .|:|:.  :|.:.::.:.|.:.|....||.|..:.||||||:|..:.:....||:||:.|
  Rat   929 --EEYESF--FEGQSASWDVAKKDQNRAKNRYGNIIAYDHSRVILQPVEDDPSSDYINANYIDIW 989

  Fly  1022 --TDHDPRAPAYVAAQGPLPSTLAHFWQMIWEQGAVVIVALCRLQENGEVACARYWPEEGAEVYH 1084
              .|...|...|:|.|||:..|:..||:|:|::.:..||.:..|.|.|.|.|.:|||:: .|||.
  Rat   990 LYRDGYQRPSHYIATQGPVHETVYDFWRMVWQEQSACIVMVTNLVEVGRVKCYKYWPDD-TEVYG 1053

  Fly  1085 IYEVHLVSEHIWCDDYLVRSFYLKNLRTSETRTVTQFHFLSWPHMGVPAQAKALLDFRRKVNKSY 1149
            .::|..| |.....:|:||:|.|:....:|.|.|.||||..||..|||..|..||.|.|:|..|
  Rat  1054 DFKVTCV-EMEPLAEYVVRTFTLERRGYNEIREVKQFHFTGWPDHGVPYHATGLLSFIRRVKLS- 1116

  Fly  1150 RGRRSCPIVVHGSAGAGRTGVYILLDLVLERMNKGAREIDIAATLEHLRDQRAGVVATRQQFEFV 1214
            ....:.|||||.||||||||.||::|::|: |.:....:||...::.||.:|..:|.|.:|:.|:
  Rat  1117 NPPSAGPIVVHCSAGAGRTGCYIVIDIMLD-MAEREGVVDIYNCVKALRSRRINMVQTEEQYIFI 1180

  Fly  1215 LMAVAE 1220
            ..|:.|
  Rat  1181 HDAILE 1186

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
IA-2	NP_608562.4	Receptor_IA-2	705..795	CDD:463293	6/29 (21%)
		PTP_DSP_cys	942..1225	CDD:475123	105/284 (37%)
Ptprk	XP_063121937.1	None