Protein Alignment IA-2 and clr-1

DIOPT Version :10

• Sequence 1: NP_608562.4
• Gene: IA-2 / 33277
• FlyBaseID: FBgn0031294
• Length: 1319
• Species: Drosophila melanogaster
• Sequence 2: NP_001022209.1
• Gene: clr-1 / 3565419
• WormBaseID: WBGene00000548
• Length: 1444
• Species: Caenorhabditis elegans
• Alignment Length: 1303
• Identity: 268/1303 - (20%)
• Similarity: 435/1303 - (33%)
• Gaps: 443/1303 - (33%)

  Fly   265 LCANLAP--TPPEFG----DPASALAY-----VRFTPPEPEAELDYYEQPAGPAQF---YPALRK 315
            :|....|  ||.:.|    .|::.|..     .::...||..   |..:...|.||   :....:
 Worm    87 MCPRSCPAITPKQCGYNYRTPSTCLLMDADYRSKYDVKEPTC---YSRKCVCPPQFDDVHVTANQ 148

  Fly   316 KQVRESDADDMYLNRMLQ----DRRRL----RHDPSELEHFG---------KMDGHGQSTQLDAP 363
            |.:|        ||..|.    |:|.|    |..||.....|         .:|..|   .:|..
 Worm   149 KPLR--------LNSTLLPTKCDKRDLAVVARAHPSTSVSKGIDVTLFCCINVDPEG---FIDVA 202

  Fly   364 SIMDAFLDTERQRIEREQQLAAAEQDADRRAEQNRL-ELY-----QILAASEPDPQPYQRKPAAQ 422
            |:.  |:  :...|.||   |.:...|.|.....|: |.|     :|..|...|...|..:..|.
 Worm   203 SVF--FI--QNGTIMRE---ATSHPFAPRNGLARRVHEKYSCWELEIKNAQTSDSGSYMCRVTAS 260

  Fly   423 PNAMDQLEAIVEQQQQRELKEQQEQAKAPVYVPPEEV---NESSELYFPDN-------------F 471
            .:.:|     |....|.|:||...:..:..|..|::|   :.||.|...|:             .
 Worm   261 ASDLD-----VTDTMQFEVKEHARRTHSYWYKRPKKVMPPSSSSSLKTSDDDDDSTPRQIKNLTV 320

  Fly   472 APFKR---ARGRSRGGLAEEVEDEQPKRSFFRELAGEQGLVQEPPLRFRHVETEVDATPELVKRR 533
            .|.:|   ....|.||               .::|.:..||:....|.:.|.::.:.|      .
 Worm   321 NPSERDAIVTWESEGG---------------EDMAIDLRLVRRTDTRGQVVFSKDNLT------S 364

  Fly   534 PASFKQL---DPYDVSLQQQEMAFESGLLRNSLTPLEEEAMLASNS---FPRQAKSQRVYTEGGL 592
            |.|.|.|   .||.:        |.||  .|...|.|......:..   ||.:.:..||...|..
 Worm   365 PVSIKDLRAATPYTL--------FVSG--NNGQVPFEFTEHFTTKQKRPFPPKEEDVRVLNSGSA 419

  Fly   593 L---------------------------------LMPQD-----EQDTDGMQADEPENVKQSLLA 619
            |                                 |.|.|     |.|......|..||..:....
 Worm   420 LSCEVEWKSPAEPNGRITKYFVSVRGAMRKSDGSLTPDDLPAAVEVDKRCANWDGDENTSKHNGI 484

  Fly   620 NMLGFARHERLDVKKPGPLLGPPSLGSAELSNQLETEKAHKQKGHGNKEVLPAHIKGN------D 678
            |.:.|| :|....|. |||  .|:      .|...|..|....|..    |||....|      .
 Worm   485 NPIDFA-NEFYSCKF-GPL--KPN------RNYTVTVWAENSAGRS----LPAVFHKNCVTNYAQ 535

  Fly   679 EDDAHKKKKVMKQQHSA--------EDHAPHTVDTEYVHVFVKNPIDSWNDGQRIMKELEQI-LH 734
            .|.....:.::...||.        .|.....:...|:.:.   |:.: |....|:.:.|:| :|
 Worm   536 PDMVETPQPLLSNNHSTFSLTFPQPPDDINGPISCYYIAIV---PLPA-NVSLDILPKSEEIVMH 596

  Fly   735 M----------------QGYFSYLTVQQHEVSFRVNSNNPERKTAGD--------------VART 769
            .                :.:|:|:.....::        ||..|.||              ::|.
 Worm   597 SFSKVFTNNLLPSSAEEKRFFAYIAESYVQL--------PEETTIGDGVRVSDLKACNVQYLSRY 653

  Fly   770 INENRGVKNNIQRRVGFYVL--------------HAGVGDVIKDLQDPSVS-SSRIELAE----- 814
            .:|:..::..: :..||.::              :....::.::|.|.||| :||...|.
 Worm   654 SSEDLALRRGL-KYTGFLIVRVDKEEELNRKDVRNGADPNIFRNLIDKSVSPTSRTRTASPMSRH 717

  Fly   815 ------QGPDVTH------------------------IMAYMFAGAGAAAVIVIFVTLILIKRHD 849
                  .||...:                        |:.::...|.|..|.:.||        :
 Worm   718 LRQLHLSGPAYGYSAYFKPILLDTESSSSGFGIFMKIILPFLLFLAFATGVTMFFV--------N 774

  Fly   850 RKRDKLGGLQSGIAGAETC-------SKDYQELCRARMAGKAGGGGNSTGGAAGGGSNEPAPSGR 907
            ||...|         :..|       |||..|
 Worm   775 RKGHML---------STWCPLFTKMTSKDVVE--------------------------------- 797

  Fly   908 ITSLSKENEGRPPSSRSSTSSWSEEPALTNMDISTGHMVLSYMEDHLRNKGRLQREWEALCRYEA 972
             .:|.|:..|..|..                |:.|.::|.....|.|     ..:|:|:|..::.
 Worm   798 -RTLLKQTFGAIPVD----------------DLPTEYVVRHRDTDFL-----FAQEYESLPHFQL 840

  Fly   973 EPSAREAASQPQCAGLNRPGAPLPYDHSRVVLNHLANAEGLDYVNASTITDHDPRAPAYVAAQGP 1037
            :   ..|:::.:.|..||......:|.:||.|..:...:..||:||:.|.....: ..::|||.|
 Worm   841 D---TVASNRKENAIKNRYNDIRAFDDTRVKLKKINGDDYSDYINANFIKSWKEK-KLFIAAQAP 901

  Fly  1038 LPSTLAHFWQMIWEQGAVVIVALCRLQENGEVACARYWPEEGAEVYH--IYEVHLVSEHIWCDDY 1100
            :.:|:..||:|:|||.:.:||.:..|.|.....||:|||:|....|.  |.|....|.|   .||
 Worm   902 VDATIGDFWRMVWEQESYLIVMVANLTEKNRQQCAKYWPDEQITRYGDIIVEPASFSFH---SDY 963

  Fly  1101 LVRSF-------------------------YLKNLRTSETRTVTQFHFLSWPHMGVPAQAKALLD 1140
            .:|:|                         .:|....:.:|.:.|:||.:|.....|..:..||.
 Worm   964 AIRAFDIAHIGECGPDVIPNGNGVEYANVPIVKGQFANNSRRILQYHFTNWNDYKAPECSTGLLR 1028

  Fly  1141 FRRKVNKSYRGRRSCPIVVHGSAGAGRTGVYILLDLVLERMNKGAREIDIAATLEHLRDQRAGVV 1205
            |..::.:..:...| |:|:|.|||.||||.:|.:|.:|::. ....:.:|...:.:||.||..:|
 Worm  1029 FMYRLRELPQFNNS-PVVIHCSAGVGRTGTFISIDSMLDQC-LAEDKANIFEFVCNLRRQRNLMV 1091

  Fly  1206 ATRQQFEFVLMAVAEEVHAILKALPANTSGEKRELD----------KDPVVGGGSSSTT------ 1254
            .:.:|:.|:..|:| |.|     :..:|..:.|:.:          :|..|.....|:|
 Worm  1092 QSLEQYVFIYKALA-EWH-----MYGDTDEDVRDFEDHYQRLCASNRDRAVSFNQQSSTNGSISP 1150

  Fly  1255 ------TKEPLKEDKAQEAAEEE---------APTSSSKAAAAAKKEKEKDKDKEEKQAKDQAKV 1304
                  ::|.:.....:...|||         .|.||:.||            |:|...|::.:.
 Worm  1151 RVAIVSSRESMTTSNGETGLEEEFKKLERNLTTPLSSNFAA------------KDENLLKNRYEA 1203

  Fly  1305 AEP 1307
            |.|
 Worm  1204 AVP 1206

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
IA-2	NP_608562.4	Receptor_IA-2	705..795	CDD:463293	18/134 (13%)
		PTP_DSP_cys	942..1225	CDD:475123	86/309 (28%)
clr-1	NP_001022209.1	FN3	403..523	CDD:238020	28/133 (21%)
		PTPc	827..1106	CDD:214550	81/293 (28%)
		PTPc	1169..1437	CDD:214550	13/50 (26%)