DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment IA-2 and Ptp36E

DIOPT Version :9

Sequence 1:	NP_608562.4	Gene:	IA-2 / 33277	FlyBaseID:	FBgn0031294	Length:	1319	Species:	Drosophila melanogaster
Sequence 2:	NP_001286033.1	Gene:	Ptp36E / 35091	FlyBaseID:	FBgn0267486	Length:	682	Species:	Drosophila melanogaster

Alignment Length:	422	Identity:	115/422 - (27%)
Similarity:	180/422 - (42%)	Gaps:	96/422 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly   884 AGGGGNSTGGAAGG--GSNEPAPSGRITSLSKE-------------------NEGRPPSSRSSTS 927
            |.|||:|  ||.||  |.:....|.|...:.|:                   |.|.....|....
  Fly     4 ATGGGSS--GAGGGKTGKHRSRSSARYDDVEKQQRKSRAIVSIPNTIKLSMLNSGLLSFERIKLE 66

  Fly   928 SWSEEPALTNMDISTGHMVLSYMEDHLRNKGRLQREWEAL---------------CRYEAEPSAR 977
            :..|..:|:. .|..|.:.:.    |......|:|::..|               ||:..:.:..
  Fly    67 ARDENNSLSK-TIPNGPIDIR----HFLKLCDLRRKFPVLYKLEFQTAAKVESNTCRHALKKNNL 126

  Fly   978 EAASQPQCAGLNRPGAPLPYDHSRVVLNHLANAEGLDYVNASTITDHDPRAPAYVAAQGPLPSTL 1042
            |....|:|         :|||::||||..:...:..||||||.: |...:..||:..|||:..|:
  Fly   127 EKNQNPKC---------IPYDYNRVVLEKVGGLQDSDYVNASYV-DSLLKPNAYIVTQGPVEETV 181

  Fly  1043 AHFWQMIWEQGAVVIVALCRLQENGEVACARYWPEEGAEVYHIYE---VHLVSEHIWCDDYLVRS 1104
            ..:|:|:|::....||.|.:..:..:|.|.:||| ...||:..|.   :::|.|. ...::.:|:
  Fly   182 QAYWRMVWQENISAIVMLTKTFDFAKVMCHQYWP-PNMEVHEQYGDIFINIVREE-QLANFHIRT 244

  Fly  1105 FYLKNL----RTSETRTVTQFHFLSWPHMGVPAQAKALLDFRRKV----------NKSYRGRRSC 1155
            |.|..:    ..::.|.:.|||:..|.....|. :.|||:|||:|          ....||
  Fly   245 FRLYKMNEKQEVTDERLILQFHYTEWYSHSCPF-SNALLEFRRRVRLVVGNIIKDEDDMRG---- 304

  Fly  1156 PIVVHGSAGAGRTGVYILLDLVLERMNKGARE---IDIAATLEHLRDQRAGVVATRQQFEFVLMA 1217
            ||:||.|.|.||:|||:.:|..||.    |.|   .::...|:.||..|.|:|...:|::|:...
  Fly   305 PILVHCSDGGGRSGVYMSIDANLEL----AEEEECFNVFGYLKKLRQSRKGLVENVEQYKFIYDT 365

  Fly  1218 VAE------------EVHAILKALPANTSGEK 1237
            :.|            |:...|||.....||.|
  Fly   366 LEEHIICGKTWFPVSELSDRLKAKARRNSGTK 397

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
IA-2	NP_608562.4	Receptor_IA-2	708..795	CDD:288410
		PTPc	960..1220	CDD:214550	86/294 (29%)
		PTPc	995..1220	CDD:238006	78/244 (32%)
Ptp36E	NP_001286033.1	Y_phosphatase	125..368	CDD:395053	81/263 (31%)
Ptp36E	NP_001286033.1	Y_phosphatase	428..671	CDD:395053
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45443533
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.840