DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment IA-2 and ptprna

DIOPT Version :9

Sequence 1:	NP_608562.4	Gene:	IA-2 / 33277	FlyBaseID:	FBgn0031294	Length:	1319	Species:	Drosophila melanogaster
Sequence 2:	NP_001124060.2	Gene:	ptprna / 324790	ZFINID:	ZDB-GENE-030131-3511	Length:	903	Species:	Danio rerio

Alignment Length:	1086	Identity:	376/1086 - (34%)
Similarity:	524/1086 - (48%)	Gaps:	235/1086 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly   174 GNVGCQFVRTLCIPHSEVCYDDNIFGKCIPTTGVDVEDIEKTPLTEDQSRVLATMLEELQGAGLG 238
            |..||.|.:.|| ...:.|.||.|||:|..:....|:.....|:.:.    |..:|:||...|..
Zfish    23 GKYGCLFEKRLC-SREQFCSDDKIFGQCRSSRHDQVQYQVSVPVLQR----LQQVLKELMLQGFS 82

  Fly   239 WDHPYVQCRIQGSLFSL-----QRQQQLPPNLCANLAPTPPEFGDPASALAYVRFTPPEPEAELD 298
            |.....|..|...|..:     |:.|...|         ||    ||:...|     ..|.:|
Zfish    83 WQDEITQQIIAKELSRIPHTRTQKSQNAQP---------PP----PAAKKVY-----SSPNSE-- 127

  Fly   299 YYEQPAGPAQFYPALRKKQVRESDADDMYLNRMLQDRRRLRHDPSELEHFGKMDGHGQSTQLDAP 363
                 .||||.|            .|.|.|:.......|::..|  ::.:..:. .|.:..|...
Zfish   128 -----PGPAQSY------------VDYMVLDPHQSSPLRMQTVP--VDPYSYLQ-EGMTHSLHPH 172

  Fly   364 SIMDAFLDTERQRIEREQQLAAAEQ-DADRRAEQNRLELYQILAASEPDPQPYQRKPAAQPNA-- 425
            :.|.         .:|....:.::| :.||:..|:.:.||  |::::|..:  .|..||.|.|
Zfish   173 ASMG---------YQRPSSRSGSQQRERDRQLLQDAVSLY--LSSAQPSFR--HRGAAALPAAPY 224

  Fly   426 MDQLEAIVEQQQQRELKEQQEQAKAPVYVPPEEVNESSELYFPDNFAPFKRARGRSRGGLAEEVE 490
            .:.|:..:|..:...|.||:...|     ||::.:                    |..||.::.
Zfish   225 YEDLDFPLEYGEDYTLHEQRTNKK-----PPQDYS--------------------SVAGLDDDT- 263

  Fly   491 DEQPKRSFFRELAG-EQGLVQEPPLRFRHVETEVDATPELVKRRPASFKQLDPYDVSLQQQEMAF 554
                    ..:|.. .:|...:|.          |.:|:.:||..... ||      ||..|...
Zfish   264 --------LTQLGSLLKGFGVDPR----------DLSPQQIKRLTLVL-QL------LQNMEKTD 303

  Fly   555 ES-GLLRNSLTPLEEEAMLASNSFPRQAKSQRVYTEGGLLLMPQDEQDTDGMQADEPENVKQSLL 618
            :| |      |...:|.::|.        |.:|...||                     ...|.:
Zfish   304 QSPG------TVTVKETIVAG--------SDKVTENGG---------------------KSPSTI 333

  Fly   619 ANMLGFARHERL-----DVKKPGPLLGP--PSLGSAELSNQLETEKAHKQKGHGNKEVLPAHIKG 676
            :.:.....|::.     ....|.|:..|  |:|.:.:|..:.:|                |:|..
Zfish   334 SALPSAPTHQQAPTQPPSTSTPAPVTVPAEPTLSAKDLDLKEKT----------------ANILK 382

  Fly   677 NDEDDAHKKKKVMKQQHSAEDHAPHTVDTEYVHVFVKNPIDSWNDGQRIMKELEQILHMQ-GYFS 740
            ..:|..:.::                   ||.::.......|..||.::::.|.:.:|:. ..|.
Zfish   383 TTKDGTNTRE-------------------EYGYIVTNQSHLSLYDGVKLLETLAERIHLSTSSFI 428

  Fly   741 YLTVQQHEVSFRVNSNNPERKTAGDVARTINENRGV--KNNIQRRVGFYVLHAGVGDVIKDLQDP 803
            .::|....::||:. .|....:|.|||     |:.|  ||.::...|..::..|||:..:....|
Zfish   429 NISVVGSALTFRIR-QNALNLSAEDVA-----NKAVAEKNFLEGETGLKIIQTGVGERSEGRGLP 487

  Fly   804 SVSSSRIELAEQGPDVTHIMAYMFAGAGAAAVIVIFVTLILIKRHDRK--RDKLG-GLQSGIAGA 865
              .::||....:|     ::..|.|.|....|:::.:.:..::.|.|:  ..||| |.:   |||
Zfish   488 --QATRIGEGSRG-----VVLTMVAMACVGTVLLVALAVACLRHHARQLASGKLGLGPE---AGA 542

  Fly   866 ETCSKDYQELCRARMAGKAGGGGNSTGGAAGGGSNEPAPSGRITSLSKENEGRP---PSSRSSTS 927
            || ..|||||||..||.|:.......||..|      ..:.|::|:|.:....|   |||.|||.
Zfish   543 ET-HFDYQELCRQHMAAKSSFTRPEPGGRRG------TDTSRVSSVSSQFSDGPQHSPSSHSSTP 600

  Fly   928 SWSEEPALTNMDISTGHMVLSYMEDHLRNKGRLQREWEALCRYEAEPSAREAASQPQCAG---LN 989
            |||||||.:|||||||||:|:||||||:||.|||:||||||.|:||||   :.|..||..   .|
Zfish   601 SWSEEPAQSNMDISTGHMILAYMEDHLKNKDRLQKEWEALCSYQAEPS---SVSVAQCESNMEKN 662

  Fly   990 RPGAPLPYDHSRVVLNHLANAEGLDYVNASTITDHDPRAPAYVAAQGPLPSTLAHFWQMIWEQGA 1054
            |....:|||||||.|....|....||:|||||.|||||.|||:|.|||||.|:|.||||:||.|.
Zfish   663 RYPDFVPYDHSRVKLKAEVNPSKGDYINASTIIDHDPRLPAYIATQGPLPHTVADFWQMVWENGC 727

  Fly  1055 VVIVALCRLQENGEVACARYWPEEGAEVYHIYEVHLVSEHIWCDDYLVRSFYLKNLRTSETRTVT 1119
            .|||.:..|.|:||..|.||||:||:.:|:||||:||||||||.|:|||||||||::|.||||:|
Zfish   728 TVIVMMTALVEDGEKQCERYWPDEGSSLYNIYEVNLVSEHIWCKDFLVRSFYLKNVQTQETRTLT 792

  Fly  1120 QFHFLSWPHMGVPAQAKALLDFRRKVNKSYRGRRSCPIVVHGSAGAGRTGVYILLDLVLERMNKG 1184
            |||.||||..|:|:..:.||||||||||.||| |||||:||.|.|.||||.|||:|:||.||.||
Zfish   793 QFHLLSWPANGIPSSTRPLLDFRRKVNKCYRG-RSCPIIVHCSNGTGRTGTYILIDMVLNRMAKG 856

  Fly  1185 AREIDIAATLEHLRDQRAGVVATRQQFEFVLMAVAEEVHAILKALP 1230
            .:||||||||||:||||..:|.|:.||||.|.||||||:|||||||
Zfish   857 VKEIDIAATLEHIRDQRPSMVRTKDQFEFALTAVAEEVNAILKALP 902

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
IA-2	NP_608562.4	Receptor_IA-2	708..795	CDD:288410	21/89 (24%)
		PTPc	960..1220	CDD:214550	168/262 (64%)
		PTPc	995..1220	CDD:238006	150/224 (67%)
ptprna	NP_001124060.2	RESP18	47..>105	CDD:291609	13/61 (21%)
		DUF2360	284..>370	CDD:287161	23/127 (18%)
		Receptor_IA-2	395..480	CDD:288410	22/90 (24%)
		PTPc	633..892	CDD:214550	168/262 (64%)
		PTPc	660..892	CDD:238006	152/232 (66%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	334	1.000	Domainoid score	I1101
eggNOG	1	0.900	-	-		E2759_KOG0793
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	518	1.000	Inparanoid score	I1238
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D281324at33208
OrthoFinder	1	1.000	-	-		FOG0002390
OrthoInspector	1	1.000	-	-		otm24269
orthoMCL	1	0.900	-	-		OOG6_105521
Panther	1	1.100	-	-	LDO	PTHR46106
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5067
SonicParanoid	1	1.000	-	-		X1583
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	13	12.860