DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment IA-2 and Ptp10D

DIOPT Version :9

Sequence 1:	NP_608562.4	Gene:	IA-2 / 33277	FlyBaseID:	FBgn0031294	Length:	1319	Species:	Drosophila melanogaster
Sequence 2:	NP_996413.2	Gene:	Ptp10D / 32115	FlyBaseID:	FBgn0004370	Length:	1990	Species:	Drosophila melanogaster

Alignment Length:	1202	Identity:	266/1202 - (22%)
Similarity:	430/1202 - (35%)	Gaps:	360/1202 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly   202 IPTTGVDVEDIEKTPLTEDQSRVLATMLEELQGAGLGWDHPYVQCRIQGSLFSLQRQQQLPPNLC 266
            :.:|..|:.|     :|:.:...:     ::.....|.:.|..|          :....:|||..
  Fly   632 VRSTEADITD-----MTKGEKYTI-----QVNTVSFGVESPVPQ----------EVNTTVPPNPV 676

  Fly   267 ANLAPTPPEFGDPASALAYVRFTPPEPEAELDYYEQPAGPAQFYPALRKKQVRES-DADDMYLNR 330
            :|:.    :..|..:    :....|:||..::.|.....|:.....::.|.|.|: .|||:...|
  Fly   677 SNII----QLVDSRN----ITLEWPKPEGRVESYILKWWPSDNPGRVQTKNVSENKSADDLSTVR 733

  Fly   331 M----LQDRRRLRHDPSELEHFGKMDG----HGQSTQLDAPSIMDAFLDTERQR----------- 376
            :    |....:.:.| .:...:|.:.|    :.::..|....::.|..:.|.:|
  Fly   734 VLIGELMPGVQYKFD-IQTTSYGILSGITSLYPRTMPLIQSDVVVANGEKEDERDTITLSYTPTP 797

  Fly   377 -----------------IEREQQLAAAEQDADRRAEQNRL---ELYQIL-------AASEPDPQP 414
                             |..:::||   .|.||:.....|   .||.|.       .||    .|
  Fly   798 QSSSKFDIYRFSLGDAEIRDKEKLA---NDTDRKVTFTGLVPGRLYNITVWTVSGGVAS----LP 855

  Fly   415 YQRKPAAQPNAMDQLEAIVEQQQQRELKEQQEQAKAPVYVPPEEVNESSELYF-PDNFAPFKRAR 478
            .||:....|..:.||.|......:..|:..         :|..|.|:....|. .||.
  Fly   856 IQRQDRLYPEPITQLHATNITDTEISLRWD---------LPKGEYNDFDIAYLTADNL------- 904

  Fly   479 GRSRGGLAEE--------VEDEQPKRSFFRELAGEQG-----LVQEPPLRFRHVETEVDATPELV 530
                  ||:.        :.|.:|.|::...:....|     |....||.......|  |.|..|
  Fly   905 ------LAQNMTTRNEITISDLRPHRNYTFTVVVRSGTESSVLRSSSPLSASFTTNE--AVPGRV 961

  Fly   531 KRRPASFKQLDPYDVSLQQQEMAFESGLLRNSLTPLEEEAMLASNSFPRQAKSQRVYTEGGLLLM 595
            :|       ..|.||  |..|:.||..|      |..|     :|...||...  .||....|
  Fly   962 ER-------FHPTDV--QPSEINFEWSL------PSSE-----ANGVIRQFSI--AYTNINNL-- 1002

  Fly   596 PQDEQDTD-GMQADEPE-------NVK---------QSLLANMLGFARHERLDVKKPGPLLGPPS 643
                  || |||..|.|       |:|         |:..|  :||. .|| :.::..|:|.||.
  Fly  1003 ------TDAGMQDFESEEAFGVIKNLKPGETYVFKIQAKTA--IGFG-PER-EYRQTMPILAPPR 1057

  Fly   644 LGSAELSNQLETEKAHKQKGHGNKEVLPAHI-KGNDEDDAHKKKKVMKQQHS---------AEDH 698
            ..:                     :|:|..: :.:.......:|.....|:.         |||.
  Fly  1058 PAT---------------------QVVPTEVYRSSSTIQIRFRKNYFSDQNGQVRMYTIIVAEDD 1101

  Fly   699 APHTVDTEYVHVFVKNPIDSWNDGQRIMKELEQILHMQGYFSYLTVQQHEVSFRVNSNNPERKTA 763
            |.:....|         :.||             |.:|.|..:|..|..:..:...:.:.|..|.
  Fly  1102 AKNASGLE---------MPSW-------------LDVQSYSVWLPYQAIDPYYPFENRSVEDFTI 1144

  Fly   764 GDVARTINENRGVKNNIQRRVGFYVLHAGVGDVIKDLQDPSVSSSRIEL-AEQGPDVTHIMAYMF 827
                       |.:|....::|:      ....:|     |.::.|::: |..|.|.....||.|
  Fly  1145 -----------GTENCDNHKIGY------CNGPLK-----SGTTYRVKVRAFTGADKFTDTAYSF 1187

  Fly   828 --------------AGAGAAAVIVIFVTLILIKRHDRKRDKLGGLQSGIAGAETCSKDYQELCRA 878
                          .......::|:.|||:..||.                ...|.|..::
  Fly  1188 PIQTDQDNTSLIVAITVPLTIILVLLVTLLFYKRR----------------RNNCRKTTKD---- 1232

  Fly   879 RMAGKAGGGGNSTGGAAGGGSNEPAPSGRITSLSKENEGRPPSSRSSTSSWSEEPALTNMDISTG 943
                            :....|...|...|      .:.||    ....:::|...|.:.|   .
  Fly  1233 ----------------SRANDNMSLPDSVI------EQNRP----ILIKNFAEHYRLMSAD---S 1268

  Fly   944 HMVLSYMEDHLRNKGRLQREWEALCRYEAEPSAREAASQPQCAGLNRPGAPLPYDHSRVVLNHLA 1008
            ....|...:.|::.||.|.     |.:...|     .::|:    ||....|||||||..|..:.
  Fly  1269 DFRFSEEFEELKHVGRDQP-----CTFADLP-----CNRPK----NRFTNILPYDHSRFKLQPVD 1319

  Fly  1009 NAEGLDYVNASTITDHD-PRAPAYVAAQGPLPSTLAHFWQMIWEQGAVVIVALCRLQENGEVACA 1072
            :.||.||:||:.:..|: ||  .::..||||.||...||:|.||..:..||.|.|..|.|...|.
  Fly  1320 DDEGSDYINANYVPGHNSPR--EFIVTQGPLHSTRDDFWRMCWESNSRAIVMLTRCFEKGREKCD 1382

  Fly  1073 RYWPEEGAEV-YHIYEVHLVSEHIWCDDYLVRSFYLKNLRTSETRTVTQFHFLSWPHMGVPAQAK 1136
            :|||.:...| |...:|.::::..:. |:::..|.|  .|.||.|.:..|||.:||..|||...:
  Fly  1383 QYWPNDTVPVFYGDIKVQILNDSHYA-DWVMTEFML--CRGSEQRILRHFHFTTWPDFGVPNPPQ 1444

  Fly  1137 ALLDFRRKVNKSYR---GRRSCPIVVHGSAGAGRTGVYILLDLVLERMNKGAREIDIAATLEHLR 1198
            .|:.|.|    ::|   |....|||||.|||.||:|.:|.||.:|:::|. :..:||...:..:|
  Fly  1445 TLVRFVR----AFRDRIGAEQRPIVVHCSAGVGRSGTFITLDRILQQINT-SDYVDIFGIVYAMR 1504

  Fly  1199 DQRAGVVATRQQFEFV---LMAVAEEVHAILKALPANT-------SGEKRELDKDPVVGGGSSST 1253
            .:|..:|.|.||:..:   |:||.|....|:.  ||..       .|::.:||::..|.......
  Fly  1505 KERVWMVQTEQQYICIHQCLLAVLEGKENIVG--PAREMHDNEGYEGQQVQLDENGDVVATIEGH 1567

  Fly  1254 TTKEPLKEDKAQEAAEEEA--------PTSSS 1277
            .:...|::.:|:...:|.|        |.:||
  Fly  1568 LSHHDLQQAEAEAIDDENAAILHDDQQPLTSS 1599

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
IA-2	NP_608562.4	Receptor_IA-2	708..795	CDD:288410	12/86 (14%)
		PTPc	960..1220	CDD:214550	94/267 (35%)
		PTPc	995..1220	CDD:238006	88/232 (38%)
Ptp10D	NP_996413.2	fn3	124..205	CDD:278470
		fn3	220..304	CDD:278470
		fn3	315..391	CDD:278470
		FN3	405..494	CDD:238020
		FN3	511..574	CDD:238020
		FN3	583..671	CDD:238020	7/58 (12%)
		fn3	683..753	CDD:278470	15/74 (20%)
		fn3	787..850	CDD:278470	10/65 (15%)
		fn3	866..935	CDD:278470	15/90 (17%)
		fn3	961..1043	CDD:278470	31/114 (27%)
		PTPc	1272..1525	CDD:214550	95/276 (34%)
		PTPc	1298..1525	CDD:238006	88/240 (37%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45443505
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm46470
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	2.840