DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment IA-2 and Ptpmeg2

DIOPT Version :9

Sequence 1:	NP_608562.4	Gene:	IA-2 / 33277	FlyBaseID:	FBgn0031294	Length:	1319	Species:	Drosophila melanogaster
Sequence 2:	NP_572576.1	Gene:	Ptpmeg2 / 31907	FlyBaseID:	FBgn0028341	Length:	827	Species:	Drosophila melanogaster

Alignment Length:	381	Identity:	132/381 - (34%)
Similarity:	195/381 - (51%)	Gaps:	46/381 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly   884 AGGGGNSTGGAAGGGSNEPAPSGRITSLSKENEGRPPSSRSSTSSWSEEPALTNMDISTGHMVLS 948
            ||..|.:.|....||       |...|   ||   ||||.|  |.:|::.:|...:  .....:.
  Fly   472 AGAAGAAAGTTTNGG-------GEFWS---EN---PPSSAS--SGFSDDDSLAGQE--GDPKPID 519

  Fly   949 YMEDHLRNKGR--LQREWEALCRYEAEPS---AREAASQPQCAGLNRPGAPLPYDHSRVVLNHLA 1008
            .:...::.:||  |.:|:..:.....|.:   ||..|:..:    ||....|.||||||||.|..
  Fly   520 QIVQMVKQRGRHGLIKEYADIRNRAPEGTFLHARMRANLTK----NRYTDVLCYDHSRVVLAHED 580

  Fly  1009 NAEGLDYVNASTITDHDPRAPAYVAAQGPLPSTLAHFWQMIWEQGAVVIVALCRLQENGEVACAR 1073
            ..|..||:||:.: |...:..||::.|||||.|...||:|||||..:|||...|:.|.|.|.|.:
  Fly   581 GDEPSDYINANFV-DGYKQKNAYISTQGPLPKTSQDFWRMIWEQHCLVIVMTTRVMERGRVKCGQ 644

  Fly  1074 YW--PEEGAEVYHIYEVHLVSEHIWC-DDYLVRSFYLKNLRTSETRTVTQFHFLSWPHMGVPAQA 1135
            ||  .||.:..:..|.|..:|  :.| :||:|.|..|:|::|.|.|.|:.:.|.|||..|||:.|
  Fly   645 YWEPTEESSLEFGDYHVRTIS--VECNEDYMVASLELRNIKTDEIRNVSHWQFTSWPDYGVPSSA 707

  Fly  1136 KALLDFRRKVNK-----------SYRGR-RSCPIVVHGSAGAGRTGVYILLDLVLERMNKGAREI 1188
            .|:|:|.:||.:           ::.|. |..|||||.|||.||||.:|.||:.:.|: :.....
  Fly   708 MAMLNFLQKVREKQAQLVQGLGDTWAGHPRGPPIVVHCSAGIGRTGTFITLDICISRL-EDVGTA 771

  Fly  1189 DIAATLEHLRDQRAGVVATRQQFEFVLMAVAEEVHAILKALPANTSG-EKRELDKD 1243
            ||..|:|.:|.|||..:....|:.|..:|:.|..::.......:.:| ::||.|.:
  Fly   772 DIRGTVEKIRSQRAYSIQMPDQYVFCHLALIEYAYSRGMLQTVDLAGFDEREPDSE 827

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
IA-2	NP_608562.4	Receptor_IA-2	708..795	CDD:288410
		PTPc	960..1220	CDD:214550	107/277 (39%)
		PTPc	995..1220	CDD:238006	99/239 (41%)
Ptpmeg2	NP_572576.1	CRAL_TRIO_N	<114..144	CDD:215024
		SEC14	170..314	CDD:238099
		Y_phosphatase	557..803	CDD:278528	101/253 (40%)
		PTPc	559..803	CDD:238006	101/251 (40%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45443529
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm46470
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	2.840