DRSC/TRiP Functional Genomics Resources

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Protein Alignment IA-2 and Ptp4E

DIOPT Version :9

Sequence 1:NP_608562.4 Gene:IA-2 / 33277 FlyBaseID:FBgn0031294 Length:1319 Species:Drosophila melanogaster
Sequence 2:NP_001162669.1 Gene:Ptp4E / 31425 FlyBaseID:FBgn0004368 Length:1767 Species:Drosophila melanogaster


Alignment Length:1443 Identity:299/1443 - (20%)
Similarity:507/1443 - (35%) Gaps:427/1443 - (29%)


- Green bases have known domain annotations that are detailed below.


  Fly    37 ARGTAGHQESATGECQQFWSKQRPPFDQQQQQEDQDPEQDPQQHPSTPQE--SVHHHRSPRQHEL 99
            ::|.|.:....|.     :::...|..|:.:..||......:...::.|:  .||:.|:..:.|.
  Fly   517 SKGVASNASDITR-----YTRPAAPLIQELRSIDQGLMLSWRSDVNSRQDRYEVHYQRNGTREER 576

  Fly   100 LHHQRKVPPTL----PARGR----HLISEGARRREVRGCGAGGGGLLCCSLDALSRPAKLLQFGV 156
            .....:...|:    |..|.    |.||.|.|                      |.|....|   
  Fly   577 TMATNETSLTIHYLHPGSGYEVKVHAISHGVR----------------------SEPHSYFQ--- 616

  Fly   157 LLLILLLATHGDLAQAEGNVGCQFVRT-LCIPHSEVCYDDNIFGKCIPTTGVDVEDIEK-TPLTE 219
                      ....:...|:..|.|.| |.:.|.: ..:.:.|.:.:.....|....:: :.|.|
  Fly   617 ----------AVFPKPPQNLTLQTVHTNLVVLHWQ-APEGSDFSEYVVRYRTDASPWQRISGLHE 670

  Fly   220 DQSRVL-----ATMLEELQGAGLGWDHPYVQCRIQGSLFSLQRQQQLPPNLCANLAPTPPEFGDP 279
            :::|:.     ...|.::.....|.:.|:          .|:....:||...:|:.|....    
  Fly   671 NEARIKDMHYGERYLVQVNTVSFGVESPH----------PLELNVTMPPQPVSNVVPLVDS---- 721

  Fly   280 ASALAYVRFTPPEPEAELDYYEQPAGPAQFYPALRKKQVRESD----------ADDM-----YLN 329
                ..:....|.|:..:|:|.....|......:..|.|.:.:          .:|:     |..
  Fly   722 ----RNLTLEWPRPDGHVDFYTLKWWPTDEEDRVEFKNVTQLEDLSSPSVRIPIEDLSPGRQYRF 782

  Fly   330 RMLQDRRRLRHDPSEL----------EHFGKMDGHGQ----------------STQLDA------ 362
            .:......:|...:.|          :.|....||.|                ||:.|.      
  Fly   783 EVQASSNGIRSGTTHLSTRTMPLIQSDVFIANAGHEQGQDETITLSYTPTPADSTRFDIYRFSMG 847

  Fly   363 -PSIMDAFLDTERQRIEREQQLAAAEQDADRRAEQNRL---ELYQIL-------AASEPDPQPYQ 416
             |:|.|            :::||   .|.:|:...:.|   :||.:.       .||    .|.|
  Fly   848 DPTIKD------------KEKLA---NDTERKLSFSGLTPGKLYNVTVWTVSGGVAS----LPVQ 893

  Fly   417 RKPAAQPNAMDQLEAI--------------VEQQQQRELKEQQEQAKAPVYVPPEEVNESSELYF 467
            |.....|..:..|:||              ..:....||:......:||..:  :.|.:::|:  
  Fly   894 RLYRLHPLPISDLKAIQVAAREITLHWTAPAGEYTDFELQYLSADEEAPQLL--QNVTKNTEI-- 954

  Fly   468 PDNFAPFKRARGRSRGGLAEEVEDEQPKRSFFRELAGEQGLVQEPPLRFRHVET------EVDAT 526
                                .::..:|..::...:....|.:|........|.|      .:.|:
  Fly   955 --------------------TLQGLRPYHNYTFTVVVRSGSIQGTDFADVSVSTLMRSSAPISAS 999

  Fly   527 PELVKRRPASFKQLDPYDVSLQQQEMAFESGLLRNSLTPLEEE----------------AMLASN 575
            .:.:...|.......|.||  |..|:.||.     ||.|.|:.                |.::|.
  Fly  1000 YQTLTAPPGKVDYFQPSDV--QPGEVTFEW-----SLEPAEQHGPIDYFRITCQNADDAADVSSY 1057

  Fly   576 SFPRQAKSQRVYTEGGLLLMPQDEQDTDGMQADEPEN--VKQSLLANMLGF-ARHERLDVKKPGP 637
            .||..|      |:|.:          ||:   .|.|  :.:....:.||: |..|.:...   |
  Fly  1058 EFPVNA------TQGKI----------DGL---VPGNHYIFRIQAKSALGYGAEREHIQTM---P 1100

  Fly   638 LLGP----PSLGSAELSNQLETEKAHKQKGHGNKEVLPAHIKGNDEDDAHKKKKVMKQQHS---A 695
            :|.|    ||:...|:|....|.:...::|:.:              :||.    |.:.::   |
  Fly  1101 ILAPPVPEPSVTPLEVSRTSSTIEISFRQGYFS--------------NAHG----MVRSYTIIIA 1147

  Fly   696 EDHAPHTVDTEYVHVFVKNPIDSWNDGQRIMKELEQILHMQGYFSYLTVQQHEVSFRVNSNNPER 760
            ||...:....|         :.||.|             :|.|..:|..|..|......::|..|
  Fly  1148 EDVGKNASGLE---------MPSWQD-------------VQAYTVWLPYQAIEPYNPFLTSNGSR 1190

  Fly   761 KTAGDVAR-TINENRGVKNNIQRRVGFY--VLHAGVGDVIK-------DLQDPSVSSSRIELAEQ 815
            |::.:... ||    |..|..:.:.|:.  .|.||....||       |....:|.||       
  Fly  1191 KSSLEAEHFTI----GTANCDKHQAGYCNGPLRAGTTYRIKIRAFTDEDKFTDTVYSS------- 1244

  Fly   816 GPDVTHIMAYMFAGAGAAAVIVIFVTLILIK-RHD----RKRDKLGGLQSGIAGAETCSKDYQEL 875
             |..|.....:...|..:||:::.:.|:::. :|.    |:..||..:|..:|.           
  Fly  1245 -PITTERSDTVIVAATVSAVLLVAMVLVVVYCQHRCQLIRRASKLARMQDELAA----------- 1297

  Fly   876 CRARMAGKAGGGGNSTGGAAGGGSNEPAPSGRITSLSKENEGRPPSSRSSTSSWSEEPALTNMDI 940
                                       .|.|.||      ..||...:               |.
  Fly  1298 ---------------------------LPEGYIT------PNRPVHVK---------------DF 1314

  Fly   941 STGHMVLSYMEDHLRNKGRLQREWEALCRYEAEPSAREAASQPQCAGLNRPGAPLPYDHSRVVLN 1005
            |..:.::|...|.     |...|:|.| ::.....|...|:.|.....||....|||||||..|.
  Fly  1315 SEHYRIMSADSDF-----RFSEEFEEL-KHVGRDQACSFANLPCNRPKNRFTNILPYDHSRFKLQ 1373

  Fly  1006 HLANAEGLDYVNASTITDHD-PRAPAYVAAQGPLPSTLAHFWQMIWEQGAVVIVALCRLQENGEV 1069
            .:.:.:|.||:||:.:..|: ||  .::..||||.||...||:|.||..:..||.|.|..|.|..
  Fly  1374 PVDDDDGSDYINANYMPGHNSPR--EFIVTQGPLHSTREEFWRMCWESNSRAIVMLTRCFEKGRE 1436

  Fly  1070 ACARYWP-EEGAEVYHIYEVHLVSE---HIW-CDDYLVRSFYLKNLRTSETRTVTQFHFLSWPHM 1129
            .|.:||| :..|..|...:|.|:.:   |.| ..:::|.       |..|:|.:..|||.:||..
  Fly  1437 KCDQYWPVDRVAMFYGDIKVQLIIDTHYHDWSISEFMVS-------RNCESRIMRHFHFTTWPDF 1494

  Fly  1130 GVPAQAKALLDFRRKVNKSYR---GRRSCPIVVHGSAGAGRTGVYILLDLVLERMNKGAREIDIA 1191
            |||...::|:.|.|    ::|   |....||:||.|||.||:|.:|.||.:|:.::| :..:||.
  Fly  1495 GVPEPPQSLVRFVR----AFRDVIGTDMRPIIVHCSAGVGRSGTFIALDRILQHIHK-SDYVDIF 1554

  Fly  1192 ATLEHLRDQRAGVVATRQQFEFV---LMAVAE-EVHAILKALP--ANTSGE--KRELDKDPVVGG 1248
            ..:..:|.:|..:|.|.||:..:   |:||.| :.|.:..:|.  ||...|  |..|::.|....
  Fly  1555 GIVFAMRKERVFMVQTEQQYVCIHQCLLAVLEGKEHLLADSLELHANDGYEVTKIYLERQPQTKM 1619

  Fly  1249 GS----SSTTTKEPL--------KEDKAQEAAEEEAPTSSSKAAAAAKKEKEKDKDKEEKQAKDQ 1301
            |:    :|....|.|        .||:.||..:::....:::.......:.|:|::.::....||
  Fly  1620 GTLPIRASLAMAEKLDADLMTNKDEDEDQEQQQQQQLQLATEVKPKGSNDDEEDEEDDDDDDDDQ 1684

  Fly  1302 AKVAEPRTPAKSA 1314
            ..:....|...|:
  Fly  1685 QPLNNETTATLSS 1697

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
IA-2NP_608562.4 Receptor_IA-2 708..795 CDD:288410 19/89 (21%)
PTPc 960..1220 CDD:214550 94/271 (35%)
PTPc 995..1220 CDD:238006 86/236 (36%)
Ptp4ENP_001162669.1 FN3 151..242 CDD:238020
fn3 247..328 CDD:278470
fn3 343..417 CDD:278470
fn3 443..525 CDD:278470 2/7 (29%)
FN3 548..611 CDD:238020 14/84 (17%)
FN3 620..706 CDD:238020 15/96 (16%)
fn3 708..796 CDD:278470 14/95 (15%)
fn3 824..886 CDD:278470 13/76 (17%)
fn3 902..978 CDD:278470 11/99 (11%)
fn3 1013..1092 CDD:278470 24/104 (23%)
UP_III_II 1106..>1248 CDD:297589 39/193 (20%)
PTPc 1329..1582 CDD:214550 91/267 (34%)
PTPc 1355..1582 CDD:238006 85/240 (35%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C45443506
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 1 1.000 - - otm46470
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
32.840

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