Protein Alignment IA-2 and Ptpn18

DIOPT Version :10

• Sequence 1: NP_608562.4
• Gene: IA-2 / 33277
• FlyBaseID: FBgn0031294
• Length: 1319
• Species: Drosophila melanogaster
• Sequence 2: XP_063122948.1
• Gene: Ptpn18 / 301333
• RGDID: 1311586
• Length: 507
• Species: Rattus norvegicus
• Alignment Length: 345
• Identity: 104/345 - (30%)
• Similarity: 157/345 - (45%)
• Gaps: 49/345 - (14%)

  Fly   945 MVLSYMEDHLRNKGRLQREWEALCRYEAEPSAR------------EAASQPQCAGLNRPGAPLPY 997
            :|.|::|   :.:.|..||...|.|..::..||            :|.||...:..||....:||
  Rat     7 LVRSFLE---QQEARDHREGAILAREFSDIKARSVAWKTEGVCSTKAGSQQGNSKKNRYKDVVPY 68

  Fly   998 DHSRVVLNHLANAEGLDYVNASTITDHDPRAPAYVAAQGPLPSTLAHFWQMIWEQGAVVIVALCR 1062
            |.:||:|:.|......||:||:.|...| .:.||:|.|||||.||..||:::||.|..||:..|:
  Rat    69 DETRVILSLLQEEGHGDYINANFIRGTD-GSQAYIATQGPLPHTLLDFWRLVWEFGVKVILMACQ 132

  Fly  1063 LQENGEVACARYWPEEGAEVY-HIYEVHLVSEHIWCDDYLVRSFYLKNLRT----SETRTVTQFH 1122
            ..|||...|.|||.:|...:. ..:.:.|..|.....|..:|:..:...:.    .|:|.|.|..
  Rat   133 ETENGRRKCERYWAQEREPLQAGPFCITLTKETALTADITLRTLQVTFQKVPKGQKESRPVHQLQ 197

  Fly  1123 FLSWPHMGVPAQAKALLDFRRKVNKSYRGRRSCPIVVHGSAGAGRTGVYILLDLVLERMNKGARE 1187
            ::|||..|||:.:..:|....:. :..:|....|:.||.|||.|||||...:|.|        |:
  Rat   198 YMSWPDHGVPSSSDHILTMVEEA-RCLQGLGPGPLCVHCSAGCGRTGVLCAVDYV--------RQ 253

  Fly  1188 IDIAATLE----------HLRDQRAGVVATRQQFEFVLMAVAEEVHAILK---ALPANTSGEKRE 1239
            :.:..|:.          .:|.||...|.|.:|:.|:...||:.....|:   .|..|....:..
  Rat   254 LLLTQTIPPNFSLFEVVLEMRKQRPAAVQTEEQYRFLYHTVAQLFSRTLQNNSPLYQNLKENRAP 318

  Fly  1240 LDKDPVVGGGSSSTTTKEPL 1259
            :.||      |||..|...|
  Rat   319 ICKD------SSSLRTSSAL 332

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
IA-2	NP_608562.4	Receptor_IA-2	705..795	CDD:463293
		PTP_DSP_cys	942..1225	CDD:475123	94/306 (31%)
Ptpn18	XP_063122948.1	None