Protein Alignment IA-2 and Ptprn2

DIOPT Version :9

• Sequence 1: NP_608562.4
• Gene: IA-2 / 33277
• FlyBaseID: FBgn0031294
• Length: 1319
• Species: Drosophila melanogaster
• Sequence 2: XP_038967789.1
• Gene: Ptprn2 / 29714
• RGDID: 61904
• Length: 1026
• Species: Rattus norvegicus
• Alignment Length: 1249
• Identity: 410/1249 - (32%)
• Similarity: 569/1249 - (45%)
• Gaps: 360/1249 - (28%)

  Fly   106 VPPTLP--------ARGRHLISEGARRREVRGCGAGGGGLLCCSLDALSRPAKLLQFGVLLLILL 162
            :||.||        ||||.|.....:|.|                  |..|           ||
  Rat    13 LPPPLPRALPAPASARGRQLPGRLGKRME------------------LENP-----------IL- 47

  Fly   163 LATHGDLAQAEGNV-GCQFVRTLCIPHSEVCYDDNIFGKCIPTTGVDVEDIEKTPLTEDQSRVLA 226
                .|:.|.:.:. ||.|...|| ...|.|.:|.:||:|.....:|....|.:|......|::
  Rat    48 ----SDVTQNQKDTYGCLFEDGLC-GSLETCVNDGVFGRCQKVPALDTYRYEVSPGALLHLRII- 106

  Fly   227 TMLEELQGAGLGWDHPYVQCRIQGSL-----------------------------FSLQRQQQLP 262
              |::|...|..|...|.|..|...|                             |||:.:..|.
  Rat   107 --LQKLSRTGFTWQDDYTQRVIAQELSNLPKAYLWHEEASSPARSLQQNADNEKWFSLESEVALA 169

  Fly   263 PNL--------------CANLAP-----TPPEFGD---PASALAYVRFTPPEPEAELDYYEQPAG 305
            ..|              .||..|     |.|..|:   |.:.|.||..|     :.|.|
  Rat   170 KTLRRYLPYLELLSQAPTANAHPRIDHETRPVKGEDSSPENILTYVAHT-----SALTY------ 223

  Fly   306 PAQFYPALRKKQVRESDADDMYLNRMLQDRRRLRHDPSELEHFGKMDGHGQSTQLDAPSIMDAFL 370
            |    ||.|.|          |.:.:|:...||:  |.||           |.::|:
  Rat   224 P----PATRVK----------YPDNLLRPLSRLQ--PDEL-----------SPKVDS-------- 253

  Fly   371 DTERQRIEREQQLAA-AEQDADRRAEQNRLELYQILAASEPDPQPY------QRKPAAQPNAMDQ 428
            |.::|::     :|| ....|.|...:|..|...::.:....|:|:      ||.|....::.|.
  Rat   254 DIDKQKL-----IAALGAYTAQRPPGENDPEPRYLVHSPMRAPRPFAAPALSQRWPLPPGDSKDS 313

  Fly   429 L---------EAIVEQQQQRE--------LKEQQEQAKAPVYVPPEEVNESSELYFPDNFAPFKR 476
            |         ..:.:.|||.|        |:||.:.....:...|.|.::.|
  Rat   314 LSMGDDTLLRSLLKDLQQQAEVDRLGSLKLEEQADSIAGAIQSDPVEGSQES------------- 365

  Fly   477 ARGRSRGGLAEEVEDEQPKRSFFRELAGEQGLVQEPPLRFRHVETEVDATPELVKRRPASFKQLD 541
             .||...|...|..|           |.|: ::|:      |...|||        .||::|::
  Rat   366 -HGRGAEGQLREQAD-----------APEE-MLQD------HRLPEVD--------DPAAYKEV- 402

  Fly   542 PYDVSLQQQEMAFESG-LLRNSLTPLEEEA-MLASNSFPRQAKSQRVYTEGGLLLMPQD----EQ 600
                    ..::|:.| ||::..:||..|| :|..:|.....||::          |::    |:
  Rat   403 --------SRLSFKLGDLLKDHGSPLLPEAPLLEKSSRAEMKKSEQ----------PEEVLSSEE 449

  Fly   601 DTDGMQADEPENVKQSLLANMLGFARHERLDVKKPGP------------------------LLGP 641
            :|.|::..:.....:.||         ||....:|.|                        ..||
  Rat   450 ETAGVEHVKSRTYSKDLL---------ERKPNSEPQPWRLEDQFQNRAPEVWEDEQNLKLAAQGP 505

  Fly   642 PSLGSAELSNQLETEKA-HKQKGHGNKEVLPAHIKGNDEDDAHKKKKVMKQQHSAEDHAPHTVDT 705
            ||.|.     |||.:.: .:|:|:        .:.||
  Rat   506 PSGGL-----QLEVQPSEEEQQGY--------ILTGN---------------------------- 529

  Fly   706 EYVHVFVKNPIDSWNDGQRIMKELEQILHM-QGYFSYLTVQQHEVSFRVNSNNPERKTAGDVART 769
                    ||: |...|:::|.|:..:|.: ..:|:.:.|....|.|:| |.|.:..|..||.:.
  Rat   530 --------NPL-SPEKGKQLMDEVAHLLRVPSSFFADVKVLGPAVIFKV-SANIQNMTTADVTKA 584

  Fly   770 INENRGVKNNIQRRVGFYVLHAGV--GDVIKDLQDPSVSSSRIELAEQGPDVTHIMAYMFAGAGA 832
            ..:|   |:.:::..|..:|.:|:  ...:|.|..|          |:..|.|..:...|.....
  Rat   585 AVDN---KDELEKATGLTILQSGIRPKGKLKLLPHP----------EEQEDSTKFIVLTFLSIAC 636

  Fly   833 AAVIVIFVTLILIKRHD---RKRDKLGGLQSGIAGAETCSKDYQELCRARMAGKAGGGGNSTGGA 894
            ...:::..:|....||:   :.::||.||  |...:...::.||||||.|||.:.
  Rat   637 ILAVLLASSLAYCLRHNSHYKLKEKLSGL--GADPSADATEAYQELCRQRMAVRP---------- 689

  Fly   895 AGGGSNEPAPSGRITSLSKENEGRP---PSSRSSTSSWSEEPALTNMDISTGHMVLSYMEDHLRN 956
              ...:|...:.||.|:|.:....|   ||:||||||||||||.:|||||||||:|:||||||:|
  Rat   690 --QDHSEGPHTSRINSVSSQLSDGPMPSPSARSSTSSWSEEPAQSNMDISTGHMILAYMEDHLKN 752

  Fly   957 KGRLQREWEALCRYEAEPSAREAASQPQCAGLNRPGAPLPYDHSRVVLNHLANAEGLDYVNASTI 1021
            |.||::||||||.|:|||.:...|.:.:.|..||..|.|.|||||::|....:....||:|||.|
  Rat   753 KNRLEKEWEALCAYQAEPDSSLVAQREENAPKNRSLAVLTYDHSRILLKSENSHSNSDYINASPI 817

  Fly  1022 TDHDPRAPAYVAAQGPLPSTLAHFWQMIWEQGAVVIVALCRLQENGEVACARYWPEEGAEVYHIY 1086
            .|||||.|||:|.|||||:|:|.||||:||.|..|||.|..|.|||...|..|||:||:.|||:|
  Rat   818 MDHDPRNPAYIATQGPLPATVADFWQMVWESGCAVIVMLTPLSENGVRQCHHYWPDEGSNVYHVY 882

  Fly  1087 EVHLVSEHIWCDDYLVRSFYLKNLRTSETRTVTQFHFLSWPHMGVPAQAKALLDFRRKVNKSYRG 1151
            ||:||||||||.|:||||||||||:|:|||||||||||||...|||:..::||||||||||.|||
  Rat   883 EVNLVSEHIWCQDFLVRSFYLKNLQTNETRTVTQFHFLSWYDQGVPSSTRSLLDFRRKVNKCYRG 947

  Fly  1152 RRSCPIVVHGSAGAGRTGVYILLDLVLERMNKGAREIDIAATLEHLRDQRAGVVATRQQFEFVLM 1216
             |||||:||.|.||||:|.|:|:|:||.:|.|||:|||||||||||||||.|:|.|::||||.|.
  Rat   948 -RSCPIIVHCSDGAGRSGTYVLIDMVLNKMAKGAKEIDIAATLEHLRDQRPGMVQTKEQFEFALT 1011

  Fly  1217 AVAEEVHAILKALP 1230
            ||||||:|||||||
  Rat  1012 AVAEEVNAILKALP 1025

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
IA-2	NP_608562.4	Receptor_IA-2	708..795	CDD:288410	22/89 (25%)
		PTPc	960..1220	CDD:214550	168/259 (65%)
		PTPc	995..1220	CDD:238006	152/224 (68%)
Ptprn2	XP_038967789.1	RESP18	80..148	CDD:405616	14/70 (20%)
		Receptor_IA-2	520..608	CDD:402927	26/136 (19%)
		R-PTP-N2	738..1020	CDD:350458	186/282 (66%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	329	1.000	Domainoid score	I1123
eggNOG	1	0.900	-	-		E2759_KOG0793
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	522	1.000	Inparanoid score	I1214
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D281324at33208
OrthoFinder	1	1.000	-	-		FOG0002390
OrthoInspector	1	1.000	-	-		otm46407
orthoMCL	1	0.900	-	-		OOG6_105521
Panther	1	1.100	-	-	O	PTHR46106
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X1583
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	13	12.830